Adrenocortical Carcinoma

Common Name(s)

Adrenocortical Carcinoma

Adrenocortical carcinoma is a rare cancer, which comes from the adrenal gland. There are two adrenal glands in the human body, one on the top of each kidney in the abdomen. They are shaped like triangles, and each is about a ½ inch high and 3 inches long.

There are two main types of adrenocortical cancer:

Functioning is the most common type and accounts for about 70 percent of adrenal cancers. These tumors are "functioning" because they make hormones, which may have various effects on the body such as facial hair growth, increased blood pressure, or weight gain.

Non-functioning tumors do not produce hormones.

Adrenocortical carcinoma is a rare cancer, affecting only about 300 to 500 people each year in the United States.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

Last Updated: 9 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adrenocortical Carcinoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
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NET Patient Foundation

The Charity’s objects (“the Objects”) are: 1. to advance the education of the general public (including relevant medical and scientific communities) in all areas relating to NETs. 2. to promote the physical and mental health of those affected by NETs through the provision of support, advice and education to patients, their carers and family members.

http://www.netpatientfoundation.org

Last Updated: 9 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adrenocortical Carcinoma" returned 276 free, full-text research articles on human participants. First 3 results:

Adjuvant radiotherapy for the primary treatment of adrenocortical carcinoma: Are we offering the best?
 

Author(s): Victor Srougi, Jose de Bessa, Fabio Y Tanno, Amanda M Ferreira, Ana O Hoff, João E Bezerra, Cristiane M Almeida, Madson Q Almeida, Berenice B Mendonça, William C Nahas, Jose L Chambô, Miguel Srougi, Maria C B V Fragoso

Journal: Int Braz J Urol. ;43(5):841-848.

 

To evaluate the role of ARDT after surgical resection of ACC.

Last Updated: 31 Dec 1969

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The efficacy of radiation therapy in adrenocortical carcinoma: A propensity score analysis of a population-based study.
 

Author(s): You Luo, San-San Chen, Xiang-Guang Zheng, Li Luo, Sen Wang

Journal: Medicine (Baltimore). 2017 Apr;96(17):e6741.

 

Adrenocortical carcinoma (ACC) is a rare and malignant tumor. The main treatment is primary surgical resection with or without mitotane therapy. The role of radiation therapy is still controversial. We aim to investigate the survival efficacy of radiotherapy in a large population-based ...

Last Updated: 31 Dec 1969

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Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma.
 

Author(s): Yi Zhu, Minjie Wang, Xu Zhao, Lei Zhang, Yigao Wu, Bangqi Wang, Weilie Hu

Journal: Oncotarget. 2017 Apr;8(14):22825-22834.

 

Adrenocortical carcinoma (ACC) is a rare, but aggressive endocrine malignancy with a generally poor clinical outcome. There is no effective therapy for advanced and metastatic ACC. In our study, we found that an existing drug (rottlerin) exerted its tumour-suppressive function in ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adrenocortical Carcinoma" returned 37 free, full-text review articles on human participants. First 3 results:

Adrenocortical Oncocytic Carcinoma: A Case Report and Review of the Histopathologic Diagnostic Criteria.
 

Author(s): Deniz Arik, Funda Canaz, Emine Dündar

Journal: Turk Patoloji Derg. 2016 ;32(3):211-5.

 

Oncocytic tumors are rare in the adrenal gland. The histopathological diagnosis of adrenocortical carcinoma is difficult due to the lack of precise diagnostic criteria for malignancy. A 44-year-old man was admitted to our hospital with left flank pain. Radiologically an adrenal mass ...

Last Updated: 31 Dec 1969

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Molecular pathways of human adrenocortical carcinoma - translating cell signalling knowledge into diagnostic and treatment options.
 

Author(s): Paulina Szyszka, Ashley B Grossman, Salvador Diaz-Cano, Krzysztof Sworczak, Dorota Dworakowska

Journal: Endokrynol Pol. 2016 ;67(4):427-50.

 

Adrenocortical carcinoma is associated with a low cure rate and a high recurrence rate. The prognosis is poor, and at diagnosis 30-40% of cases are already metastatic. The current therapeutic options (surgical resection, followed by adjuvant mitotane treatment +/- chemotherapy) are ...

Last Updated: 31 Dec 1969

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Assessment and management of advanced adrenocortical carcinoma using a precision oncology care model.
 

Author(s): Aymen A Elfiky, Hari K Krishnan Nair

Journal: Discov Med. 2016 Jan;21(113):49-56.

 

Within the category of orphan diseases and rare malignancies, adrenocortical carcinoma (ACC) represents an aggressive entity with high mortality and morbidity. While localized tumors which are diagnosed early can be cured with surgical intervention, there are prognostic factors which ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cabazitaxel Activity in Patients With Advanced AdrenoCortical-Carcinoma Progressing After Previous Chemotherapy Lines
 

Status: Not yet recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 23 Oct 2017

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Cabozantinib in Unresectable/Metastatic Adrenocortical Carcinoma
 

Status: Not yet recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 8 Dec 2017

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German Adrenocortical Carcinoma Registry
 

Status: Recruiting

Condition Summary: Adrenocortical Carcinoma

 

Last Updated: 28 Oct 2016

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