Acquired pure red cell aplasia

Common Name(s)

Acquired pure red cell aplasia

Acquired pure red cell aplasia (acquired PRCA) is a rare disorder of the bone marrow that affects red blood cells (erythrocytes). Erythrocytes are responsible for delivering oxygen to different parts of the body through the circulatory system. Acquired PRCA is most common in adults and can be caused by autoimmune diseases such as diabetes, certain cancers, viral infections, and pregnancy complications. In rare cases, a mismatched bone marrow transplant can cause PRCA.

Individuals with this condition will have very few red blood cells (anemia) which leads to the symptoms that are seen in this disorder. Symptoms of PRCA include fatigue, lethargy, and pale skin. The severity of symptoms depends on the severity of the disease, and some patients may show no symptoms at all. Erythropoietin is a hormone that helps produce red blood cells. Individuals with PRCA may have abnormally high levels of erythropoietin.

This condition is diagnosed based on a medical history and blood testing. Treatment for PRCA will depend on the underlying cause. The symptoms of PCRA will usually resolve once the underlying condition is properly treated. Talk to your doctor about the most current treatment options for PRCA.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired pure red cell aplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired pure red cell aplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acquired pure red cell aplasia" returned 21 free, full-text research articles on human participants. First 3 results:

Low-dose subcutaneous alemtuzumab is a safe and effective treatment for chronic acquired pure red cell aplasia.
 

Author(s): Jason K W Chow, T K Chan

Journal: Hong Kong Med J. 2013 Dec;19(6):549-52.

 

Three patients with pure red cell aplasia, with or without co-existing large granular lymphocytic leukaemia, who remained transfusion-dependent despite treatment with established first-line therapy, were treated with low-dose subcutaneous alemtuzumab 15 mg twice to thrice per week, ...

Last Updated: 31 Dec 1969

Go To URL
Successful treatment of acquired pure red cell aplasia with oral corticosteroids in a patient with B-cell CLL.
 

Author(s): Pramila Dharmshaktu, Naresh Gupta, Dinesh Kumar Dhanwal

Journal:

 

We present the case of a 57-year-old male patient diagnosed with chronic lymphoid leukaemia (CLL) B-cell type along with moderate anaemia. On follow-up investigations the aetiology of anaemia turned out to be pure red cell aplasia (PRCA) on trephine bone biopsy with an elevated serum ...

Last Updated: 31 Dec 1969

Go To URL
Acquired pure red cell aplasia due to anti-erythropoietin antibodies in a patient with end stage chronic kidney disease.
 

Author(s): H M S Senanayake, K Thirumavalavan, M N Gunasekara, V Ratnamalala

Journal: Ceylon Med J. 2013 Jun;58(2):86-8.

 

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acquired pure red cell aplasia" returned 1 free, full-text review articles on human participants. First 3 results:

Acquired pure red cell aplasia: updated review of treatment.
 

Author(s): Kenichi Sawada, Naohito Fujishima, Makoto Hirokawa

Journal: Br. J. Haematol.. 2008 Aug;142(4):505-14.

 

Pure red cell aplasia (PRCA) is a syndrome characterized by a severe normocytic anaemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow. Primary PRCA, or secondary PRCA which has not responded to treatment of the underlying disease, is treated ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation
 

Status: Recruiting

Condition Summary: Bone Marrow Failure Syndrome; Severe Aplastic Anemia; Severe Congenital Neutropenia; Amegakaryocytic Thrombocytopenia; Diamond-Blackfan Anemia; Schwachman Diamond Syndrome; Primary Immunodeficiency Syndromes; Acquired Immunodeficiency Syndromes; Histiocytic Syndrome; Familial Hemophagocytic Lymphocytosis; Lymphohistiocytosis; Macrophage Activation Syndrome; Langerhans Cell Histiocytosis (LCH); Hemoglobinopathies; Sickle Cell Disease; Sickle Cell-beta-thalassemia

 

Last Updated: 13 Jul 2017

Go to URL