Basal cell carcinoma

Common Name(s)

Basal cell carcinoma

Basal cell carcinoma (BCC) is a slow-growing skin cancer and the most common form of cancer in the United States. The cancer starts within the outermost layer of skin, typically in areas with prolonged exposure to ultraviolet radiation from sunlight or tanning beds. Signs of BCC include skin lesions that are different in appearance, color, size, or texture than the surrounding skin. The lesion may also be painful, swollen, itchy, or bleed. The most common location where BCC is found is on the head or neck.

In the United States, there are about 800,000 new cases of BCC each year. Living in areas close to the equator, at high altitudes, or in regions with a depleted ozone increases the risk of skin damage and BCC. Risk factors for developing BCC are being over age 40, freckled skin, eye colors other than brown, blonde or red hair, a family history of skin cancer, and having previous severe sunburns. About 30% of Caucasians develop BCC in their lifetime.

When testing for BCC, a doctor will remove a piece of skin to be examined. Treatments include cutting or killing affected skin cells, applying medicated creams, and light therapy. Mohs surgery is an effective surgery for skin cancer in which a small area of the skin is removed layer-by-layer and examined until a layer without cancer is found. For BCC that cannot be treated by surgery, radiation or chemotherapy may be used.

Routine skin examinations are important in order to detect BCC early. Early treatment reduces the chances of the cancer spreading to other areas, including other organs. Certain aggressive types of BCC may be lethal if undetected. Avoiding prolonged exposure to sunlight and wearing sunscreen can help prevent BCC. If you have been diagnosed with BCC, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Basal cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Basal cell carcinoma" returned 669 free, full-text research articles on human participants. First 3 results:

Investigation of P120catenin Expression in Human Basal Cell Carcinoma of the Skin.
 

Author(s): Vladimír Bartoš, Milada Kullová

Journal: Acta Medica (Hradec Kralove). ;60(1):32-36.

 

P120(ctn) is a specific membranous adhesion protein, that maintains the stability of intercellular junctions. An altered expression of p120(ctn), either reduced in the cell membrane or increase in the cytoplasm, plays a crucial role in carcinogenesis. No research has analysed the ...

Last Updated: 7 Jun 2017

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Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area.
 

Author(s): Gamze Ozturk Karabulut, Pelin Kaynak, Can Ozturker, Korhan Fazil, Osman Bulut Ocak, Muhittin Taskapılı

Journal: Indian J Ophthalmol. 2017 Jan;65(1):48-51.

 

Context (Background): Imiquimod (IMQ) 5% cream is an immunomodulatory and antitumorigenic agent, which was used as a topical treatment regimen, who had periocular basal cell carcinoma (BCC).

Last Updated: 16 Mar 2017

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Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis.
 

Author(s): Feng-Tao Shi, Mei Yu, David Zloty, Robert H Bell, Eddy Wang, Noushin Akhoundsadegh, Gigi Leung, Anne Haegert, Nicholas Carr, Jerry Shapiro, Kevin J McElwee

Journal: Mol Med Rep. 2017 Apr;15(4):1441-1454.

 

A subset of basal cell carcinomas (BCCs) are directly derived from hair follicles (HFs). In some respects, HFs can be defined as 'ordered' skin appendage growths, while BCCs can be regarded as 'disordered' skin appendage growths. The aim of the present study was to examine HFs and ...

Last Updated: 5 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Basal cell carcinoma" returned 65 free, full-text review articles on human participants. First 3 results:

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.
 

Author(s): Mihai Lupu, Constantin Caruntu, Mihaela Adriana Ghita, Vlad Voiculescu, Suzana Voiculescu, Adrian E Rosca, Ana Caruntu, Liliana Moraru, Iris Maria Popa, Bogdan Calenic, Maria Greabu, Daniela Elena Costea

Journal: Dis. Markers. 2016 ;2016():9831237.

 

Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development ...

Last Updated: 31 Aug 2016

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Role of Vismodegib in the Management of Advanced Periocular Basal Cell Carcinoma.
 

Author(s): Kyle F Cox, Curtis E Margo

Journal: Cancer Control. 2016 Apr;23(2):133-9.

 

Vismodegib is the first selective hedgehog pathway inhibitor approved to treat locally advanced and metastatic basal cell carcinoma (BCC). Limited information is available concerning its role in managing advanced BCC around the eye.

Last Updated: 25 May 2016

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Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome).
 

Author(s): Scott C Bresler, Bonnie L Padwa, Scott R Granter

Journal: Head Neck Pathol. 2016 Jun;10(2):119-24.

 

Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin syndrome), is a rare autosomal dominantly inherited disorder that is characterized by development of basal cell carcinomas from a young age. Other distinguishing clinical features are seen in a majority of ...

Last Updated: 21 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 1 Mar 2017

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Topical Itraconazole in the Treatment of Basal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 11 Sep 2017

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The Role of Melanocyte in Basal Cell Carcinoma
 

Status: Not yet recruiting

Condition Summary: Basal Cell Carcinoma

 

Last Updated: 13 Oct 2015

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