Blepharospasm

Common Name(s)

Blepharospasm, Benign Essential Blepharospasm (BEB)

Benign essential blepharospasm is a progressive neurological disorder characterized by involuntary muscle contractions and spasms of the eyelid muscles. It is a form of dystonia, a movement disorder in which muscle contractions cause sustained eyelid closure, twitching or repetitive movements. Benign essential blepharospasm occurs in both men and women, although it is especially common in middle-aged and elderly women. Most cases are treated with botulinum toxin injections. The exact cause of benign essential blepharospasm is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

Last Updated: 3 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

http://www.blepharospasm.org/

Last Updated: 3 Mar 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Blepharospasm" returned 94 free, full-text research articles on human participants. First 3 results:

Surgical approach to limiting skin contracture following protractor myectomy for essential blepharospasm.
 

Author(s): Jeremy Clark, John Randolph, Jason A Sokol, Nicholas A Moore, Hui Bae H Lee, William R Nunery

Journal:

 

To report our experience with protractor myectomy in patients with benign essential blepharospasm who did not respond to serial botulinum toxin injection, and to describe intra- and postoperative techniques that limited skin contracture while also providing excellent functional and cosmetic results.

Last Updated: 31 Dec 1969

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Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation.
 

Author(s): Nijee S Luthra, Kyle T Mitchell, Monica M Volz, Idit Tamir, Phillip A Starr, Jill L Ostrem

Journal:

 

Blepharospasm can be present as an isolated dystonia or in conjunction with other forms of cranial dystonia, causing significant disability.

Last Updated: 31 Dec 1969

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Nonmotor symptoms in primary adult-onset cervical dystonia and blepharospasm.
 

Author(s): Jing Yang, Na Shao, Wei Song, Qianqian Wei, Ruwei Ou, Ying Wu, Hui-Fang Shang

Journal:

 

The nature and frequency of nonmotor symptoms in primary adult-onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Blepharospasm" returned 8 free, full-text review articles on human participants. First 3 results:

Blepharospasm 40 years later.
 

Author(s): Giovanni Defazio, Mark Hallett, Hyder A Jinnah, Antonella Conte, Alfredo Berardelli

Journal: Mov. Disord.. 2017 04;32(4):498-509.

 

Forty years ago, C.D. Marsden proposed that blepharospasm should be considered a form of adult-onset focal dystonia. In the present paper, we provide a comprehensive overview of the findings regarding blepharospasm reported in the past 40 years. Although prolonged spasms of the orbicularis ...

Last Updated: 31 Dec 1969

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Secondary blepharospasm associated with structural lesions of the brain.
 

Author(s): M A Khooshnoodi, S A Factor, H A Jinnah

Journal: J. Neurol. Sci.. 2013 Aug;331(1-2):98-101.

 

Blepharospasm is a form of focal dystonia that manifests as repetitive involuntary closure of the eyes. The pathogenesis of blepharospasm and the neuroanatomic substrates involved are not fully understood. Dysfunction of the basal ganglia traditionally is presumed to be the main cause ...

Last Updated: 31 Dec 1969

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[Essential blepharospasm: literature review].
 

Author(s): André Gustavo Bombana Nicoletti, Lísia Aoki, Tatiana Rizkallah Nahas, Suzana Matayoshi

Journal: Arq Bras Oftalmol. ;73(5):469-73.

 

Essential blepharospasm is a focal distonia characterized by involuntary, spasmodic, bilateral contractions of eyelid protractors. This is a rare disease, which diagnosis is frequently late and symptoms may progress until functional blindness. In this article, we perform a review ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Photic Blink Reflex in People With Blepharospasm and Increased Blinking
 

Status: Recruiting

Condition Summary: Blepharospasm

 

Last Updated: 24 Apr 2018

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Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm
 

Status: Recruiting

Condition Summary: Blepharospasm

 

Last Updated: 26 Oct 2016

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Blepharospasm Tools
 

Status: Recruiting

Condition Summary: Blepharospasm; Dystonia; Other Eye and Face Disorders

 

Last Updated: 1 Aug 2017

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