Acquired Von Willebrand syndrome

Common Name(s)

Acquired Von Willebrand syndrome

Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation. It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs. About 300 cases of this condition have been reported in the medical literature thus far. Treatment depends on the underlying cause of the condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired Von Willebrand syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acquired Von Willebrand syndrome" returned 39 free, full-text research articles on human participants. First 3 results:

Splenic Marginal Zone Lymphoma with Acquired von Willebrand Syndrome Diagnosed via Splenic Bleeding.
 

Author(s): Yukiko Komeno, Naoki Shibuya, Hideki Uryu, Haruki Yamada, Takeo Toda, Masayuki Shibasaki, Shinji Kunishima, Kuniko Iihara, Tomiko Ryu

Journal: Intern. Med.. 2017 ;56(5):557-562.

 

An 85-year-old woman underwent emergent splenectomy due to left abdominal pain and active bleeding in a massively enlarged spleen. The histological diagnosis was splenic marginal zone lymphoma (SMZL). A prolonged activated partial thromboplastin time (APTT) was noted, and additional ...

Last Updated: 2 Mar 2017

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Acquired von Willebrand syndrome in children with aortic and pulmonary stenosis.
 

Author(s): Fatih Köksal Binnetoğlu, Kadir Babaoğlu, Şayegan Güven Filiz, Emine Zengin, Gürkan Altun, Suar Çakı Kılıç, Nazan Sarper

Journal: Cardiovasc J Afr. ;27(4):222-227.

 

This prospective study was planned to investigate the frequency and relationship of acquired von Willebrand syndrome (AVWS) with aortic and pulmonary stenosis in patients.

Last Updated: 14 Nov 2016

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Acquired von Willebrand Syndrome During the Course of Myelofibrosis: Analysis of 32 Cases.
 

Author(s): Andrzej Mital, Witold Prejzner, Andrzej Hellmann

Journal: Adv Clin Exp Med. ;24(6):1001-6.

 

Identification of patients with myelofibrosis being at increased risk of acquired von Willebrand syndrome (avWS) would likely facilitate individualization of treatment and improve its outcomes.

Last Updated: 16 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acquired Von Willebrand syndrome" returned 6 free, full-text review articles on human participants. First 3 results:

Acquired von Willebrand Syndrome.
 

Author(s): Andrzej Mital

Journal: Adv Clin Exp Med. ;25(6):1337-1344.

 

Acquired von Willebrand syndrome is a rare hemorrhagic diathesis, with clinical symptoms similar to those associated with the inherited form von Willebrand disease. This syndrome is characterized by a lack of previous bleeding symptoms, negative familial history, and occurrence in ...

Last Updated: 28 Dec 2016

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Treatment of acquired von Willebrand syndrome in childhood.
 

Author(s): Michael U Callaghan, Trisha E Wong, Augusto B Federici

Journal: Blood. 2013 Sep;122(12):2019-22.

 

A 3-1/2-year-old male with no personal or family history of bleeding disorders presented with abdominal distension, epistaxis, and anemia (hemoglobin 8.2 g/dL). A magnetic resonance imaging scan of the abdomen demonstrated a mass arising from the left kidney. Preoperative laboratory ...

Last Updated: 20 Sep 2013

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How I treat the acquired von Willebrand syndrome.
 

Author(s): Andreas Tiede, Jacob H Rand, Ulrich Budde, Arnold Ganser, Augusto B Federici

Journal: Blood. 2011 Jun;117(25):6777-85.

 

The acquired von Willebrand syndrome (AVWS) is a bleeding disorder that is frequently unrecognized or is misdiagnosed as von Willebrand disease. AVWS is characterized by structural or functional defects of von Willebrand factor (VWF) that are secondary to autoimmune, lymphoproliferative ...

Last Updated: 24 Jun 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Frequency of Hemorrhages Associated With the Functional Anomalies of Willebrand Factor in Emergency Patients
 

Status: Not yet recruiting

Condition Summary: Von Willebrand Diseases

 

Last Updated: 6 Jun 2017

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