Neurofibromatosis type 2

Common Name(s)

Neurofibromatosis type 2, Neurofibromatosis 2 (NF2), Bilateral Acoustic Neurofibromatosis, BANF Acoustic Neurinoma

Neurofibromatosis Type 2 (NF2) is a genetic condition that causes the development of non-cancerous (benign) tumors along the nerves in the body. NF2 is one type of neurofibromatosis, which is a group of genetic conditions that cause abnormal cell growth in nerve tissues throughout the body. Tumors in NF2 usually develop on the nerves that send messages from the inner ears to the brain (vestibular schwannomas or acoustic neuromas), but tumors can also develop in other nerves in the body. Symptoms of inner ear tumors in NF2 usually include trouble with balance, dizziness, headache, facial weakness, numbness, pain, ringing in ears (tinnitus), and hearing loss. Other symptoms may develop if tumors occur in other areas of the body and can include abnormal vision, weakness in the arms or legs, and fluid buildup in the brain.

NF2 is caused by a change (mutation) in the NF2 gene. This gene acts as a tumor suppressor for nerve cells, which means it helps control nerve cell growth and division. A mutation in the NF2 gene leads to uncontrolled nerve cell growth, which causes tumor development in nerve tissue throughout the body. NF2 is inherited in an autosomal dominant way, which means a mutation in one of two copies of the gene a person has is enough to cause the condition.

There are clinical criteria that doctors use to diagnose NF2. The condition is usually diagnosed by a doctor who is familiar with genetic conditions (geneticist). Genetic testing is used to confirm the clinical diagnosis. Although NF2 does not have a cure, management of many of the symptoms is possible. Treatment usually involves surgery to remove tumors in the ear as well as support for hearing loss. If your child has been diagnosed with NF2, talk with their doctor to determine a treatment plan. More information and support is available through NF support groups.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibromatosis type 2" for support, advocacy or research.

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Children's Tumor Foundation, Inc.

Funds research, patient support and public awareness of the neurofibromatoses (NF1, NF2, and Schwannomatosis) - genetic disorders that cause random tumor growth throughout the body.

Last Updated: 14 Jan 2013

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Littlest Tumor Foundation

The Littlest Tumor Foundation is a nonprofit organization dedicated to finding preventative therapies and threatment for tumor growth in children and providing wellness scholarships to families dealing with Neurofibromatosis (NF). Our mission is to increase understanding of NF, to empower families dealing with the disorder, and to continue research of preventative therapies.

Last Updated: 4 Feb 2013

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Neurofibromatosis Mid-Atlantic

Neurofibromatosis Mid-Atlantic is a non profit organization dedicated to helping people with Neurofibromatosis and their loved ones make sense of the complex medical disorder. We provide reliable, complete, and up to date information about Neurofibromatosis. We provide education, support, and community. There is no charge for our services.

Last Updated: 22 Dec 2012

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Neurofibromatosis, Inc., Northeast

Our mission is to find treatments and the cure for neurofibromatosis by promoting scientific research, creating awareness, and providing hope and support to those who are affected by NF.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibromatosis type 2" for support, advocacy or research.

Logo
Children's Tumor Foundation, Inc.

Funds research, patient support and public awareness of the neurofibromatoses (NF1, NF2, and Schwannomatosis) - genetic disorders that cause random tumor growth throughout the body.

https://www.ctf.org

Last Updated: 14 Jan 2013

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Littlest Tumor Foundation

The Littlest Tumor Foundation is a nonprofit organization dedicated to finding preventative therapies and threatment for tumor growth in children and providing wellness scholarships to families dealing with Neurofibromatosis (NF). Our mission is to increase understanding of NF, to empower families dealing with the disorder, and to continue research of preventative therapies.

http://www.littlesttumor.org

Last Updated: 4 Feb 2013

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Neurofibromatosis Mid-Atlantic

Neurofibromatosis Mid-Atlantic is a non profit organization dedicated to helping people with Neurofibromatosis and their loved ones make sense of the complex medical disorder. We provide reliable, complete, and up to date information about Neurofibromatosis. We provide education, support, and community. There is no charge for our services.

http://www.nfmidatlantic.org

Last Updated: 22 Dec 2012

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Neurofibromatosis, Inc., Northeast

Our mission is to find treatments and the cure for neurofibromatosis by promoting scientific research, creating awareness, and providing hope and support to those who are affected by NF.

http://www.nfincne.org

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neurofibromatosis type 2" returned 113 free, full-text research articles on human participants. First 3 results:

Population Characteristics and Progressive Disability in Neurofibromatosis Type 2.
 

