Aggressive Systemic Mastocytosis

Common Name(s)

Aggressive Systemic Mastocytosis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aggressive Systemic Mastocytosis" for support, advocacy or research.

The Mastocytosis Society, Inc

The Mastocytosis Society is a 501(c)3 nonprofit organization dedicated to supporting patients affected by Mastocytosis or Mast Cell Activation Disorders as well as their families, caregivers, and physicians through research, education, and advocacy.

Last Updated: 20 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Aggressive Systemic Mastocytosis" for support, advocacy or research.

The Mastocytosis Society, Inc

The Mastocytosis Society is a 501(c)3 nonprofit organization dedicated to supporting patients affected by Mastocytosis or Mast Cell Activation Disorders as well as their families, caregivers, and physicians through research, education, and advocacy.

http://www.TMSforacure.org

Last Updated: 20 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Aggressive Systemic Mastocytosis" returned 7 free, full-text research articles on human participants. First 3 results:

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice.
 

Author(s): Namit Sharma, Stephanie Everingham, Li-Fan Zeng, Zhong-Yin Zhang, Reuben Kapur, Andrew W B Craig

Journal: Oncotarget. 2014 Aug;5(15):6130-41.

 

Acquired mutations in KIT are driver mutations in systemic mastocytosis (SM). Here, we tested the role of SHP2/PTPN11 phosphatase in oncogenic KIT signaling using an aggressive SM mouse model. Stable knock-down (KD) of SHP2 led to impaired growth, colony formation, and increased rates ...

Last Updated: 31 Dec 1969

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Eosinophilia and bone lesion as clinical manifestations of aggressive systemic mastocytosis.
 

Author(s): Emiko Sakane-Ishikawa, Taiichi Kodaka, Hiroko Tsunemine, Kiminari Itoh, Hiroshi Akasaka, Toshiyuki Kusama, Kisako Imaizumi, Masanori Taketomi, Akiko Sada, Yoshio Katayama, Tomoo Itoh, Takayuki Takahashi

Journal: J Clin Exp Hematop. 2013 ;53(3):207-13.

 

We report a patient with aggressive systemic mastocytosis (SM), who exhibited eosinophilia and unusual destructive bone lesions. A 43-year-old female was referred to our hospital because of a vertebral compression fracture, multiple lytic bone lesions, and eosinophilia in February ...

Last Updated: 31 Dec 1969

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Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor.
 

Author(s): Sophie Georgin-Lavialle, Ludovic Lhermitte, Cédric Baude, Stéphane Barete, Julie Bruneau, Jean-Marie Launay, Marie-Olivia Chandesris, Katia Hanssens, Christian de Gennes, Gandhi Damaj, Fanny Lanternier, Mohamed Hamidou, Olivier Lortholary, Patrice Dubreuil, Frédéric Feger, Yves Lepelletier, Olivier Hermine

Journal: Blood. 2011 Nov;118(19):5246-9.

 

Mastocytosis is a heterogeneous disease characterized by the accumulation of mast cells in one or more organs. Our objective was to identify a peripheral mast cell precursor and assess its variation rate in mastocytosis. A peripheral blood phenotypic analysis was performed among 50 ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Aggressive Systemic Mastocytosis" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumors; Aggressive Systemic Mastocytosis; Advanced Cancers

 

Last Updated: 29 Jan 2018

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Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (advSM) and Relapsed or Refractory Myeloid Malignancies
 

Status: Recruiting

Condition Summary: Aggressive Systemic Mastocytosis; Systemic Mastocytosis-associated Hematologic Non-mast Cell Disease; Mast Cell Leukemia; Relapsed or Refractory Myeloid Malignancies

 

Last Updated: 22 Feb 2018

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Mast Cell Connect: A Registry for Patients With Mastocytosis
 

Status: Recruiting

Condition Summary: Mastocytosis

 

Last Updated: 19 Sep 2017

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