Acute Hemorrhagic Leukoencephalitis

Common Name(s)

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis (AHL) is a very rare form of acute disseminated encephalomyelitis that usually results in death. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting, seizures, and coma. AHL has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. Although the exact cause is unclear, AHL usually follows a viral infection, or less often, vaccination for measles, mumps, or rubella. Some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to AHL.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Hemorrhagic Leukoencephalitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Hemorrhagic Leukoencephalitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Hemorrhagic Leukoencephalitis" returned 7 free, full-text research articles on human participants. First 3 results:

Acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome) in a patient with relapse-remitting multiple sclerosis.
 

Author(s): Özlem Yildiz, Refik Pul, Peter Raab, Christian Hartmann, Thomas Skripuletz, Martin Stangel

Journal:

 

Acute hemorrhagic leukoencephalitis is a fulminant demyelinating disease and commonly considered as a rare and severe variant of acute disseminated encephalomyelitis. Here, we report the clinical, magnetic resonance imaging, and brain biopsy findings of a 35-year-old female with relapsing-remitting ...

Last Updated: 17 Sep 2015

Go To URL
First case report of acute hemorrhagic leukoencephalitis following Plasmodium vivax infection.
 

Author(s): V Venugopal, M Haider

Journal: Indian J Med Microbiol. ;31(1):79-81.

 

Acute hemorrhagic leukoencephalitis (AHLE, Hurst's disease) is a rare hyperacute variant of acute disseminated encephalomyelitis (ADEM) characterized by severe, rapidly progressive clinical illness and hemorrhagic necrosis of white matter. Like ADEM, it is often preceded by viral ...

Last Updated: 19 Mar 2013

Go To URL
Serial MR imaging findings of acute hemorrhagic leukoencephalitis: a case report.
 

Author(s): Ho Yun Lee, Kee-Hyun Chang, Ji Hoon Kim, Dong Gyu Na, Bae Ju Kwon, Kwang-Woo Lee, Sung Hye Park

Journal: AJNR Am J Neuroradiol. 2005 Sep;26(8):1996-9.

 

We report a patient with acute hemorrhagic leukoencephalitis with a focus on serial MR imaging findings. Initial MR imaging of a 42-year-old woman revealed a 2.5-cm focal nonhemorrhagic lesion in the left thalamus and internal capsule. Twenty-four days later, fever and altered consciousness ...

Last Updated: 12 Sep 2005

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Hemorrhagic Leukoencephalitis" returned 1 free, full-text review articles on human participants. First 3 results:

Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis.
 

Author(s): Lori Broderick, Chhavi Gandhi, James L Mueller, Christopher D Putnam, Katayoon Shayan, Patricia C Giclas, Karin S Peterson, Seema S Aceves, Robert M Sheets, Bradley M Peterson, Robert O Newbury, Hal M Hoffman, John F Bastian

Journal: J. Clin. Immunol.. 2013 Jan;33(1):162-71.

 

Acute Hemorrhagic Leukoencephalitis (AHLE) is a rare demyelinating disorder of acute onset, rapid deterioration and significant morbidity and mortality. Most often described as a post-infectious complication of an upper respiratory illness, its precise pathophysiology remains unclear. ...

Last Updated: 28 Jan 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.