Author(s): Kensho Iwatate, Takeshi Yokoo, Eriko Iwatate, Masahiro Ichikawa, Taku Sato, Masazumi Fujii, Jun Sakuma, Kiyoshi Saito

Journal: World Neurosurg. 2017 Oct;106():653-660.

 

To characterize the clinical features of patients with neurofibromatosis type 2 (NF2) and determine prognostic risk factors for progressive disabilities.

Last Updated: 31 Dec 1969

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The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis.
 

Author(s): Jaishri O Blakeley, Annette Bakker, Anne Barker, Wade Clapp, Rosalie Ferner, Michael J Fisher, Marco Giovannini, David H Gutmann, Matthias A Karajannis, Joseph L Kissil, Eric Legius, Alison C Lloyd, Roger J Packer, Vijaya Ramesh, Vincent M Riccardi, David A Stevenson, Nicole J Ullrich, Meena Upadhyaya, Anat Stemmer-Rachamimov

Journal: Am. J. Med. Genet. A. 2017 Jun;173(6):1714-1721.

 

The Annual Children's Tumor Foundation International Neurofibromatosis Meeting is the premier venue for connecting discovery, translational and clinical scientists who are focused on neurofibromatosis types 1 and 2 (NF1 and NF2) and schwannomatosis (SWN). The meeting also features ...

Last Updated: 31 Dec 1969

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First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation.
 

Author(s): Ramita Dewan, Alexander Pemov, Amalia S Dutra, Evgenia D Pak, Nancy A Edwards, Abhik Ray-Chaudhury, Nancy F Hansen, Settara C Chandrasekharappa, James C Mullikin, Ashok R Asthagiri, , John D Heiss, Douglas R Stewart, Anand V Germanwala

Journal:

 

Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. Currently, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neurofibromatosis type 2" returned 16 free, full-text review articles on human participants. First 3 results:

Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies.
 

Author(s): M Ruggieri, A D Praticò, A Serra, L Maiolino, S Cocuzza, P Di Mauro, L Licciardello, P Milone, G Privitera, G Belfiore, M Di Pietro, F Di Raimondo, A Romano, A Chiarenza, M Muglia, A Polizzi, D G Evans

Journal: Acta Otorhinolaryngol Ital. 2016 Oct;36(5):345-367.

 

Neurofibromatosis type 2 [NF2; MIM # 101000] is an autosomal dominant disorder characterised by the occurrence of vestibular schwannomas (VSs), schwannomas of other cranial, spinal and cutaneous nerves, cranial and spinal meningiomas and/or other central nervous system (CNS) tumours ...

Last Updated: 31 Dec 1969

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Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis.
 

Author(s): Jaishri O Blakeley, Scott R Plotkin

Journal: Neuro-oncology. 2016 05;18(5):624-38.

 

Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN) are tumor-suppressor syndromes. Each syndrome is an orphan disease; however, the tumors that arise within them represent the most common tumors of the nervous system worldwide. Systematic investigation ...

Last Updated: 31 Dec 1969

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Targeted therapy for hereditary cancer syndromes: neurofibromatosis type 1, neurofibromatosis type 2, and Gorlin syndrome.
 

Author(s): Rishi Agarwal, Sarah Liebe, Michelle L Turski, Smruti J Vidwans, Filip Janku, Ignacio Garrido-Laguna, Javier Munoz, Richard Schwab, Jordi Rodon, Razelle Kurzrock, Vivek Subbiah,

Journal: Discov Med. 2014 Dec;18(101):323-30.

 

Hereditary cancer syndromes are well known in the oncology community, typically affecting children, adolescents, and young adults and thereby resulting in great cumulative morbidity and mortality. These syndromes often lag behind their de novo counterparts in the development of approved ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors
 

Status: Recruiting

Condition Summary: Vestibular Schwannoma; Neurofibromatosis Type 2

 

Last Updated: 7 Feb 2017

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Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 2; Vestibular Schwannomas

 

Last Updated: 14 Jul 2017

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WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data
 

Status: Not yet recruiting

Condition Summary: Neurofibromatosis Type 2; Vestibular Schwannoma; Acoustic Neuroma

 

Last Updated: 4 Jul 2017

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