Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 599 free, full-text research articles on human participants. First 3 results:

Selection and Application of Tissue microRNAs for Nonendoscopic Diagnosis of Barrett's Esophagus.
 

Author(s): Xiaodun Li, Sam Kleeman, Sally B Coburn, Carlo Fumagalli, Juliane Perner, Sriganesh Jammula, Ruth M Pfeiffer, Linda Orzolek, Haiping Hao, Philip R Taylor, Ahmad Miremadi, Núria Galeano-Dalmau, Pierre Lao-Sirieix, Maria Tennyson, Shona MacRae, Michael B Cook, Rebecca C Fitzgerald

Journal: Gastroenterology. 2018 09;155(3):771-783.e3.

 

MicroRNA (miRNA) is highly stable in biospecimens and provides tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to discover a set of miRNAs that could accurately discriminate Barrett's esophagus (BE) from normal esophageal tissue and to test its diagnostic ...

Last Updated: 31 Dec 1969

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Length of Barrett's segment predicts failure of eradication in radiofrequency ablation for Barrett's esophagus: a retrospective cohort study.
 

Author(s): Tyler Luckett, Chaitanya Allamneni, Kevin Cowley, John Eick, Allison Gullick, Shajan Peter

Journal:

 

We aim to investigate factors that may contribute to failure of eradication of dysplastic Barrett's Esophagus among patients undergoing radiofrequency ablation treatment.

Last Updated: 31 Dec 1969

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Dysregulation of PARP1 is involved in development of Barrett's esophagus.
 

Author(s): Chao Zhang, Teng Ma, Tao Luo, Ang Li, Xiang Gao, Zhong-Gao Wang, Fei Li

Journal: World J. Gastroenterol.. 2018 Mar;24(9):982-991.

 

To investigate the potential role of poly(ADP-ribose) polymerase 1 (PARP1) in the development of Barrett's esophagus (BE).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 120 free, full-text review articles on human participants. First 3 results:

Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett's Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives.
 

Author(s): Jolanta Majka, Mateusz Wierdak, Iwona Brzozowska, Marcin Magierowski, Aleksandra Szlachcic, Dagmara Wojcik, Slawomir Kwiecien, Katarzyna Magierowska, Jacek Zagajewski, Tomasz Brzozowski

Journal:

 

Melatonin is a tryptophan-derived molecule with pleiotropic activities which is produced in all living organisms. This "sleep" hormone is a free radical scavenger, which activates several anti-oxidative enzymes and mechanisms. Melatonin, a highly lipophilic hormone, can reach body ...

Last Updated: 31 Dec 1969

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Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta-analysis and systematic review.
 

Author(s): Bálint Erőss, Nelli Farkas, Áron Vincze, Benedek Tinusz, László Szapáry, András Garami, Márta Balaskó, Patrícia Sarlós, László Czopf, Hussain Alizadeh, Zoltán Rakonczay, Tamás Habon, Péter Hegyi

Journal: Helicobacter. 2018 Aug;23(4):e12504.

 

The prevalence of Helicobacter pylori infection (HPI) has been decreasing in developed countries, with an increasing prevalence of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) at the same time. The aim of our meta-analysis was to quantify the risk of BE in the context of HPI.

Last Updated: 31 Dec 1969

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Natural History of Barrett's Esophagus.
 

Author(s): Ernst J Kuipers, Manon C Spaander

Journal: Dig. Dis. Sci.. 2018 Aug;63(8):1997-2004.

 

Barrett's esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 10 Mar 2017

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BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 30 Oct 2018

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Last Updated: 12 Mar 2018

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