Blepharospasm

Common Name(s)

Blepharospasm, Benign Essential Blepharospasm (BEB)

Benign essential blepharospasm is a progressive neurological disorder characterized by involuntary muscle contractions and spasms of the eyelid muscles. It is a form of dystonia, a movement disorder in which muscle contractions cause sustained eyelid closure, twitching or repetitive movements. Benign essential blepharospasm occurs in both men and women, although it is especially common in middle-aged and elderly women. Most cases are treated with botulinum toxin injections. The exact cause of benign essential blepharospasm is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

Last Updated: 3 Mar 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blepharospasm" for support, advocacy or research.

Benign Essential Blepharospasm Research Foundation, Inc.

The Mission of the Benign Essential Blepharospasm Research Foundation, Inc. is to fund and promote medical research in the search for the cause and cure of blepharospasm, Meige, and other related disorders of the facial musculature, to provide support, education and referrals to persons with these disorders, and to disseminate information and serve as an authoritative resource to the medical community and the general public.

http://www.blepharospasm.org/

Last Updated: 3 Mar 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Blepharospasm" returned 97 free, full-text research articles on human participants. First 3 results:

Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes.
 

Author(s): Huina Zhang, Hongjie Zhou, Tiepei Zhu, Juan Ye

Journal:

 

To investigate changes in corneal elevation, pachymetry, and keratometry in discriminating between normal and blepharospasm eyes, as measured by the Pentacam rotating Scheimpflug camera.

Last Updated: 31 Dec 1969

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Spinocerebellar Ataxia Type 31 with Blepharospasm.
 

Author(s): Sakiko Itaya, Zen Kobayashi, Kokoro Ozaki, Nozomu Sato, Yoshiyuki Numasawa, Kinya Ishikawa, Takanori Yokota, Hiroshi Matsuda, Shuzo Shintani

Journal: Intern. Med.. 2018 Jun;57(11):1651-1654.

 

A 58-year-old man consulted our hospital due to a 2-year history of dysarthria and a 1-month history of blepharospasm. In addition to the ataxic dysarthria and blepharospasm, a neurological examination demonstrated slight ataxia of the trunk and lower limbs. Brain MRI demonstrated ...

Last Updated: 31 Dec 1969

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Surgical approach to limiting skin contracture following protractor myectomy for essential blepharospasm.
 

Author(s): Jeremy Clark, John Randolph, Jason A Sokol, Nicholas A Moore, Hui Bae H Lee, William R Nunery

Journal:

 

To report our experience with protractor myectomy in patients with benign essential blepharospasm who did not respond to serial botulinum toxin injection, and to describe intra- and postoperative techniques that limited skin contracture while also providing excellent functional and cosmetic results.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Blepharospasm" returned 8 free, full-text review articles on human participants. First 3 results:

Blepharospasm 40 years later.
 

Author(s): Giovanni Defazio, Mark Hallett, Hyder A Jinnah, Antonella Conte, Alfredo Berardelli

Journal: Mov. Disord.. 2017 04;32(4):498-509.

 

Forty years ago, C.D. Marsden proposed that blepharospasm should be considered a form of adult-onset focal dystonia. In the present paper, we provide a comprehensive overview of the findings regarding blepharospasm reported in the past 40 years. Although prolonged spasms of the orbicularis ...

Last Updated: 31 Dec 1969

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Secondary blepharospasm associated with structural lesions of the brain.
 

Author(s): M A Khooshnoodi, S A Factor, H A Jinnah

Journal: J. Neurol. Sci.. 2013 Aug;331(1-2):98-101.

 

Blepharospasm is a form of focal dystonia that manifests as repetitive involuntary closure of the eyes. The pathogenesis of blepharospasm and the neuroanatomic substrates involved are not fully understood. Dysfunction of the basal ganglia traditionally is presumed to be the main cause ...

Last Updated: 31 Dec 1969

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[Essential blepharospasm: literature review].
 

Author(s): André Gustavo Bombana Nicoletti, Lísia Aoki, Tatiana Rizkallah Nahas, Suzana Matayoshi

Journal: Arq Bras Oftalmol. ;73(5):469-73.

 

Essential blepharospasm is a focal distonia characterized by involuntary, spasmodic, bilateral contractions of eyelid protractors. This is a rare disease, which diagnosis is frequently late and symptoms may progress until functional blindness. In this article, we perform a review ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Photic Blink Reflex in People With Blepharospasm and Increased Blinking
 

Status: Recruiting

Condition Summary: Blepharospasm

 

Last Updated: 26 Jun 2018

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Blepharospasm Tools
 

Status: Recruiting

Condition Summary: Blepharospasm; Dystonia; Other Eye and Face Disorders

 

Last Updated: 7 Aug 2018

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HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions
 

Status: Recruiting

Condition Summary: Epilepsy; Neuropathy; Psychiatric Illness; Blepharospasm

 

Last Updated: 2 Sep 2018

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