Adenoid cystic carcinoma

Common Name(s)

Adenoid cystic carcinoma

Adenoid cystic carcinoma is a rare type of cancer that usually develops in the salivary glands, which are the areas of the body where saliva is produced. Although less common, adenoid cystic carcinoma can also grow inside the breasts, eyes, lungs, brain, throat, and paranasal sinuses. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis.

Adenoid cystic carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can appear in all age groups. The most common symptom of adenoid cystic carcinoma is painless swelling on the face, neck, or mouth area. This cancer may also cause facial pain and nerve paralysis, which results in difficulty displaying facial expressions. Depending on the size of the cancer, affected individuals may also experience difficulty with vision or breathing. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for adenoid cystic carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with adenoid cystic carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid cystic carcinoma" returned 352 free, full-text research articles on human participants. First 3 results:

Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study.
 

Author(s): Dai-Qiao Ouyang, Li-Zhong Liang, Guang-Sen Zheng, Zun-Fu Ke, De-Sheng Weng, Wei-Fa Yang, Yu-Xiong Su, Gui-Qing Liao

Journal: Medicine (Baltimore). 2017 Feb;96(5):e5964.

 

Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim of this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, and survival in ACC.A retrospective review of ...

Last Updated: 2 Feb 2017

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Adenoid Cystic Carcinoma of Bartholin's Gland: Case Report.
 

Author(s): Mazdak Momeni, Yelena Korotkaya, Gonzalo Carrasco, Monica Prasad-Hayes

Journal: Acta Med Iran. 2016 Dec;54(12):820-822.

 

Primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a rare gynecologic malignancy. We report a case of locally advanced ACC of Bartholin's gland. A 62-year-old presented with left Bartholin's gland carcinoma and underwent left radical vulvectomy, left-sided inguinal-femoral ...

Last Updated: 25 Jan 2017

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Characterization and localization of c-kit and epidermal growth factor receptor in different patterns of adenoid cystic carcinoma.
 

Author(s): Anshi Jain, Devi Charan Shetty, Ajit Singh Rathore, Kiran Kumar

Journal: J Cancer Res Ther. ;12(2):834-9.

 

Adenoid cystic carcinoma (ACC) is malignant neoplasm of the salivary glands. It accounts for most cases of minor salivary gland malignancies and a substantial proportion of parotid and submandibular gland malignancies. ACC is associated with a high mortality rate, and it often recurs ...

Last Updated: 27 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid cystic carcinoma" returned 45 free, full-text review articles on human participants. First 3 results:

Adenoid cystic carcinoma of the palate: case report and review of literature.
 

Author(s): Uday Shankar Yaga, Nishanth Gollamudi, Ashwini Kumar Mengji, Radhika Besta, Prashanth Panta, Bhanu Prakash, Edunuri Rajashekar

Journal:

 

Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, ...

Last Updated: 19 Sep 2016

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Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.
 

Author(s): Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D R Thompson, Asterios Triantafyllou, Michelle D Williams, Kenneth O Devaney, Douglas R Gnepp, Justin A Bishop, Bruce M Wenig, Carlos Suárez, Juan P Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P Shah, Marc Hamoir, Patrick J Bradley, Carl E Silver, Pieter J Slootweg, Vincent Vander Poorten, Afshin Teymoortash, Jesus E Medina, K Thomas Robbins, Karen T Pitman, Luiz P Kowalski, Remco de Bree, William M Mendenhall, Jean Anderson Eloy, Robert P Takes, Alessandra Rinaldo, Alfio Ferlito

Journal: Adv Ther. 2016 Mar;33(3):357-68.

 

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon ...

Last Updated: 16 Apr 2016

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Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review.
 

Author(s): Deniz Turgut Coban, Muhammet Kazim Erol, Dinc Suren, Birsel Tutus

Journal: Arq Bras Oftalmol. ;78(5):323-5.

 

Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare malignant epithelial tumor most commonly observed in the scalp and skin of the chest and originating from the palpebral portion of the lacrimal gland in the orbit. Here we describe the diagnosis and treatment of a rare case ...

Last Updated: 15 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma
 

Status: Not yet recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 21 Mar 2017

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Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 23 Apr 2013

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Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 2 Mar 2017

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