Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 598 free, full-text research articles on human participants. First 3 results:

The association between biochemical control and cardiovascular risk factors in acromegaly.
 

Author(s): John D Carmichael, Michael S Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P Neary, Vivien Bonert

Journal:

 

The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors.

Last Updated: 10 Mar 2017

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Adiponectin and Cardiac Hypertrophy in Acromegaly.
 

Author(s): Sabriye Gurbulak, Fulya Akin, Emrah Yerlikaya, Guzin F Yaylali, Senay Topsakal, Halil Tanriverdi, Beyza Akdag, Bunyamin Kaptanoglu

Journal: Adv Clin Exp Med. ;25(3):449-55.

 

Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.

Last Updated: 16 Sep 2016

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The value of an acute octreotide suppression test in predicting short-term efficacy of somatostatin analogues in acromegaly.
 

Author(s): Meng Wang, Ming Shen, Wenqiang He, Yeping Yang, Wenjuan Liu, Yun Lu, Zengyi Ma, Zhao Ye, Yichao Zhang, Xiaolong Zhao, Bin Lu, Ji Hu, Yun Huang, Xuefei Shou, Yongfei Wang, Hongying Ye, Yiming Li, Shiqi Li, Yao Zhao, Zhaoyun Zhang

Journal: Endocr. J.. 2016 Sep;63(9):819-834.

 

Predicting the efficacy of long-acting somatostatin analogues (SSA) remains a challenge. We aim to quantitatively evaluate the predictive value of the octreotide suppression test (OST) in short-term efficacy of SSA in active acromegaly. Sixty-seven newly diagnosed acromegaly patients ...

Last Updated: 19 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 73 free, full-text review articles on human participants. First 3 results:

Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature.
 

Author(s): Sebastian Krug, Michael Boch, Peter Rexin, Andreas Pfestroff, Thomas Gress, Patrick Michl, Anja Rinke

Journal:

 

Pulmonary neuroendocrine tumors (NET) form a heterogeneous group of rare diseases. In these tumors, paraneoplastic syndromes have been described to drive the course of the disease, among them acromegaly induced by paraneoplastic secretion of growth hormone-releasing hormone (GHRH).

Last Updated: 28 Jun 2016

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Challenges in the diagnosis and management of acromegaly: a focus on comorbidities.
 

Author(s): Alin Abreu, Alejandro Pinzón Tovar, Rafael Castellanos, Alex Valenzuela, Claudia Milena Gómez Giraldo, Alejandro Castellanos Pinedo, Doly Pantoja Guerrero, Carlos Alfonso Builes Barrera, Humberto Ignacio Franco, Antônio Ribeiro-Oliveira, Lucio Vilar, Raquel S Jallad, Felipe Gaia Duarte, Mônica Gadelha, Cesar Luiz Boguszewski, Julio Abucham, Luciana A Naves, Nina Rosa C Musolino, Maria Estela Justamante de Faria, Ciliana Rossato, Marcello D Bronstein

Journal: Pituitary. 2016 Aug;19(4):448-57.

 

Acromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to ...

Last Updated: 7 Jul 2016

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Implementing a screening program for acromegaly in Latin America: necessity versus feasibility.
 

Author(s): Karina Danilowicz, Patricia Fainstein Day, Marcos P Manavela, Carlos Javier Herrera, María Laura Deheza, Gabriel Isaac, Ariel Juri, Debora Katz, Oscar D Bruno

Journal: Pituitary. 2016 Aug;19(4):370-4.

 

Acromegaly is a rare disease with a large burden due its associated comorbidities and the life-long management required. Since the occurrence and severity of associated complications are related to length of exposure to the excess growth hormone seen in acromegaly, early diagnosis ...

Last Updated: 7 Jul 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Patterns and Treatment Outcomes for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 2 Feb 2017

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A Prospective Study of Outcome After Therapy for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 2 Feb 2017

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Last Updated: 21 Mar 2017

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