Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 839 free, full-text research articles on human participants. First 3 results:

Infliximab as an alternative therapy for refractory adult onset Kawasaki disease: A case report.
 

Author(s): Takeshi Kawaguchi, Yuki Rikitake, Toshihiro Tsuruda, Chihiro Kawata, Mao Rikitake, Kosho Iwao, Ayako Aizawa, Yumi Kariya, Motohiro Matsuda, Syunichi Miyauchi, Kunihiko Umekita, Ichiro Takajo, Akihiko Okayama

Journal: Medicine (Baltimore). 2018 Oct;97(40):e12720.

 

Kawasaki disease (KD) is an acute febrile illness predominantly affecting children less than 5 years of age and characterized by systemic inflammation in all medium-sized arteries. Adult-onset KD (AKD) is rare with only 105 case reports published. Recently, the efficacy of infliximab ...

Last Updated: 31 Dec 1969

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miR-27b Suppresses Endothelial Cell Proliferation and Migration by Targeting Smad7 in Kawasaki Disease.
 

Author(s): Xing Rong, Donghui Ge, Danping Shen, Xianda Chen, Xuliang Wang, Lu Zhang, Chang Jia, Jingjing Zeng, Yue'e He, Huixian Qiu, Xiaoping Su, Maoping Chu

Journal: Cell. Physiol. Biochem.. 2018 ;48(4):1804-1814.

 

Increasing evidence indicates that microRNAs (miRNAs) play important roles in Kawasaki disease (KD). Our previous study demonstrated that hsa-miR-27b-3p (miR-27b) was up-regulated in KD serum. However, the specific role of miR-27b in KD remains unclear. We aimed to investigate that ...

Last Updated: 31 Dec 1969

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Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions.
 

Author(s): Dima Chbeir, Jean Gaschignard, Ronan Bonnefoy, Constance Beyler, Isabelle Melki, Albert Faye, Ulrich Meinzer

Journal:

 

Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels. Intensified treatments for the most severely affected patients have been proposed recently, and the early identification of KD patients at high risk for coronary artery aneurysms ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 71 free, full-text review articles on human participants. First 3 results:

Kawasaki Disease in the neonate: case report and literature review.
 

Author(s): Fajer Altammar, Bianca Lang

Journal:

 

Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD.

Last Updated: 31 Dec 1969

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Predictors of intravenous immunoglobulin-resistant Kawasaki disease in children: a meta-analysis of 4442 cases.
 

Author(s): Xuan Li, Ye Chen, Yunjia Tang, Yueyue Ding, Qiuqin Xu, Lin Sun, Weiguo Qian, Guanghui Qian, Liqiang Qin, Haitao Lv

Journal: Eur. J. Pediatr.. 2018 Aug;177(8):1279-1292.

 

The purpose of this study was to identify the clinical features and laboratory factors that are predictive of intravenous immunoglobulin (IVIG)-resistant Kawasaki disease. Multiple databases were searched for relevant studies on IVIG-resistant Kawasaki disease published from January ...

Last Updated: 31 Dec 1969

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[Prolonged optic disc swelling in Kawasaki disease - A case report and literature review].
 

Author(s): Yusuke Tsumura, Hiroshi Masuda, Sachiko Nishina, Tohru Kobayashi, Hiroshi Ono, Hitoshi Kato, Jun Abe, Akira Ishiguro

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2017 ;40(5):377-381.

 

  Kawasaki disease (KD), an acute childhood panvasculitis, presents a variety of ocular complications as well as conjunctival injection among the principal symptoms. However, most pediatricians are unfamiliar with the ophthalmological complications of KD. A 2-year-old girl was referred ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Mar 2018

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Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 24 Oct 2017

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KIDCARE (Kawasaki Disease Comparative Effectiveness Trial)
 

Status: Recruiting

Condition Summary: Mucocutaneous Lymph Node Syndrome

 

Last Updated: 21 Feb 2017

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