Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 741 free, full-text research articles on human participants. First 3 results:

Case report of recurrent atrial fibrillation induced by thyrotropin-secreting pituitary adenoma with Graves' disease.
 

Author(s): Jiaqi Li, Huiwen Tan, Juan Huang, Dan Luo, Ying Tang, Ruichao Yu, Hui Huang

Journal: Medicine (Baltimore). 2018 Jun;97(24):e11047.

 

Thyrotropin-secreting adenoma (TSHoma) is rare. Even though the thyrotoxicosis is mild in patients with TSHoma, it is still a rare cause of arrhythmia, ignore of mild disfunction of thyroid function of TSHoma can lead to the delayed diagnosis of pituitary tumor or leading to recurring ...

Last Updated: 31 Dec 1969

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Pattern of presentation of Graves' disease and response to radioiodine therapy in South African men.
 

Author(s): Yetunde Ajoke Onimode, David Magbagbeola Dairo, Annare Ellmann

Journal:

 

Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0.7 per 100, 000 has ...

Last Updated: 31 Dec 1969

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Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease.
 

Author(s): Yuki Mizuguchi, Satoshi Morimoto, Shihori Kimura, Noriyoshi Takano, Kaoru Yamashita, Yasufumi Seki, Kanako Bokuda, Midori Yatabe, Junichi Yatabe, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara

Journal:

 

Antithyroid drugs are generally selected as the first-line treatment for Graves' Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR] is a multi-functional protein ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 58 free, full-text review articles on human participants. First 3 results:

Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Danyal Imani, Ramazan Rezaei, Bahman Razi, Shahab Alizadeh, Mahdi Mahmoudi

Journal: Acta Med Iran. 2017 Nov;55(11):665-671.

 

Several studies have evaluated the association between interleukin-6 (IL-6) -174 G/C polymorphism and Graves' disease (GD); however, the results have been inconsistent. In the current study, a meta-analysis was performed to assess the association of IL6 -174 G/C polymorphism with ...

Last Updated: 31 Dec 1969

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Is Graves' disease a primary immunodeficiency? New immunological perspectives on an endocrine disease.
 

Author(s): Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher, Philipp Schuetz

Journal:

 

Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, ...

Last Updated: 31 Dec 1969

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Personalised immunomodulating treatments for Graves' disease: fact or fiction?
 

Author(s): Tristan Mirko Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Müller, Philipp Schütz

Journal:

 

Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

HIFU vs RAI in the Relapsed Graves' Disease
 

Status: Recruiting

Condition Summary: Graves Disease

 

Last Updated: 12 Jul 2017

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Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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K1-70 - A Study in Subjects With Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 16 May 2018

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