Berger Disease

Common Name(s)

Berger Disease

Berger disease (frequently called IgA nephropathy) is a kidney disorder that occurs when IgA, a protein that helps the body fight infections, settles in the kidneys. The cause of this condition is unknown. After many years, deposits of IgA may cause the kidneys to leak blood and sometimes protein in the urine. In the early stages, Berger disease has no symptoms. The first sign of this condition may be blood in the urine. After 10 to 20 years with Berger disease, the kidneys may show signs of damage. Treatment focuses on slowing the disease and preventing complications.

Berger disease can occur at any age, even in childhood. About 25 percent of adults and 5 to 10 percent of children with Berger disease develop total kidney failure. Total kidney failure means the kidney damage is permanent and dialysis or a kidney transplant is required.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Berger Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Berger Disease" returned 1 free, full-text research articles on human participants. First 3 results:

Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits.
 

Author(s): Elie Haddad, Ivan C Moura, Michelle Arcos-Fajardo, Marie-Alice Macher, Veronique Baudouin, Corinne Alberti, Chantal Loirat, Renato C Monteiro, Michel Peuchmaur

Journal: J. Am. Soc. Nephrol.. 2003 Feb;14(2):327-37.

 

ABSTRACT. IgA nephropathy (IgA-N) that comprises Berger disease and Henoch-Schönlein Purpura (HSP) nephritis is defined by mesangial IgA deposits. Recently, this group has characterized a new receptor for IgA, the transferrin receptor (CD71), expressed on mesangial cells. To assess ...

Last Updated: 22 Jan 2003

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Berger Disease" returned 1 free, full-text review articles on human participants. First 3 results:

[Berger disease: therapeutic algorithm proposal and chronic renal failure predictive factors].
 

Author(s): Pedro Pessegueiro, Conceição Barata, José Correia

Journal: Acta Med Port. ;16(4):261-6.

 

Berger disease is described as a glomerulonephritis by anti-IgA and anti-IgG immune complexes and it has become the most common form of glomerulonephritis, affecting up to 1,3% of the population, most often affecting young adult males. Berger disease etiopathogenesis is still unknown, ...

Last Updated: 9 Jan 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

IgA Nephropathy Registration Initiative of High Quality (INSIGHT)
 

Status: Recruiting

Condition Summary: IgA Nephropathy

 

Last Updated: 22 Dec 2016

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Rituximab in Recurrent IgA Nephropathy
 

Status: Recruiting

Condition Summary: Recurrent IgA Nephropathy

 

Last Updated: 7 Oct 2015

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Efficacy and Safety of Atacicept in IgA Nephropathy
 

Status: Recruiting

Condition Summary: IgA Nephropathy

 

Last Updated: 15 Aug 2017

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