ACDC

Common Name(s)

ACDC, Arterial calcification due to CD73 deficiency

Arterial calcification due to deficiency of CD73, or ACDC, is a rare, adult-onset vascular disorder. People with ACDC have calcium build-up in the large vessels (mainly below the waist) and in the joints of the hands and feet. Signs and symptoms may include progressive pain and cramping in the calves, thighs, buttocks, feet, and/or hands. The age of onset has been reported as early as the second decade of life. ACDC is caused by mutations in the NT5E gene and is inherited in an autosomal recessive manner.
 

Advocacy and Support Organizations

 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "ACDC" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "ACDC" returned 4 free, full-text research articles on human participants. First 3 results:

ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity.
 

Author(s): Nabila Bouatia-Naji, David Meyre, Stéphane Lobbens, Karin Séron, Frédéric Fumeron, Beverley Balkau, Barbara Heude, Béatrice Jouret, Philipp E Scherer, Christian Dina, Jacques Weill, Philippe Froguel

Journal: Diabetes. 2006 Feb;55(2):545-50.

 

Common single nucleotide polymorphisms (SNPs) in the ACDC adiponectin encoding gene have been associated with insulin resistance and type 2 diabetes in several populations. Here, we investigate the role of SNPs -11,377C > G, -11,391G > A, +45T > G, and +276G > T in 2,579 French Caucasians ...

Last Updated: 30 Jan 2006

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Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin.
 

Author(s): Jessica G Woo, Lawrence M Dolan, Ranjan Deka, Ritesh D Kaushal, Yayun Shen, Prodipto Pal, Stephen R Daniels, Lisa J Martin

Journal: Diabetes. 2006 Feb;55(2):523-9.

 

Adiponectin, an adipocyte protein important in insulin sensitization and cardioprotection, has a strong genetic component. We hypothesized that variants in the adiponectin gene (adipocyte collagen-domain containing [ACDC]) contribute to adiponectin levels in a biracial adolescent ...

Last Updated: 30 Jan 2006

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ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity.
 

Author(s): László B Tankó, Afshan Siddiq, Cécile Lecoeur, Philip J Larsen, Claus Christiansen, Andrew Walley, Philippe Froguel

Journal: Obes. Res.. 2005 Dec;13(12):2113-21.

 

The main purpose of this study was to investigate associations of single-nucleotide polymorphisms (SNPs) in the adipocyte C1q and collagen domain-containing (ACDC) gene and its regulator, the nuclear peroxisome proliferator-activated receptor (PPAR)-gamma gene, with body fat mass ...

Last Updated: 19 Jan 2006

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "ACDC" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)
 

Status: Recruiting

Condition Summary: Arterial Calcification Due to CD73-Deficiency (ACDC)

 

Last Updated: 12 May 2017

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Anti-Androgens and Cabazitaxel in Defining Complete Response in Prostatectomy (ACDC Trial)
 

Status: Recruiting

Condition Summary: Prostate Cancer

 

Last Updated: 1 Dec 2016

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Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.
 

Status: Recruiting

Condition Summary: Subarachnoid Hemorrhage, Aneurysmal

 

Last Updated: 29 Mar 2017

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