Becker muscular dystrophy

Common Name(s)

Becker muscular dystrophy

Becker muscular dystrophy (BMD) is a genetic disorder that causes progressive muscle weakness and decreased muscle tissue (atrophy). BMD is a milder form of Duchenne muscular dystrophy. It is seen mostly in males with symptoms typically beginning in the teenage years or later. Symptoms of the condition begin with muscle weakness in the lower body, usually in the legs and pelvis area. This weakness progresses, causing difficulty with walking, running, and jumping. Individuals with BMD may lose the ability to walk, but typically much later than individuals with Duchenne muscular dystrophy. Another symptom of BMD is weakness of the heart muscle (cardiomyopathy), which may cause shortness of breath, abnormal heartbeat (arrhythmia), and extreme tiredness (fatigue).

BMD, which is caused by mutations in the DMD gene, is inherited in an X-linked recessive pattern. Males have one copy of the DMD gene while females have two copies. Males who have a mutation in their only copy of the gene have the condition, while females with a mutation in one of their two copies typically do not.

In order to diagnose this condition, your child’s doctor will take a detailed medical history, perform a physical exam, and likely perform one of many possible tests, which can include collecting and examining a small piece of muscle tissue (muscle biopsy), measuring electrical activity in muscles (electromyography), measuring the amount of CK enzyme in blood, as well as monitoring the heart and lungs. DMD gene testing is typically needed to confirm the diagnosis. Treatment of BMD is geared towards managing symptoms in order to maximize quality of life. Medications may be prescribed to help with pain. Physical activity can help maintain strength. Physical therapy and orthopedic devices such as braces and wheelchairs may be helpful for self-care and independent movement. Talk with a doctor about the right treatment for you or your child.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Becker muscular dystrophy" for support, advocacy or research.

LGMD-diagnosis.org

LGMD-diagnosis.org is sponsored by a consortium of family foundations that each focus on a separate form of LGMD. By coming together and pooling resources, the consortium foundations are rapidly and efficiently diagnosing many patients. The consortium includes the Cecil B Day Family, Inc (LGMD2B), Coalition to Cure Calpain 3 (LGMD2A), Jain Foundation (LGMD2B), Kurt + Peter Foundation (LGMD2C), LGMD2D Foundation, LGMD2I Fund, and McColl-Lockwood Laboratory (LGMD2I).

Last Updated: 22 May 2015

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Neuromuscular Disease Association of China

There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve

Last Updated: 21 May 2010

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Parent Project Muscular Dystrophy

Parent Project Muscular Dystrophy’s mission is to end Duchenne. We accelerate research, raise our voices in Washington, demand optimal care for all young men, and educate the global community.

Last Updated: 15 Nov 2012

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Thisbe and Noah Scott Foundation, Inc.

It is the mission of the Thisbe and Noah Scott Foundation, Inc. to save lives by promoting research, awareness and support for children and families affected by pediatric neuromuscular diseases.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Becker muscular dystrophy" for support, advocacy or research.

LGMD-diagnosis.org

LGMD-diagnosis.org is sponsored by a consortium of family foundations that each focus on a separate form of LGMD. By coming together and pooling resources, the consortium foundations are rapidly and efficiently diagnosing many patients. The consortium includes the Cecil B Day Family, Inc (LGMD2B), Coalition to Cure Calpain 3 (LGMD2A), Jain Foundation (LGMD2B), Kurt + Peter Foundation (LGMD2C), LGMD2D Foundation, LGMD2I Fund, and McColl-Lockwood Laboratory (LGMD2I).

https://www.lgmd-diagnosis.org

Last Updated: 22 May 2015

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Neuromuscular Disease Association of China

There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve

http://www.mdachina.org

Last Updated: 21 May 2010

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Parent Project Muscular Dystrophy

Parent Project Muscular Dystrophy’s mission is to end Duchenne. We accelerate research, raise our voices in Washington, demand optimal care for all young men, and educate the global community.

http://www.parentprojectmd.org

Last Updated: 15 Nov 2012

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Thisbe and Noah Scott Foundation, Inc.

