Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 769 free, full-text research articles on human participants. First 3 results:

Whole exome sequencing detects CHST3 mutation in patient with acute promyelocytic leukemia: A case report.
 

Author(s): Lili Feng, Ying Li, Ying Li, Yujie Jiang, Na Wang, Dai Yuan, Juan Fan

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12214.

 

Acute promyelocytic leukemia (APL) is a kind of acute myeloid leukemia, which was characterized by the presence of PML/RARα fusion gene. Mutations in CHST3 have been previously reported to be associated with a rare phenotype of skeleton dysplasia, known as Spondyloepiphyseal dysplasia. ...

Last Updated: 31 Dec 1969

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Hyperfibrinolysis Is an Important Cause of Early Hemorrhage in Patients with Acute Promyelocytic Leukemia.
 

Author(s): Yu-Hua Song, Chun Qiao, Li-Chan Xiao, Run Zhang, Hua - Lu

Journal:

 

BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in ...

Last Updated: 31 Dec 1969

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A Rare Case of Relapsed Pediatric Acute Promyelocytic Leukemia with Skin Involvement by Myeloid Sarcoma.
 

Author(s): Nathalia Silva Araújo, Claudio José Dos Santos Júnior, Vitória Mikaelly da Silva Gomes, Luiz Arthur Calheiros Leite, Luana Novaes Bomfim, Amanda Katielly Firmino da Silva Gusmão, Maria Jordana Rocha Gomes Alves, Cyndi Myrelle da Silva Barros Romão, Arthur Moacir Costa Sampaio Batinga, Maria Rosa da Silva, Célio Fernando de Sousa Rodrigues

Journal:

 

BACKGROUND Acute promyelocytic leukemia (APL) is a very rare leukemia in children. Extramedullary involvement by APL has been reported in between 3-5% of cases, mainly associated with cases of relapse. A rare case of relapse of APL in a 9-year-old child is presented with skin involvement ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 72 free, full-text review articles on human participants. First 3 results:

Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature.
 

Author(s): Iman Abou Dalle, Samer Nassif, Ali Bazarbachi

Journal: Hematol Oncol Stem Cell Ther. 2018 Jun;11(2):99-104.

 

Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to cytokine release from blasts. Marrow ...

Last Updated: 31 Dec 1969

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Acute promyelocytic leukemia with cryptic t(15;17) on isochromosome 17: a case report and review of literature.
 

Author(s): Yuting Tang, Ying Wang, Liang Hu, Fankai Meng, Danmei Xu, Kai Wan, Lifang Huang, Chunrui Li, Jianfeng Zhou

Journal:

 

Acute Promyelocytic Leukemia (APL) is one of the most curable leukemia which shows great sensitivity to all-trans retinoic acid (ATRA) although a small number of the patients present poor prognosis and short survival. Isochromosome 17 in APL which usually bears an additional copy ...

Last Updated: 31 Dec 1969

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The evolution of arsenic in the treatment of acute promyelocytic leukemia and other myeloid neoplasms: Moving toward an effective oral, outpatient therapy.
 

Author(s): Lorenzo Falchi, Srdan Verstovsek, Farhad Ravandi-Kashani, Hagop M Kantarjian

Journal: Cancer. 2016 Apr;122(8):1160-8.

 

The therapeutic potential of arsenic derivatives has long been recognized and was recently rediscovered in modern literature. Early studies demonstrated impressive activity of this compound in patients with relapsed acute promyelocytic leukemia (APL). Over the last 2 decades, intravenous ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic Leukaemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 14 Aug 2018

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Long-term QoL in Acute Promyelocytic Leukemia Treated With ATO or Standard Chemotherapy
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 11 Oct 2017

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Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 26 Sep 2018

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