Basal cell carcinoma

Common Name(s)

Basal cell carcinoma

Basal cell carcinoma (BCC) is a slow-growing skin cancer and the most common form of cancer in the United States. The cancer starts within the outermost layer of skin, typically in areas with prolonged exposure to ultraviolet radiation from sunlight or tanning beds. Signs of BCC include skin lesions that are different in appearance, color, size, or texture than the surrounding skin. The lesion may also be painful, swollen, itchy, or bleed. The most common location where BCC is found is on the head or neck.

In the United States, there are about 800,000 new cases of BCC each year. Living in areas close to the equator, at high altitudes, or in regions with a depleted ozone increases the risk of skin damage and BCC. Risk factors for developing BCC are being over age 40, freckled skin, eye colors other than brown, blonde or red hair, a family history of skin cancer, and having previous severe sunburns. About 30% of Caucasians develop BCC in their lifetime.

When testing for BCC, a doctor will remove a piece of skin to be examined. Treatments include cutting or killing affected skin cells, applying medicated creams, and light therapy. Mohs surgery is an effective surgery for skin cancer in which a small area of the skin is removed layer-by-layer and examined until a layer without cancer is found. For BCC that cannot be treated by surgery, radiation or chemotherapy may be used.

Routine skin examinations are important in order to detect BCC early. Early treatment reduces the chances of the cancer spreading to other areas, including other organs. Certain aggressive types of BCC may be lethal if undetected. Avoiding prolonged exposure to sunlight and wearing sunscreen can help prevent BCC. If you have been diagnosed with BCC, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Basal cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Basal cell carcinoma" returned 679 free, full-text research articles on human participants. First 3 results:

[Zitelli bilobed flap for the reconstruction of the nasal pyramid after excision of basal cell carcinoma (BCC)].
 

Author(s): Karim Bourra, Samir Mazouz

Journal:

 

We report the case of a 65-year old patient presenting with well-defined nodular basal cell carcinom measuring 5mm in diameter in the right paramedian nasal tip and the superior margin of the nasal wing, near the free edge. The tumor was removed, with resection margin of 1mm. It was ...

Last Updated: 5 Oct 2017

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Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments.
 

Author(s): Cristina Pellegrini, Augusto Orlandi, Gaetana Costanza, Alessandro Di Stefani, Antonella Piccioni, Antonella Di Cesare, Andrea Chiricozzi, Amedeo Ferlosio, Ketty Peris, Maria Concetta Fargnoli

Journal:

 

Several immune-related markers have been implicated in basal cell carcinoma (BCC) pathogenesis. The BCC inflammatory infiltrate is dominated by Th2 cytokines, suggesting a specific state of immunosuppression. In contrast, regressing BCC are characterized by a Th1 immune response with ...

Last Updated: 22 Aug 2017

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Investigation of P120catenin Expression in Human Basal Cell Carcinoma of the Skin.
 

Author(s): Vladimír Bartoš, Milada Kullová

Journal: Acta Medica (Hradec Kralove). ;60(1):32-36.

 

P120(ctn) is a specific membranous adhesion protein, that maintains the stability of intercellular junctions. An altered expression of p120(ctn), either reduced in the cell membrane or increase in the cytoplasm, plays a crucial role in carcinogenesis. No research has analysed the ...

Last Updated: 7 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Basal cell carcinoma" returned 68 free, full-text review articles on human participants. First 3 results:

Molecular basis of basal cell carcinoma.
 

Author(s): Erik Montagna, Otávio Sérgio Lopes

Journal: An Bras Dermatol. ;92(4):517-520.

 

Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, ...

Last Updated: 27 Sep 2017

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Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.
 

Author(s): Mihai Lupu, Constantin Caruntu, Mihaela Adriana Ghita, Vlad Voiculescu, Suzana Voiculescu, Adrian E Rosca, Ana Caruntu, Liliana Moraru, Iris Maria Popa, Bogdan Calenic, Maria Greabu, Daniela Elena Costea

Journal: Dis. Markers. 2016 ;2016():9831237.

 

Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development ...

Last Updated: 31 Aug 2016

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Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma.
 

Author(s): Mario E Lacouture, Brigitte Dréno, Paolo Antonio Ascierto, Reinhard Dummer, Nicole Basset-Seguin, Kate Fife, Scott Ernst, Lisa Licitra, Rogerio I Neves, Ketty Peris, Susana Puig, Jonas Sokolof, Aleksandar Sekulic, Axel Hauschild, Rainer Kunstfeld

Journal: Oncologist. 2016 10;21(10):1218-1229.

 

Abnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell carcinoma (BCC). Vismodegib, a first-in-class small-molecule inhibitor of hedgehog pathway signaling, is approved by regulatory authorities for the treatment of adults who have metastatic ...

Last Updated: 11 Aug 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

RCM to Diagnose BCC - Reflectance Confocal Microscopy to Diagnose Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 1 Nov 2017

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Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 1 Mar 2017

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Topical Itraconazole in the Treatment of Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 3 Oct 2017

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