Baroreflex failure

Common Name(s)

Baroreflex failure

Baroreflex failure is a rare condition in which individuals experience blood pressure changes including periods of severely high blood pressure (hypertension) during times of stress alternating with normal or low blood pressure (hypotension) at rest. Symptoms for baroreflex failure may include headaches, excessive sweating, heart rate that is unchanged by medications, extremely high blood pressure and heart rate with stress and low blood pressure at rest. In many cases, the cause of baroreflex failure is unknown. However, it can be caused when there is damage to the nerves in the neck that should sense blood pressure. Causes can include damage from surgery to this region, after radiation cancer treatment involving the neck, or certain types of strokes. Unfortunately, baroreflex failure is hard to diagnose as it mirrors other more common disorders. In order to properly diagnose the condition, physicians monitor one’s heart rate and blood pressure during daily activities and other specific testing options. Upon diagnosis, treatment is the use of medications used to manage blood pressure, stress, and heart rate. If you have experienced any of these causes or suspect that you might have baroreflex failure, contact your physician. If you have been diagnosed with baroreflex failure, talk with your doctor and specialists about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Baroreflex failure" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Baroreflex failure" returned 36 free, full-text research articles on human participants. First 3 results:

Restoration of normal sympathetic neural function in heart failure following baroreflex activation therapy: final 43-month study report.
 

Author(s): Raffaella Dell'Oro, Edoardo Gronda, Gino Seravalle, Giuseppe Costantino, Luca Alberti, Barbara Baronio, Tiziana Staine, Emilio Vanoli, Giuseppe Mancia, Guido Grassi

Journal: J. Hypertens.. 2017 Dec;35(12):2532-2536.

 

Baroreflex activation therapy (BAT) exerts in severe heart failure sympathoinhibitory effects, improving clinical variables and reducing hospitalization rate. The current follow-up study was aimed at determining the long-term effects of BAT, assessing whether BAT in heart failure ...

Last Updated: 31 Dec 1969

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Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction.
 

Author(s): Fred A Weaver, William T Abraham, William C Little, Christian Butter, Anique Ducharme, Marcel Halbach, Didier Klug, Eric G Lovett, Navid Madershahian, Jochen Müller-Ehmsen, Jill E Schafer, Michele Senni, Vijay Swarup, Rolf Wachter, Michael R Zile

Journal: Semin. Thorac. Cardiovasc. Surg.. ;28(2):320-328.

 

The purpose of this publication is to describe the intraoperative experience along with long-term safety and efficacy of the second-generation baroreflex activation therapy (BAT) system in patients with heart failure (HF) and reduced ejection fraction HF (HFrEF). In a randomized trial ...

Last Updated: 31 Dec 1969

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Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study.
 

Author(s): Imad Libbus, Bruce D Nearing, Badri Amurthur, Bruce H KenKnight, Richard L Verrier

Journal: Heart Rhythm. 2016 Mar;13(3):721-8.

 

Autonomic regulation therapy (ART) with chronic vagus nerve stimulation improves ventricular function in patients with chronic heart failure, but its effects on quantitative T-wave alternans (TWA), ventricular tachycardia (VT), baroreflex sensitivity, and autonomic tone remained unknown.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Baroreflex failure" returned 5 free, full-text review articles on human participants. First 3 results:

Baroreflex activation therapy: a new approach to the management of advanced heart failure with reduced ejection fraction.
 

Author(s): Edoardo Gronda, Darrel Francis, Faiez Zannad, Christian Hamm, Josep Brugada, Emilio Vanoli

Journal: J Cardiovasc Med (Hagerstown). 2017 Sep;18(9):641-649.

 

: Chronic heart failure is a common clinical condition characterized by persistent excessive sympathetic nervous system activation. The derangement of the sympathetic activity has relevant implications for disease progression and patient survival. Aiming to positively impact patient ...

Last Updated: 31 Dec 1969

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Baroreflex activation for the treatment of heart failure.
 

Author(s): Hani N Sabbah

Journal: Curr Cardiol Rep. 2012 Jun;14(3):326-33.

 

Autonomic dysregulation is a feature of heart failure (HF) characterized by sustained increase of sympathetic drive and by withdrawal of parasympathetic activity. Both maladaptations are independent predictors of poor long-term outcome in patients with HF. Considerable evidence exists ...

Last Updated: 31 Dec 1969

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Baroreflex failure: a neglected type of secondary hypertension.
 

Author(s): H J L M Timmers, W Wieling, J M Karemaker, J W M Lenders

Journal: Neth J Med. 2004 May;62(5):151-5.

 

The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

UK Registry for Baroreflex Activation Therapy
 

Status: Not yet recruiting

Condition Summary: Baroreflex Failure Syndrome; Hypertension, Resistant to Conventional Therapy

 

Last Updated: 1 Nov 2018

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Carbidopa for the Treatment of Excessive Blood Pressure Variability
 

Status: Recruiting

Condition Summary: Dysautonomia, Familial; Baroreflex Failure Syndrome

 

Last Updated: 19 Jul 2018

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Barostim Neo® - Baroreflex Activation Therapy® for Heart Failure
 

Status: Recruiting

Condition Summary: Heart Failure

 

Last Updated: 22 May 2018

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