Berylliosis

Common Name(s)

Berylliosis

Berylliosis, also known as chronic beryllium disease (CBD), is a rare disease that affects a person’s lungs. Berylliosis is a chronic allergic-type response causing lung disease which occurs when people breathe in beryllium (a chemical). Though people do not intentionally inhale or breathe in the beryllium, factories that use beryllium release it into the air, People in cities surrounding the factories may be affected by berylliosis. The most common factories that use beryllium are ones associated with aerospace and those making fluorescent light bulbs. Symptoms of berylliosis include coughing, shortness of breath, chest pain, and a fever. Talk with your doctor to find the best treatment if you or a loved one has been diagnosed with berylliosis.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Berylliosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Berylliosis" returned 12 free, full-text research articles on human participants. First 3 results:

Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells.
 

Author(s): Massimo Amicosante, Floriana Berretta, Raed Dweik, Cesare Saltini

Journal: Immunology. 2009 Sep;128(1 Suppl):e462-70.

 

Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position beta69 (HLA-DPGlu69). This study was designed ...

Last Updated: 10 Sep 2009

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Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69.
 

Author(s): Massimo Amicosante, Floriana Berretta, Milton Rossman, Richard H Butler, Paola Rogliani, Ella van den Berg-Loonen, Cesare Saltini

Journal:

 

Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP beta-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found ...

Last Updated: 5 Sep 2005

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Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis.
 

Author(s): Yuan K Chou, David M Edwards, Andrew D Weinberg, Arthur A Vandenbark, Brian L Kotzin, Andrew P Fontenot, Gregory G Burrows

Journal: J. Immunol.. 2005 Apr;174(7):4316-24.

 

CD4(+) T cells play a key role in granulomatous inflammation in the lung of patients with chronic beryllium disease. The goal of this study was to characterize activation pathways of beryllium-responsive bronchoalveolar lavage (BAL) CD4(+) T cells from chronic beryllium disease patients ...

Last Updated: 21 Mar 2005

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Berylliosis" returned 1 free, full-text review articles on human participants. First 3 results:

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model.
 

Author(s): C Saltini, M Amicosante, A Franchi, G Lombardi, L Richeldi

Journal: Eur. Respir. J.. 1998 Dec;12(6):1463-75.

 

The role of genetic factors has been hypothesized in the pathogenesis of a number of chronic inflammatory lung diseases. The genes of the major histocompatibility complex (MHC) locus on human chromosome 6 have been identified as important determinants in diseases caused both by inorganic ...

Last Updated: 4 Mar 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)
 

Status: Recruiting

Condition Summary: Chronic Beryllium Disease (CBD); Beryllium Sensitization (BeS)

 

Last Updated: 20 Sep 2016

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Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD)
 

Status: Recruiting

Condition Summary: Chronic Beryllium Disease

 

Last Updated: 20 Sep 2016

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