Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 592 free, full-text research articles on human participants. First 3 results:

Adiponectin and Cardiac Hypertrophy in Acromegaly.
 

Author(s): Sabriye Gurbulak, Fulya Akin, Emrah Yerlikaya, Guzin F Yaylali, Senay Topsakal, Halil Tanriverdi, Beyza Akdag, Bunyamin Kaptanoglu

Journal: Adv Clin Exp Med. ;25(3):449-55.

 

Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.

Last Updated: 16 Sep 2016

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Combination of Klinefelter Syndrome and Acromegaly: A Rare Case Report.
 

Author(s): Hongjuan Fang, Jian Xu, Huanwen Wu, Hong Fan, Liyong Zhong

Journal: Medicine (Baltimore). 2016 Apr;95(17):e3444.

 

Klinefelter syndrome (KS) is the most common chromosomal aneuploidy in male population, which demonstrates an unusual association with acromegaly. We herein present a rare case involving the confirmation of KS 2 years after surgical treatment for acromegaly.A 27-year-old man presented ...

Last Updated: 29 Apr 2016

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Switching patients with acromegaly from octreotide to pasireotide improves biochemical control: crossover extension to a randomized, double-blind, Phase III study.
 

Author(s): Marcello D Bronstein, Maria Fleseriu, Sebastian Neggers, Annamaria Colao, Michael Sheppard, Feng Gu, Chiung-Chyi Shen, Mônica Gadelha, Andrew J Farrall, Karina Hermosillo Reséndiz, Matthieu Ruffin, YinMiao Chen, Pamela Freda,

Journal:

 

Many patients with acromegaly do not achieve biochemical control with first-generation somatostatin analogues. A large, multicenter, randomized, Phase III core study demonstrated that pasireotide LAR had significantly superior efficacy over octreotide LAR. This analysis explores the ...

Last Updated: 4 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 70 free, full-text review articles on human participants. First 3 results:

Acromegaly in a patient with a pulmonary neuroendocrine tumor: case report and review of current literature.
 

Author(s): Sebastian Krug, Michael Boch, Peter Rexin, Andreas Pfestroff, Thomas Gress, Patrick Michl, Anja Rinke

Journal:

 

Pulmonary neuroendocrine tumors (NET) form a heterogeneous group of rare diseases. In these tumors, paraneoplastic syndromes have been described to drive the course of the disease, among them acromegaly induced by paraneoplastic secretion of growth hormone-releasing hormone (GHRH).

Last Updated: 28 Jun 2016

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MANAGEMENT OF ENDOCRINE DISEASE: Acromegaly and cancer: an old debate revisited.
 

Author(s): Cesar Luiz Boguszewski, John Ayuk

Journal: Eur. J. Endocrinol.. 2016 Oct;175(4):R147-56.

 

Based on experimental and animal models, epidemiological data from non-acromegaly populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a potential association between acromegaly and cancer has long been hypothesized, in particular colorectal cancer, ...

Last Updated: 15 Aug 2016

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Pasireotide: a novel treatment for patients with acromegaly.
 

Author(s): Daniel Cuevas-Ramos, Maria Fleseriu

Journal:

 

Morbidity and mortality rates in patients with active acromegaly are higher than the general population. Adequate biochemical control restores mortality to normal rates. Now, medical therapy has an increasingly important role in the treatment of patients with acromegaly. Somatostatin ...

Last Updated: 26 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Patterns and Treatment Outcomes for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 2 Feb 2017

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A Prospective Study of Outcome After Therapy for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 2 Feb 2017

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Last Updated: 14 Jan 2017

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