It is the mission of the Thisbe and Noah Scott Foundation, Inc. to save lives by promoting research, awareness and support for children and families affected by pediatric neuromuscular diseases.

http://www.thisbeandnoah.org/

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Becker muscular dystrophy" returned 130 free, full-text research articles on human participants. First 3 results:

A rare subclinical or mild type of Becker muscular dystrophy caused by a single exon 48 deletion of the dystrophin gene.
 

Author(s): Janusz G Zimowski, Jacek Pilch, Magdalena Pawelec, Joanna K Purzycka, Jolanta Kubalska, Karolina Ziora-Jakutowicz, Magdalena Dudzińska, Jacek Zaremba

Journal: J. Appl. Genet.. 2017 Aug;58(3):343-347.

 

In the material of 227 families with Becker muscular dystrophy (BMD), we found nine non-consanguineous families with 17 male individuals carrying a rare mutation-a single exon 48 deletion of the dystrophin gene-who were affected with a very mild or subclinical form of BMD. They were ...

Last Updated: 1 Mar 2017

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Repair of an inguinoscrotal hernia in a patient with Becker muscular dystrophy.
 

Author(s): F Tatulli, A Caraglia, A Delcuratolo, S Cassano, G S Chetta

Journal: G Chir. ;37(5):216-219.

 

Inguinal hernia repairs are routinely performed as outpatient procedures in most patients, whereas a few require admission due to clinical or social peculiarities. Muscular dystrophies are inherited disorders characterized by progressive muscle wasting and weakness. In case of surgery ...

Last Updated: 18 Jan 2017

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A case report: Becker muscular dystrophy presenting with epilepsy and dysgnosia induced by duplication mutation of Dystrophin gene.
 

Author(s): Jing Miao, Jia-Chun Feng, Dan Zhu, Xue-Fan Yu

Journal:

 

Becker muscular dystrophy (BMD), a genetic disorder of X-linked recessive inheritance, typically presents with gradually progressive muscle weakness. The condition is caused by mutations of Dystrophin gene located at Xp21.2. Epilepsy is an infrequent manifestation of BMD, while cases ...

Last Updated: 13 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Becker muscular dystrophy" returned 6 free, full-text review articles on human participants. First 3 results:

Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124).
 

Author(s): Richard S Finkel

Journal: J. Child Neurol.. 2010 Sep;25(9):1158-64.

 

Nucleotide changes within an exon can alter the trinucleotide normally encoding a particular amino acid, such that a new ''stop'' signal is transcribed into the mRNA open reading frame. This causes the ribosome to prematurely terminate its reading of the mRNA, leading to nonsense-mediated ...

Last Updated: 6 Sep 2010

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Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy.
 

Author(s): Rita Wen Kaspar, Hugh D Allen, Federica Montanaro

Journal: J Am Acad Nurse Pract. 2009 May;21(5):241-9.

 

To review the current understanding of the pathophysiology of dilated cardiomyopathy (DCM) in patients with Duchenne and Becker muscular dystrophies, assessment of cardiac dysfunction for these patients, and the recommended pharmacological treatment options and ongoing research directions.

Last Updated: 12 May 2009

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Cardiac involvement in Becker muscular dystrophy.
 

Author(s): Josef Finsterer, Claudia Stöllberger

Journal: Can J Cardiol. 2008 Oct;24(10):786-92.

 

The present review gives an overview of the clinical and subclinical manifestations of cardiac involvement (CI) in Becker muscular dystrophy (BMD), its pathophysiological background, diagnostic possibilities and therapeutic options for CI in BMD patients and carriers. CI may be subclinical ...

Last Updated: 8 Oct 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study)
 

Status: Recruiting

Condition Summary: Becker Muscular Dystrophy

 

Last Updated: 10 Mar 2017

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(-)- Epicatechin Becker Muscular Dystrophy
 

Status: Recruiting

Condition Summary: Becker Muscular Dystrophy

 

Last Updated: 28 Jul 2017

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Clinical Study to Evaluate the Efficacy and Safety of Givinostat in Ambulant Patients With Becker Muscular Dystrophy
 

Status: Not yet recruiting

Condition Summary: Becker Muscular Dystrophy

 

Last Updated: 28 Aug 2017

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