Acinic cell carcinoma

Common Name(s)

Acinic cell carcinoma

Acinic cell carcinoma (ACC) is a rare type of cancer that most commonly develops in areas of the body where saliva is produced (salivary glands). The largest of these saliva-producing sites, and also the most common location where ACCs develop, is the parotid gland, which can be found on either side of the face just a little in front of and below the ears. Less commonly, ACCs grow inside the mouth. Very rarely, some types of ACCs can also develop in areas such as the pancreas and lungs. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread (metastasize) to other parts of the body.

ACCs most commonly occur in adults between the ages of 40 and 60, though they can appear in all age groups. Factors that may increase the risk of developing ACCs include smoking, exposure to radiation, exposure to viral infections, and workplace exposure to rubber or asbestos. The most common symptoms of ACCs include weakness of the muscles of the face or numbness of the face. There may also be swelling or the presence of a lump near the neck, mouth, or cheek areas, which may or may not be painful. Depending on the size of the cancer, one may experience difficulty swallowing as well. Diagnoses are made usually with a combination of a physical exam, imaging studies, and other laboratory studies.

Treatment for ACCs depend on many factors such as how large the tumor is, and if it has spread to other areas of the body. If you or a family member has been diagnosed with ACC, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acinic cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acinic cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acinic cell carcinoma" returned 30 free, full-text research articles on human participants. First 3 results:

Acinic cell carcinoma of minor salivary glands - case report.
 

Author(s): Camelia Liana Buhaş, Elena Roşca, Gabriela MuŢiu, Alina Cristiana Venter, Bogdan Adrian Buhaş, Răzvan CouŢi, Camelia Florentina Ciobanu, Dragoş Mircea Roşca

Journal: Rom J Morphol Embryol. 2017 ;58(3):1003-1007.

 

Salivary gland tumors have a high incidence (90%) within the parotid gland. The acinic cell carcinoma (ACC) represents only 1-3% of the salivary gland tumors, most frequently affecting the parotid. The minor salivary glands rarely develop ACC and when the ACC is localized in these ...

Last Updated: 31 Dec 1969

Go To URL
Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma.
 

Author(s): Nicholas Barasch, Xue Gong, Kevin A Kwei, Sushama Varma, Jewison Biscocho, Kunbin Qu, Nan Xiao, Joseph S Lipsick, Robert J Pelham, Robert B West, Jonathan R Pollack

Journal:

 

Pathogenic gene fusions have been identified in several histologic types of salivary gland neoplasia, but not previously in acinic cell carcinoma (AcCC). To discover novel gene fusions, we performed whole-transcriptome sequencing surveys of three AcCC archival cases. In one specimen ...

Last Updated: 31 Dec 1969

Go To URL
Ultrastructural Characterization of Mammary Analogue Secretory Carcinoma of the Salivary Glands: A Distinct Entity from Acinic Cell Carcinoma?
 

Author(s): Julie Guilmette, Gunnlaugur P Nielsen, William C Faquin, Martin Selig, Vânia Nosé, Anthony W S Chi, Peter M Sadow

Journal: Head Neck Pathol. 2017 Dec;11(4):419-426.

 

Mammary analogue secretory carcinoma (MASC) of the salivary glands is a recently described neoplasm of the salivary glands with a characteristic morphology complemented by a specific cytogenetic translocation and gene rearrangements. Although immunophenotypic and cytogenetic differences ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acinic cell carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Pure acinic cell carcinoma of the breast: A case report and literature review.
 

Author(s): Hongmei Li, Fuzhi Wang, Pingrong Shen, Feng Zhou

Journal: Medicine (Baltimore). 2017 Nov;96(47):e8866.

 

Acinic cell carcinoma (AcCC) of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation.

Last Updated: 31 Dec 1969

Go To URL
Acinic cell carcinoma of the breast: review of the literature.
 

Author(s): G Limite, R Di Micco, E Esposito, V Sollazzo, M Cervotti, G Pettinato, V Varone, G Benassai, B Amato, V Pilone, G Luglio, A Vitiello, A Hasani, F Liccardo, P Forestieri

Journal: Int J Surg. 2014 ;12 Suppl 1():S35-9.

 

The breast and salivary gland tissue share embryologic and thus pathological similarities. Acinic cell carcinoma (ACC) is a typical tumor in salivary glands, but rarely arises in breast too. We reviewed 38 cases of mammary ACC reported in literature and our case, the first ACC born ...

Last Updated: 31 Dec 1969

Go To URL
Acinic cell carcinoma of the salivary glands: a literature review.
 

Author(s): Nabil Al-Zaher, Amani Obeid, Suhail Al-Salam, Bassam Sulaiman Al-Kayyali

Journal: Hematol Oncol Stem Cell Ther. 2009 ;2(1):259-64.

 

Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men. ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Acelarin First Line Randomised Pancreatic Study
 

Status: Recruiting

Condition Summary: Pancreatic Acinar Carcinoma; Pancreatic Neoplasms

 

Last Updated: 25 Jul 2018

Go to URL
Stereotactic Radiosurgery and Metformin in Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage I-III Pancreatic Cancer

 

Last Updated: 23 Feb 2018

Go to URL
Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Stage I Pancreatic Cancer; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer

 

Last Updated: 12 Jan 2018

Go to URL