Acrodermatitis Enteropathica

Common Name(s)

Acrodermatitis Enteropathica

Acrodermatitis enteropathica (AE) is a disorder of zinc metabolism that can either be inherited or acquired. Both forms lead to the inability to absorb zinc from the intestine. The lack of zinc can cause skin inflammation with a rash (pustular dermatitis) around the mouth and/or anus; diarrhea; and abnormal nails (nail dystrophy). Irritability and emotional disturbances can also occur. The inherited form is caused by mutations in the SLC39A4 gene and inherited in an autosomal recessive pattern. The acquired form can result from diets lacking the appropriate amount of zinc. Supplemental zinc usually eliminates the symptoms of acrodermatitis enteropathica.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acrodermatitis Enteropathica" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acrodermatitis Enteropathica" returned 48 free, full-text research articles on human participants. First 3 results:

Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report.
 

Author(s): Erina Lie, Sarah Sung, Steven Hoseong Yang

Journal:

 

Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, ...

Last Updated: 31 Dec 1969

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An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4, Regulates Human Epidermal Homeostasis.
 

Author(s): Bum-Ho Bin, Jinhyuk Bhin, Nan-Hyung Kim, Su-Hyon Lee, Haeng-Sun Jung, Juyeon Seo, Dae-Kyum Kim, Daehee Hwang, Toshiyuki Fukada, Ai-Young Lee, Tae Ryong Lee, Eun-Gyung Cho

Journal: J. Invest. Dermatol.. 2017 04;137(4):874-883.

 

Acrodermatitis enteropathica is an autosomal recessive disorder characterized by scaly eczematous dermatosis accompanied by alopecia and diarrhea. Various mutations in the SLC39A4 gene (ZIP4), which encodes a zinc transporter, are responsible for this disorder. However, the molecular ...

Last Updated: 31 Dec 1969

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Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica.
 

Author(s): Benjamin Ross, Manish Kumar, Hema Srinivasan, Alka V Ekbote

Journal: Indian Pediatr. 2016 Aug;53(8):738-40.

 

Special diet with restricted branched-chain-amino-acids used for treating maple syrup urine disease can lead to specific amino acid deficiencies.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acrodermatitis Enteropathica" returned 2 free, full-text review articles on human participants. First 3 results:

[Acrodermatitis enteropathica: report of one case].
 

Author(s): Roberto Valdés, Michelle Mauret, Álex Castro

Journal: Rev Med Chil. 2013 Nov;141(11):1480-3.

 

Acrodermatitis enteropathica is an uncommon disease caused by hereditary or acquired zinc deficiency. It is characterized by a triad of alopecia, diarrhea and acral and periorificial dermatitis. It is treated with Zinc supplementation. We report a 31-year-old indigent and drug addict ...

Last Updated: 31 Dec 1969

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Regulation and function of Zip4, the acrodermatitis enteropathica gene.
 

Author(s): Glen K Andrews

Journal: Biochem. Soc. Trans.. 2008 Dec;36(Pt 6):1242-6.

 

The SLC39A (solute carrier 39A) [ZIP (Zrt-Irt-like protein)] family consists of 14 members which are thought to control zinc uptake into the cytoplasm. Among these, ZIP4 is known to be particularly important for zinc homoeostasis. Mutations in this gene cause acrodermatitis enteropathica, ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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