Basal cell carcinoma

Common Name(s)

Basal cell carcinoma

Basal cell carcinoma (BCC) is a slow-growing skin cancer and the most common form of cancer in the United States. The cancer starts within the outermost layer of skin, typically in areas with prolonged exposure to ultraviolet radiation from sunlight or tanning beds. Signs of BCC include skin lesions that are different in appearance, color, size, or texture than the surrounding skin. The lesion may also be painful, swollen, itchy, or bleed. The most common location where BCC is found is on the head or neck.

In the United States, there are about 800,000 new cases of BCC each year. Living in areas close to the equator, at high altitudes, or in regions with a depleted ozone increases the risk of skin damage and BCC. Risk factors for developing BCC are being over age 40, freckled skin, eye colors other than brown, blonde or red hair, a family history of skin cancer, and having previous severe sunburns. About 30% of Caucasians develop BCC in their lifetime.

When testing for BCC, a doctor will remove a piece of skin to be examined. Treatments include cutting or killing affected skin cells, applying medicated creams, and light therapy. Mohs surgery is an effective surgery for skin cancer in which a small area of the skin is removed layer-by-layer and examined until a layer without cancer is found. For BCC that cannot be treated by surgery, radiation or chemotherapy may be used.

Routine skin examinations are important in order to detect BCC early. Early treatment reduces the chances of the cancer spreading to other areas, including other organs. Certain aggressive types of BCC may be lethal if undetected. Avoiding prolonged exposure to sunlight and wearing sunscreen can help prevent BCC. If you have been diagnosed with BCC, talk to your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Basal cell carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Basal cell carcinoma" returned 700 free, full-text research articles on human participants. First 3 results:

Solitary plantar basal cell carcinoma.
 

Author(s): Maura Simonetti Junqueira Bourroul, Ludmila Lopes Trindade, Vanessa Soares do Nascimento, Anderson da Costa Lino Costa, Ubirajara Honorato da Silva

Journal: An Bras Dermatol. 2018 Jun;93(3):419-421.

 

Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary ...

Last Updated: 31 Dec 1969

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Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases.
 

Author(s): Husein Husein-ElAhmed

Journal: An Bras Dermatol. 2018 Mar;93(2):229-232.

 

The behaviour of each basal cell carcinoma is known to be different according to the histological growth pattern. Among these aggressive lesions, sclerodermiform basal cell carcinomas are the most common type. This is a challenging-to-treat lesion due to its deep tissue invasion, ...

Last Updated: 31 Dec 1969

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Periungual basal cell carcinoma.
 

Author(s): Laura Loures Tavares, Juliana Corrêa Marques da Costa, Nathália Carvalho Delcourt, Nilton Carlos Dos Santos Rodrigues

Journal: An Bras Dermatol. ;93(1):114-115.

 

Periungual basal cell carcinoma is rare and needs to be differentiated from other common diseases that affect this region. Several factors are associated with the development of this tumor, and sun damage seems to play an important role in its pathogenesis. Dermoscopy of clinically ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Basal cell carcinoma" returned 70 free, full-text review articles on human participants. First 3 results:

Emerging trends in the treatment of advanced basal cell carcinoma.
 

Author(s): Michael R Migden, Anne Lynn S Chang, Luc Dirix, Alexander J Stratigos, John T Lear

Journal: Cancer Treat. Rev.. 2018 Mar;64():1-10.

 

Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic surgery, curettage and electrodessication, radiotherapy, and/or superficial field therapies (including ...

Last Updated: 31 Dec 1969

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Understanding the Molecular Genetics of Basal Cell Carcinoma.
 

Author(s): Cristina Pellegrini, Maria Giovanna Maturo, Lucia Di Nardo, Valeria Ciciarelli, Carlota Gutiérrez García-Rodrigo, Maria Concetta Fargnoli

Journal:

 

Basal cell carcinoma (BCC) is the most common human cancer and represents a growing public health care problem. Several tumor suppressor genes and proto-oncogenes have been implicated in BCC pathogenesis, including the key components of the Hedgehog pathway, 1 and , the 53 tumor suppressor, ...

Last Updated: 31 Dec 1969

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Development of a core outcome set for clinical trials in basal cell carcinoma: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.
 

Author(s): Daniel I Schlessinger, Sanjana Iyengar, Arianna F Yanes, Jake M Lazaroff, Victoria Godinez-Puig, Brian R Chen, Anastasia O Kurta, Jill K Henley, Sarah G Chiren, Karina C Furlan, Jochen Schmitt, Stefanie Deckert, Emily Poon, Joseph F Sobanko, Todd V Cartee, Murad Alam, Ian A Maher

Journal:

 

Basal cell carcinoma is the most common skin cancer worldwide. Treatment options include both surgical and topical modalities. Although risk of metastasis is low, basal cell carcinoma can be invasive and infiltrate important underlying structures such as bone or cartilage. While many ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Topical Itraconazole in the Treatment of Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 3 Oct 2017

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Confocal Microscopy Evaluation of Margin Clearance in Basal Cell Carcinomas in Mohs Surgery
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 26 Jul 2018

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RCM to Diagnose BCC - Reflectance Confocal Microscopy to Diagnose Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 26 Jul 2018

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