Acanthosis Nigricans

Common Name(s)

Acanthosis Nigricans

Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. This condition usually appears slowly and doesn't cause any symptoms other than skin changes. Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. Less commonly, the lips, palms, soles of the feet, or other areas may be affected. The exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acanthosis Nigricans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acanthosis Nigricans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acanthosis Nigricans" returned 95 free, full-text research articles on human participants. First 3 results:

Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma.
 

Author(s): Qian Yu, Xiu-Li Li, Guo Ji, Yao Wang, Yu Gong, Hui Xu, Yu-Ling Shi

Journal:

 

Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before.

Last Updated: 31 Dec 1969

Go To URL
Laparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans.
 

Author(s): Yi Zhang, Cuiling Zhu, Xin Wen, Xingchun Wang, Liang Li, Sharvan Rampersad, Liesheng Lu, Donglei Zhou, Chunhua Qian, Ran Cui, Manna Zhang, Peng Yang, Shen Qu, Le Bu

Journal:

 

Acanthosis nigricans (AN) has a close relationship with obesity. It is believed that obesity and AN have the common pathophysiological basis such as hyperinsulinism. This study is aimed to observe the effect of laparoscopic sleeve gastrectomy (LSG) on body composition and insulin ...

Last Updated: 31 Dec 1969

Go To URL
A Mutation in INSR in a Child Presenting with Severe Acanthosis Nigricans.
 

Author(s): Hale Tuhan, Serdar Ceylaner, Özlem Nalbantoğlu, Sezer Acar, Ayhan Abacı, Ece Böber, Korcan Demir

Journal: J Clin Res Pediatr Endocrinol. 2017 Dec;9(4):371-374.

 

Rabson-Mendenhall syndrome (RMS) is an autosomal recessive disorder due to mutations in the insulin receptor gene (INSR) which is mapped to 19p13.2. RMS is characterized by acanthosis nigricans, generalized lanugo, tooth and nail dysplasia, high nasal bridge, and growth retardation. ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acanthosis Nigricans" returned 8 free, full-text review articles on human participants. First 3 results:

Association of acanthosis nigricans and skin tags with insulin resistance.
 

Author(s): Mariana Tremel Barbato, Paulo Ricardo Criado, Ana Kris da Silva, Evelyne Averbeck, Marina Bensen Guerine, Naiana Bittencourt de Sá

Journal: An Bras Dermatol. ;87(1):97-104.

 

Insulin resistance is a metabolic disorder in which target cells fail to respond to normal levels of circulating insulin. Insulin resistance has been associated with presence of acanthosis nigricans and acrochordons. It is known that early diagnosis and early initial treatment are ...

Last Updated: 31 Dec 1969

Go To URL
Acanthosis nigricans in the setting of niacin therapy.
 

Author(s): Rachael Hartman, Taylor Defelice, Julia Tzu, Shane Meehan, Miguel Sanchez

Journal:

 

We report the case of a 63-year-old obese man with a rapid-onset of widespread acanthosis nigricans (AN) in the setting of having recently initiated treatment with niacin for dyslipidemia. Although obesity and insulin-resistance are risk factors for AN, AN associated with endocrine ...

Last Updated: 31 Dec 1969

Go To URL
Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature.
 

Author(s): Mirella Krawczyk, Joanna Mykała-Cieśla, Aleksandra Kołodziej-Jaskuła

Journal: Pol. Arch. Med. Wewn.. 2009 Mar;119(3):180-3.

 

Acanthosis nigricans (AN) is a skin disorder characterized by focal or diffuse hyperkeratosis symmetric hyperpigmentation of the skin and oral cavity mucosa. Various neoplasms, especially gastrointestinal adenocarcinomas are associated with acanthosis nigricans (AN malignant). Chemotherapy ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.