Pheochromocytoma

Common Name(s)

Pheochromocytoma, Adrenal gland tumor

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

Last Updated: 5 Jan 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

http://www.vhl.org

Last Updated: 5 Jan 2015

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 809 free, full-text research articles on human participants. First 3 results:

Validation of pathological grading systems for predicting metastatic potential in pheochromocytoma and paraganglioma.
 

Author(s): Jung-Min Koh, Seong Hee Ahn, Hyeonmok Kim, Beom-Jun Kim, Tae-Yon Sung, Young Hoon Kim, Suck Joon Hong, Dong Eun Song, Seung Hun Lee

Journal:

 

The Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP) was proposed for predicting the metastatic potential of pheochromocytoma and paraganglioma to overcome the limitations of the Pheochromocytoma of the Adrenal Scaled Score (PASS). However, to date, no study validating ...

Last Updated: 31 Dec 1969

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A Case Report of Cystic Pheochromocytoma.
 

Author(s): Shoaib Z Junejo, Sandeep Tuli, David M Heimann, Issac Sachmechi, David Reich

Journal:

 

BACKGROUND Pheochromocytoma is a rare catecholamine-producing tumor with an estimated incidence of less than 0.1% in the global population. We present a case of cystic pheochromocytoma that was diagnosed as an incidental finding. The patient presented with abdominal pain and had a ...

Last Updated: 31 Dec 1969

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Comparison of phenoxybenzamine and doxazosin in perioperative management of patients with pheochromocytoma.
 

Author(s): Klaudia Malec, Piotr Miśkiewicz, Agnieszka Witkowska, Ewa Krajewska, Sadegh Toutounchi, Zbigniew Gałązka, Mariusz Piotrowski, Agata Kącka, Tomasz Bednarczuk, Urszula Ambroziak

Journal: Kardiol Pol. 2017 ;75(11):1192-1198.

 

Adrenalectomy with preoperative pharmacological preparation is strongly recommended in patients diagnosed with pheochromocytoma, in order to prevent perioperative complications.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 120 free, full-text review articles on human participants. First 3 results:

Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report.
 

Author(s): Shuzhong Liu, An Song, Xi Zhou, Xiangyi Kong, William A Li, Yipeng Wang, Yong Liu

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8535.

 

We present a rare case of malignant pheochromocytoma with thoracic metastases during pregnancy that presented with symptoms of myelopathy and was treated with circumferential decompression, stabilization, and radiation. The management of this unique case is not well documented. The ...

Last Updated: 31 Dec 1969

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Clinical and Molecular Features of Renal and Pheochromocytoma/Paraganglioma Tumor Association Syndrome (RAPTAS): Case Series and Literature Review.
 

Author(s): Ruth T Casey, Anne Y Warren, Jose Ezequiel Martin, Benjamin G Challis, Eleanor Rattenberry, James Whitworth, Katrina A Andrews, Thomas Roberts, Graeme R Clark, Hannah West, Philip S Smith, France M Docquier, Fay Rodger, Vicki Murray, Helen L Simpson, Yvonne Wallis, Olivier Giger, Maxine Tran, Susan Tomkins, Grant D Stewart, Soo-Mi Park, Emma R Woodward, Eamonn R Maher

Journal: J. Clin. Endocrinol. Metab.. 2017 Nov;102(11):4013-4022.

 

The co-occurrence of pheochromocytoma (PC) and renal tumors was linked to the inherited familial cancer syndrome von Hippel-Lindau (VHL) disease more than six decades ago. Subsequently, other shared genetic causes of predisposition to renal tumors and to PC, paraganglioma (PGL), or ...

Last Updated: 31 Dec 1969

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Pheochromocytoma: The First Metabolic Endocrine Cancer.
 

Author(s): Ivana Jochmanova, Karel Pacak

Journal: Clin. Cancer Res.. 2016 Oct;22(20):5001-5011.

 

Dysregulated metabolism is one of the key characteristics of cancer cells. The most prominent alterations are present during regulation of cell respiration, which leads to a switch from oxidative phosphorylation to aerobic glycolysis. This metabolic shift results in activation of ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 27 Dec 2017

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MIBG for Refractory Neuroblastoma and Pheochromocytoma
 

Status: Recruiting

Condition Summary: Relapsed Neuroblastoma; Metastatic Pheochromocytoma

 

Last Updated: 3 Dec 2017

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Last Updated: 29 Jan 2018

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