Autoimmune Inner Ear disease

Common Name(s)

Autoimmune Inner Ear disease

Autoimmune Inner Ear disease (AIED) is a condition in which the body’s immune system mistakenly attacks cells in the inner ear, which causes inflammation. Symptoms may include: sudden hearing loss (usually starting in one ear and spreading to the other), vertigo, and ringing, hissing, or roaring sounds in the ear. Seventy nine percent of patients experience hearing loss in both ears. AIED occurs in both men and women, but is more common in women. The average age of onset is between 20 and 50 years old, and cases in young children are uncommon. AIED can be diagnosed using tests to assess hearing loss or loss of balance, in addition to blood tests for general autoimmune diseases. Treatment may include use of steroids or hearing aids, gene therapy, or cochlear implant.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Inner Ear disease" for support, advocacy or research.

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Vestibular Disorders Association

VEDA's mission is to serve people with vestibular (inner ear balance) disorders by providing access to information, offering a support network, and elevating awareness of the challenges associated with these conditions.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Autoimmune Inner Ear disease" for support, advocacy or research.

Logo
Vestibular Disorders Association

VEDA's mission is to serve people with vestibular (inner ear balance) disorders by providing access to information, offering a support network, and elevating awareness of the challenges associated with these conditions.

https://vestibular.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Autoimmune Inner Ear disease" returned 8 free, full-text research articles on human participants. First 3 results:

The Balance of Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Autoimmune Inner Ear Disease Patients.
 

Author(s): Logan Eisner, Andrea Vambutas, Shresh Pathak

Journal: J. Interferon Cytokine Res.. 2017 Aug;37(8):354-361.

 

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a protein implicated in the control of inflammation in a number of autoimmune diseases. We hypothesized that the balance of TIMP-1 and matrix metalloproteinase-9 (MMP-9) may influence the control or perpetuation of inflammation in ...

Last Updated: 31 Dec 1969

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N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients.
 

Author(s): Shresh Pathak, Corey Stern, Andrea Vambutas

Journal: Immunol. Res.. 2015 Dec;63(1-3):236-45.

 

Autoimmune inner ear disease (AIED) is a poorly understood disease marked by bilateral, rapidly progressive hearing loss triggered by unknown stimuli, which is corticosteroid responsive in 60 % of patients. Although the mechanism of the disease is not precisely understood, a complex ...

Last Updated: 31 Dec 1969

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Diffuse systemic sclerosis presenting as Meniere's disease-like symptoms as part of autoimmune inner ear disease.
 

Author(s): Joy Feld, Avi Shupak, Devy Zisman

Journal: Isr. Med. Assoc. J.. 2015 Apr;17(4):263-4.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Autoimmune Inner Ear disease" returned 3 free, full-text review articles on human participants. First 3 results:

Cogan's syndrome: an autoimmune inner ear disease.
 

Author(s): A Greco, A Gallo, M Fusconi, G Magliulo, R Turchetta, C Marinelli, G F Macri, A De Virgilio, M de Vincentiis

Journal: Autoimmun Rev. 2013 Jan;12(3):396-400.

 

The objective of our study was to review our current knowledge of the aetiopathogenesis of Cogan's syndrome, including viral infection and autoimmunity, and to discuss disease pathogenesis with relevance to pharmacotherapy.

Last Updated: 31 Dec 1969

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Immunosuppressive therapy for autoimmune inner ear disease.
 

Author(s): Maria C Buniel, Katie Geelan-Hansen, Peter C Weber, Vincent K Tuohy

Journal: Immunotherapy. 2009 May;1(3):425-34.

 

Autoimmune inner ear disease (AIED) is a rare disease that is diagnosed after clinical suspicion and response to corticosteroids. AIED manifests as progressive, bilateral, although often asynchronous, sensorineural hearing loss and can be associated with vestibular symptoms. Since ...

Last Updated: 31 Dec 1969

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Biological and clinical aspects of autoimmune inner ear disease.
 

Author(s): A J Griffith

Journal: Yale J Biol Med. ;65(1):17-28.

 

The clinical presentation, diagnosis, and management of autoimmune inner ear disease are reviewed. Recent studies indicating an autoimmune etiology and pathogenesis are discussed, along with a comparative analysis of several promising new animal models. Further studies to define the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Anakinra in Subjects With Autoimmune Inner Ear Disease
 

Status: Not yet recruiting

Condition Summary: Autoimmune Inner Ear Disease

 

Last Updated: 13 Jul 2018

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