Achalasia

Common Name(s)

Achalasia

Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach.  It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax.  Achalasia is caused by damage to the nerves of the esophagus. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Achalasia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Achalasia" returned 414 free, full-text research articles on human participants. First 3 results:

Obstructive bronchitis and recurrent pneumonia in esophageal achalasia in a child: A CARE compliant case report.
 

Author(s): Alexandr Evgen'evich Mashkov, Dmitrii Anatolèvich Pykchteev, Alexandr Viktorovic Sigachev, Andrei Viktorovich Bobylev, Johannes Michael Mayr

Journal: Medicine (Baltimore). 2018 Jun;97(23):e11016.

 

Esophageal achalasia is characterized by impaired relaxation of the cardia and dilation of the intrathoracic part of the esophagus. We describe the late presentation of achalasia in an 11-year old girl.

Last Updated: 31 Dec 1969

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Activated Eosinophils are Present in Esophageal Muscle in Patients with Achalasia of the Esophagus.
 

Author(s): Hong Jin, Bin Wang, Li-Li Zhang, Wei Zhao

Journal:

 

BACKGROUND The aim of this study was to undertake a histological evaluation of the presence of eosinophils in esophageal muscle in patients with achalasia before treatment with peroral endoscopic myotomy (POEM), with clinical follow-up at one year. MATERIAL AND METHODS Before treatment, ...

Last Updated: 31 Dec 1969

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New endoscopic classification of esophageal mucosa in achalasia: A predictor for submucosal fibrosis.
 

Author(s): Xiuxue Feng, Enqiang Linghu, Ningli Chai, Hui Ding

Journal: Saudi J Gastroenterol. ;24(2):122-128.

 

In this study, we aim to investigate the predicting ability of one new endoscopic classification of esophageal mucosa in achalasia (EMIA) for submucosal fibrosis (SMF) affecting the success of peroral endoscopic myotomy (POEM).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Achalasia" returned 60 free, full-text review articles on human participants. First 3 results:

Peroral Endoscopic Myotomy Versus Heller Myotomy for Achalasia: Pros and Cons.
 

Author(s): Cristian Tefas, Rami Ababneh, Marcel Tanţău

Journal: Chirurgia (Bucur). ;113(2):185-191.

 

Achalasia is an esophageal motor disorder that has multiple endoscopic and surgical methods of treatment. However, there is no consensus on optimal therapy in patients suffering from this disorder. This review discusses two therapies with similar but technically different concepts, ...

Last Updated: 31 Dec 1969

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High Resolution Manometry - A Mandatory Examination in the Pre and Postoperative Assessment of Patients with Achalasia.
 

Author(s): Anca Dimitriu, Cristian Gheorghe

Journal: Chirurgia (Bucur). ;113(1):61-69.

 

High resolution manometry (HRM) is currently the gold standard for the diagnosis of achalasia and other functional esophageal disorders. All patients accusing dysphagia should be endoscopically evaluated prior to manometric investigations in order to rule out pseudoachalasia. The ...

Last Updated: 31 Dec 1969

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Clinical Practice Update: The Use of Per-Oral Endoscopic Myotomy in Achalasia: Expert Review and Best Practice Advice From the AGA Institute.
 

Author(s): Peter J Kahrilas, David Katzka, Joel E Richter

Journal: Gastroenterology. 2017 11;153(5):1205-1211.

 

The purpose of this review is to describe a place for per-oral endoscopic myotomy (POEM) among the currently available robust treatments for achalasia. The recommendations outlined in this review are based on expert opinion and on relevant publications from PubMed and EMbase. The ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia
 

Status: Recruiting

Condition Summary: Achalasia Cardia

 

Last Updated: 20 Feb 2018

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Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 28 Dec 2017

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Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study
 

Status: Recruiting

Condition Summary: Achalasia

 

Last Updated: 25 Jan 2018

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