Basal cell carcinoma

Common Name(s)

Basal cell carcinoma

Basal cell carcinoma (BCC) is a slow-growing skin cancer and the most common form of cancer in the United States. The cancer starts within the outermost layer of skin, typically in areas with prolonged exposure to ultraviolet radiation from sunlight or tanning beds. Signs of BCC include skin lesions that are different in appearance, color, size, or texture than the surrounding skin. The lesion may also be painful, swollen, itchy, or bleed. The most common location where BCC is found is on the head or neck.

In the United States, there are about 800,000 new cases of BCC each year. Living in areas close to the equator, at high altitudes, or in regions with a depleted ozone increases the risk of skin damage and BCC. Risk factors for developing BCC are being over age 40, freckled skin, eye colors other than brown, blonde or red hair, a family history of skin cancer, and having previous severe sunburns. About 30% of Caucasians develop BCC in their lifetime.

When testing for BCC, a doctor will remove a piece of skin to be examined. Treatments include cutting or killing affected skin cells, applying medicated creams, and light therapy. Mohs surgery is an effective surgery for skin cancer in which a small area of the skin is removed layer-by-layer and examined until a layer without cancer is found. For BCC that cannot be treated by surgery, radiation or chemotherapy may be used.

Routine skin examinations are important in order to detect BCC early. Early treatment reduces the chances of the cancer spreading to other areas, including other organs. Certain aggressive types of BCC may be lethal if undetected. Avoiding prolonged exposure to sunlight and wearing sunscreen can help prevent BCC. If you have been diagnosed with BCC, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Basal cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Basal cell carcinoma" returned 715 free, full-text research articles on human participants. First 3 results:

A rare development of basal cell carcinoma on trichoepithelioma in a chemical burn scar tissue: A case report.
 

Author(s): Seong Hwan Kim, Dong Wan Kim, Jae Ha Hwang, Kwang Seog Kim, Sam Yong Lee

Journal: Medicine (Baltimore). 2018 Sep;97(38):e12252.

 

Trichoepithelioma (TE) is a rare benign skin tumor that originates from the hair follicle epithelium. Although skin lesions arising from scar tissues are mostly malignant, the development of a benign tumor such as TE is a rare event.

Last Updated: 31 Dec 1969

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Secondary basal cell carcinoma of scalp after radiotherapy: A case report.
 

Author(s): Frank Chen, Sheau-Fang Yang, Chien-Hung Chen, Ann-Shung Lieu, Shih-Tsung Cheng, Ming-Yii Huang, Hsin-Hua Lee

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12170.

 

Radiotherapy (RT) is widely used for both malignant and benign tumors in order to reduce the risk of recurrence, to promote tumor control, and to improve survival. However, there have been studies reported that RT is also a risk factor of secondary cancer. Very few cases of secondary ...

Last Updated: 31 Dec 1969

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[Basal cell carcinoma: about a historical case].
 

Author(s): Mohamed El Amraoui, Mohammed Boui

Journal:

 

We here report the case of an 80 year old man, with clear phototype, villager, residing in one of the most isolated places in our kingdom, located at an altitude above 2400 metres. During humanitarian aid, he presented with ulcero-necrotic tumor infiltrating the nasal root and the ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Basal cell carcinoma" returned 71 free, full-text review articles on human participants. First 3 results:

Emerging trends in the treatment of advanced basal cell carcinoma.
 

Author(s): Michael R Migden, Anne Lynn S Chang, Luc Dirix, Alexander J Stratigos, John T Lear

Journal: Cancer Treat. Rev.. 2018 Mar;64():1-10.

 

Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic surgery, curettage and electrodessication, radiotherapy, and/or superficial field therapies (including ...

Last Updated: 31 Dec 1969

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[Nevoid basal-cell carcinoma syndrome (Gorlin Syndrome): report of two cases and review of the literature].
 

Author(s): María Del Carmen Castro-Mujica, Claudia Barletta-Carrillo, Julio A Poterico, Marisa Acosta, Jesús Valer, Miguel De La Cruz

Journal: Rev Peru Med Exp Salud Publica. ;34(4):744-750.

 

Gorlin syndrome (GS) is a genetic disorder with an autosomal dominant inheritance pattern, with complete penetrance and variable expressivity. GS is caused by germline mutations in the genes PTCH1 or SUFU, which are components of the Sonic hedgehog molecular pathway. GS is characterized ...

Last Updated: 31 Dec 1969

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Understanding the Molecular Genetics of Basal Cell Carcinoma.
 

Author(s): Cristina Pellegrini, Maria Giovanna Maturo, Lucia Di Nardo, Valeria Ciciarelli, Carlota Gutiérrez García-Rodrigo, Maria Concetta Fargnoli

Journal:

 

Basal cell carcinoma (BCC) is the most common human cancer and represents a growing public health care problem. Several tumor suppressor genes and proto-oncogenes have been implicated in BCC pathogenesis, including the key components of the Hedgehog pathway, 1 and , the 53 tumor suppressor, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Topical Itraconazole in the Treatment of Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 4 Sep 2018

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Confocal Microscopy Evaluation of Margin Clearance in Basal Cell Carcinomas in Mohs Surgery
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 21 Aug 2018

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A Study of IO103 in Montanide Adjuvant for Basal Cell Carcinoma
 

Status: Not yet recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 18 Oct 2018

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