Balo's concentric sclerosis

Common Name(s)

Balo's concentric sclerosis, Balo disease, Encephalitis periaxialis concentrica, Leukoencephalitis periaxialis concentrica

Balo's concentric sclerosis also known as, Balo disease, is a rare and progressive (worsening) variation of multiple sclerosis (see also: Multiple sclerosis.). It is considered a demyelinating disease. Myelin is the protective covering or insulation over the nerves in the brain and brain stem. In demyelinating disease, the myelin becomes damaged. This damage impacts the way the nerves in the body send and receive signals. The damage in Balo disease mainly affects sensation, movement and cognition (mental abilities). It usually presents itself in adulthood, however rare childhood cases have been reported. In contrast to multiple sclerosis, which tends to follow an intermittent course (a period of symptoms followed by a period of no symptoms), Balo disease usually follows a more rapidly progressive course. Depending upon the part of the brain that is damaged, symptoms will vary. Symptoms may include headaches, seizures, partial paralysis (loss of muscle function), decreased mental strength (cognitive decline), and muscle spasms. Symptoms may progress rapidly over a few weeks or more slowly over two to three years.

The cause of Balo disease is not known, but it is possibly a result of autoimmune factors that are essential in development. Autoimmune diseases occur when your body mistakes its own healthy tissues as foreign (not its own) and starts attacking it. Balo disease is diagnosed by looking for specific findings on brain MRI. It is more common in the Asian and Philippine populations and affects men and women equally. Today, there is no cure for Balo disease nor is there specific treatment. Symptoms are handled on a case by case basis. It is important to talk with your doctor or specialist in order to best manage the disease. Many multiple sclerosis support groups welcome patients with Balo disease.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Balo's concentric sclerosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Balo's concentric sclerosis" returned 13 free, full-text research articles on human participants. First 3 results:

Morphogenesis of the demyelinating lesions in Baló's concentric sclerosis.
 

Author(s): Helmut Barz, Ulrich Barz, Almut Schreiber

Journal: Med. Hypotheses. 2016 Jun;91():56-61.

 

In tissues with elastic properties, an edema causes a raised tissue pressure and therefore a diminished blood flow. The authors assume that an increased tissue pressure due to local and/or relapsing edema may be the cause for incomplete necrosis (e.g. demyelinated lesions) or seldom ...

Last Updated: 4 May 2016

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Enhanced T 2 FNx weighted angiography imaging and 3-D time-resolved imaging of contrast kinetics findings in Balo's concentric sclerosis.
 

Author(s): Chun Zeng, Junwei Xiong, Yongmei Li, Yu Ouyang, Fajin Lv, Reshiana Rumzan, Zubin Ouyang

Journal: Neurol India. ;62(3):304-6.

 

Last Updated: 18 Jul 2014

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Baló's concentric sclerosis: imaging findings and pathological correlation.
 

Author(s): Maxine Darke, Farshad M Bahador, Douglas C Miller, Norman S Litofsky, Humera Ahsan

Journal:

 

Baló's concentric sclerosis is a primary inflammatory central nervous system demyelinating disease that is considered a rare, radiographically and pathologically distinct variant of multiple sclerosis. Baló's concentric sclerosis is characterized by alternating rings of demyelinated ...

Last Updated: 14 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Balo's concentric sclerosis" returned 1 free, full-text review articles on human participants. First 3 results:

Balo's concentric sclerosis involving bilateral thalami.
 

Author(s): Farheen Badar, Shah F Azfar, Ibne Ahmad, Sanna Kirmani, Muddassir Rashid

Journal: Neurol India. ;59(4):597-600.

 

Balo's concentric sclerosis (BCS) is a rare inflammatory demyelinating disease of central nervous system, pathologically characterized by alternate bands of demyelination and preserved myelin tissue. Before the era of magnetic resonance imaging (MRI), most cases of BCS were diagnosed ...

Last Updated: 5 Sep 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpers Huttenlocher Natural History Study
 

Status: Recruiting

Condition Summary: Alpers Huttenlocher Syndrome

 

Last Updated: 25 Jan 2017

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