Avascular necrosis of femoral head, primary

Common Name(s)

Avascular necrosis of femoral head, primary

Avascular necrosis of the femoral head (ANFH) is a debilitating disease that usually leads to destruction of the hip joint in the third to fifth decade of life. The disorder is characterized by progressive pain in the groin, mechanical failure of the subchondral bone, and degeneration of the hip joint. Nearly one-half of patients require hip replacement before 40 years of age. ANFH represents a specific form of the broader disease category of osteonecrosis (summary by {11:Mont and Hungerford, 1995}). Genetic Heterogeneity of Primary Avascular Necrosis of the Femoral Head ANFH2 is caused by mutation in the TRPV4 gene ({605427}) on chromosome 12q24. Mutation in COL2A1 has also been found in Legg-Calves-Perthes disease (LCPD; {150600}), a form of ANFH in growing children.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Avascular necrosis of femoral head, primary" for support, advocacy or research.

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Scientific Literature

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Research articles describe the outcome of a single study. They are the published results of original research.
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The terms "Avascular necrosis of femoral head, primary" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells
 

Status: Not yet recruiting

Condition Summary: Osteonecrosis of Femoral Head

 

Last Updated: 8 Jun 2017

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Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip
 

Status: Recruiting

Condition Summary: Osteonecrosis of Femoral Head; Osteonecrosis; Aseptic, Idiopathic

 

Last Updated: 22 Jan 2018

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