Acanthosis Nigricans

Common Name(s)

Acanthosis Nigricans

Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. This condition usually appears slowly and doesn't cause any symptoms other than skin changes. Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. Less commonly, the lips, palms, soles of the feet, or other areas may be affected. The exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acanthosis Nigricans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acanthosis Nigricans" returned 91 free, full-text research articles on human participants. First 3 results:

A study of the association of acanthosis nigricans with subclinical atherosclerosis.
 

Author(s): Elizabeth Guevara-Gutiérrez, Alberto Tlacuilo-Parra, Pedro Gutiérrez-Fajardo, Tania Sánchez-Tenorio, Fernando Barba-Gómez, Alejandra Miranda-Díaz

Journal: Indian J Dermatol Venereol Leprol. ;83(2):190-194.

 

Hyperinsulinism is related to the presence of acanthosis nigricans and atherosclerosis; however, we were unable to find any study on the prevalence of atherosclerosis in acanthosis nigricans.

Last Updated: 6 Feb 2017

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Prevalence of obesity and acanthosis nigricans among young children in the children's healthy living program in the United States Affiliated Pacific.
 

Author(s): Rachel Novotny, Fenfang Li, Marie Kainoa Fialkowski, Andrea Bersamin, Aifili Tufa, Jonathan Deenik, Patricia Coleman, Rachael Leon Guerrero, Lynne R Wilkens,

Journal: Medicine (Baltimore). 2016 Sep;95(37):e4711.

 

Estimate prevalence of obesity and acanthosis nigricans (AN) among children in United States Affiliated Pacific (USAP) jurisdictions.Cross-sectional measurement of weight, height, and AN in 5775, 2 to 8 years old in 51 communities-Hawai'i, Alaska, Commonwealth of the Northern Mariana ...

Last Updated: 16 Sep 2016

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Unilateral nevoid acanthosis nigricans treated with CO2 laser.
 

Author(s): Manuel António Campos, Paulo Varela, Armando Baptista, Eduarda Osório Ferreira

Journal:

 

Last Updated: 26 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acanthosis Nigricans" returned 6 free, full-text review articles on human participants. First 3 results:

Association of acanthosis nigricans and skin tags with insulin resistance.
 

Author(s): Mariana Tremel Barbato, Paulo Ricardo Criado, Ana Kris da Silva, Evelyne Averbeck, Marina Bensen Guerine, Naiana Bittencourt de Sá

Journal: An Bras Dermatol. ;87(1):97-104.

 

Insulin resistance is a metabolic disorder in which target cells fail to respond to normal levels of circulating insulin. Insulin resistance has been associated with presence of acanthosis nigricans and acrochordons. It is known that early diagnosis and early initial treatment are ...

Last Updated: 6 Apr 2012

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Acanthosis nigricans in the setting of niacin therapy.
 

Author(s): Rachael Hartman, Taylor Defelice, Julia Tzu, Shane Meehan, Miguel Sanchez

Journal:

 

We report the case of a 63-year-old obese man with a rapid-onset of widespread acanthosis nigricans (AN) in the setting of having recently initiated treatment with niacin for dyslipidemia. Although obesity and insulin-resistance are risk factors for AN, AN associated with endocrine ...

Last Updated: 27 Oct 2011

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Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature.
 

Author(s): Mirella Krawczyk, Joanna Mykała-Cieśla, Aleksandra Kołodziej-Jaskuła

Journal: Pol. Arch. Med. Wewn.. 2009 Mar;119(3):180-3.

 

Acanthosis nigricans (AN) is a skin disorder characterized by focal or diffuse hyperkeratosis symmetric hyperpigmentation of the skin and oral cavity mucosa. Various neoplasms, especially gastrointestinal adenocarcinomas are associated with acanthosis nigricans (AN malignant). Chemotherapy ...

Last Updated: 11 Jun 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.