Basal cell carcinoma

Common Name(s)

Basal cell carcinoma

Basal cell carcinoma (BCC) is a slow-growing skin cancer and the most common form of cancer in the United States. The cancer starts within the outermost layer of skin, typically in areas with prolonged exposure to ultraviolet radiation from sunlight or tanning beds. Signs of BCC include skin lesions that are different in appearance, color, size, or texture than the surrounding skin. The lesion may also be painful, swollen, itchy, or bleed. The most common location where BCC is found is on the head or neck.

In the United States, there are about 800,000 new cases of BCC each year. Living in areas close to the equator, at high altitudes, or in regions with a depleted ozone increases the risk of skin damage and BCC. Risk factors for developing BCC are being over age 40, freckled skin, eye colors other than brown, blonde or red hair, a family history of skin cancer, and having previous severe sunburns. About 30% of Caucasians develop BCC in their lifetime.

When testing for BCC, a doctor will remove a piece of skin to be examined. Treatments include cutting or killing affected skin cells, applying medicated creams, and light therapy. Mohs surgery is an effective surgery for skin cancer in which a small area of the skin is removed layer-by-layer and examined until a layer without cancer is found. For BCC that cannot be treated by surgery, radiation or chemotherapy may be used.

Routine skin examinations are important in order to detect BCC early. Early treatment reduces the chances of the cancer spreading to other areas, including other organs. Certain aggressive types of BCC may be lethal if undetected. Avoiding prolonged exposure to sunlight and wearing sunscreen can help prevent BCC. If you have been diagnosed with BCC, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Basal cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Basal cell carcinoma" returned 688 free, full-text research articles on human participants. First 3 results:

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases.
 

Author(s): Husein Husein-ElAhmed

Journal: An Bras Dermatol. 2018 Mar;93(2):229-232.

 

The behaviour of each basal cell carcinoma is known to be different according to the histological growth pattern. Among these aggressive lesions, sclerodermiform basal cell carcinomas are the most common type. This is a challenging-to-treat lesion due to its deep tissue invasion, ...

Last Updated: 31 Dec 1969

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Periungual basal cell carcinoma.
 

Author(s): Laura Loures Tavares, Juliana Corrêa Marques da Costa, Nathália Carvalho Delcourt, Nilton Carlos Dos Santos Rodrigues

Journal: An Bras Dermatol. ;93(1):114-115.

 

Periungual basal cell carcinoma is rare and needs to be differentiated from other common diseases that affect this region. Several factors are associated with the development of this tumor, and sun damage seems to play an important role in its pathogenesis. Dermoscopy of clinically ...

Last Updated: 31 Dec 1969

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A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin.
 

Author(s): Akiko Kanzaki, Shin-Ichi Ansai, Takashi Ueno, Seiji Kawana, Akira Shimizu, Zenya Naito, Hidehisa Saeki

Journal: J Nippon Med Sch. 2017 ;84(6):286-290.

 

A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Histology of the biopsy ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Basal cell carcinoma" returned 68 free, full-text review articles on human participants. First 3 results:

Emerging trends in the treatment of advanced basal cell carcinoma.
 

Author(s): Michael R Migden, Anne Lynn S Chang, Luc Dirix, Alexander J Stratigos, John T Lear

Journal: Cancer Treat. Rev.. 2018 Mar;64():1-10.

 

Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic surgery, curettage and electrodessication, radiotherapy, and/or superficial field therapies (including ...

Last Updated: 31 Dec 1969

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Molecular basis of basal cell carcinoma.
 

Author(s): Erik Montagna, Otávio Sérgio Lopes

Journal: An Bras Dermatol. ;92(4):517-520.

 

Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, ...

Last Updated: 31 Dec 1969

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Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.
 

Author(s): Anshika Bakshi, Sandeep C Chaudhary, Mehtab Rana, Craig A Elmets, Mohammad Athar

Journal: Mol. Carcinog.. 2017 Dec;56(12):2543-2557.

 

Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling-related ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Topical Itraconazole in the Treatment of Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 3 Oct 2017

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RCM to Diagnose BCC - Reflectance Confocal Microscopy to Diagnose Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 29 Mar 2018

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Last Updated: 30 Apr 2018

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