Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 581 free, full-text research articles on human participants. First 3 results:

Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels.
 

Author(s): Pierre Martinez, Diego Mallo, Thomas G Paulson, Xiaohong Li, Carissa A Sanchez, Brian J Reid, Trevor A Graham, Mary K Kuhner, Carlo C Maley

Journal:

 

The low risk of progression of Barrett's esophagus (BE) to esophageal adenocarcinoma can lead to over-diagnosis and over-treatment of BE patients. This may be addressed through a better understanding of the dynamics surrounding BE malignant progression. Although genetic diversity ...

Last Updated: 31 Dec 1969

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Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.
 

Author(s): Atsuhiro Masuda, Tsuyoshi Fujita, Manabu Murakami, Yukinao Yamazaki, Masao Kobayashi, Shuichi Terao, Tsuyoshi Sanuki, Akihiko Okada, Masayasu Adachi, Hideyuki Shiomi, Yoshifumi Arisaka, Hiromu Kutsumi, Eiji Umegaki, Takeshi Azuma

Journal:

 

The association of alcohol intake with the incidence of Barrett's esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown.

Last Updated: 31 Dec 1969

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Circular stripes were more common in Barrett's esophagus after acetic acid staining.
 

Author(s): Yating Sun, Shiyang Ma, Li Fang, Jinhai Wang, Lei Dong

Journal:

 

The diagnosis of Barrett's esophagus (BE) is disturbed by numerous factors, including correct gastroesophageal junction judgment, the initial location of the Z-line and the biopsy result above it. The acetic acid (AA) could help to diagnose BE better than high resolution imaging technology ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 114 free, full-text review articles on human participants. First 3 results:

Barrett's Esophagus - State of the Art.
 

Author(s): Marcel Tanţău, Mihaela Laszlo, Alina Tanţău

Journal: Chirurgia (Bucur). ;113(1):46-60.

 

Barrett's Esophagus (BE) is defined as a premalignant condition, where the esophageal squamous epithelium is replaced by intestinal epithelium. Specialized intestinal columnar metaplasia, typical for Barrett's esophagus, does not generate any symptoms. Most of the patients are initially ...

Last Updated: 31 Dec 1969

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Volumetric Laser Endomicroscopy for Barrett's Esophagus - Looking at the Fine Print.
 

Author(s): Deepanshu Jain, Sanna Fatima, Shilpa Jain, Shashideep Singhal

Journal: J Gastrointestin Liver Dis. 2017 Sep;26(3):291-297.

 

Barrett's esophagus (BE) is a premalignant condition. The incidence of adenocarcinoma in BE has been reported to be between 0.1-3%. Dysplasia in BE is patchy and extensive biopsy sampling is labor intensive, low yield and does not eliminate the sampling error completely. Volumetric ...

Last Updated: 31 Dec 1969

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The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.
 

Author(s): Gianmarco Contino, Thomas L Vaughan, David Whiteman, Rebecca C Fitzgerald

Journal: Gastroenterology. 2017 09;153(3):657-673.e1.

 

We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 10 Mar 2017

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BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 24 Jan 2017

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Last Updated: 12 Mar 2018

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