Autoimmune Polyglandular Syndrome Type 3 (PAS III) is when glands in the body do not properly produce hormones. This can occur at any age, but is more common in middle-aged women.
PAS IIII affects the thyroid gland, which is a gland under the skin on the side of the neck and directly below the jaw line. The individual may have a large, hard, and bumpy feeling gland. This syndrome may affect other glands or organs as well. Common symptoms include dry skin, dehydration, pale appearance, or hair loss. It is important to determine which form of PAS an individual might have.
Autoimmune polyglandular syndrome type 3 follows an autosomal dominant inheritance. Genes are inherited in pairs, one from each parent. Genes control the growth, development and function of our bodies. If a mistake or error occurs in a gene, it can cause problems. This syndrome is associated with HLA class II genes. Autosomal dominant means an individual only needs one copy of the changed (mutated) gene from one parent to cause the condition.
Autoimmune polyglandular syndrome type 3 can be diagnosed early when enlarged glands or improper functioning of a gland is noticed. Treatment includes watching glands, taking additional hormones, or other specific treatment depending on which glands or organs are affected. If you or a family member has been diagnosed with Autoimmune Polyglandular Syndrome Type 3, talk with your doctor about the most current treatment options as well as signs that you may need immediate medical attention. Support groups are also good sources for support and information that you may consider contacting.