Biliary Tract Cancer

Common Name(s)

Biliary Tract Cancer

Bile Tract Cancer is a rare digestive cancer characterized by abnormal cell growth in the bile ducts and gallbladder. Individuals with this disorder may grow harmful tumors that can spread to the rest of the body if not diagnosed early. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors are usually able to diagnose this defect early in the abnormal growth process, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. For prevention measures, digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system. If an individual's cancer has progressed, doctors may suggest chemotherapy to combat cancer symptoms.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Tract Cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Tract Cancer" returned 162 free, full-text research articles on human participants. First 3 results:

Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients.
 

Author(s): Jinwoo Kang, Sang Hyub Lee, Jun Hyuk Son, Jae Woo Lee, Young Hoon Choi, Jin Ho Choi, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim

Journal:

 

The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary ...

Last Updated: 31 Dec 1969

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Human epidermal growth factor receptor 2, epidermal growth factor receptor, and c-MET overexpression and survival in biliary tract cancer: A meta-analysis.
 

Author(s): Wei Zhou, Congqing Jiang, Nan Zhan, Xiaoguang Lv, Lifang Fan, Maskey Ninu

Journal: J Cancer Res Ther. 2018 ;14(Supplement):S28-S35.

 

Tyrosine kinase growth factor receptors (TKGFRs) play an important role in the progression of cancer. A variety of studies have investigated the clinicopathologic correlation of these receptors and their influences on patient survival in different types of cancer. As the members of ...

Last Updated: 31 Dec 1969

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Effect of midkine on gemcitabine resistance in biliary tract cancer.
 

Author(s): Yongliang Lu, Bing Yan, Huihui Guo, Li Qiu, Xinrong Sun, Xiang Wang, Qian Shi, Ying Bao

Journal: Int. J. Mol. Med.. 2018 Apr;41(4):2003-2011.

 

Gemcitabine‑based chemotherapy is one of the most effective and commonly used chemotherapeutic regimens for biliary tract cancer (BTC). However, development of resistance to this drug limits its efficacy. The present study aimed to explore the effects of midkine (MDK) on the resistance ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Tract Cancer" returned 18 free, full-text review articles on human participants. First 3 results:

Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer.
 

Author(s): Hayato Nakagawa, Yuki Hayata, Tomoharu Yamada, Satoshi Kawamura, Nobumi Suzuki, Kazuhiko Koike

Journal:

 

The identification of the cellular origin of cancer is important for our understanding of the mechanisms regulating carcinogenesis, thus the cellular origin of cholangiocarcinoma (CCA) is a current topic of interest. Although CCA has been considered to originate from biliary epithelial ...

Last Updated: 31 Dec 1969

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Emerging molecular target antagonists for the treatment of biliary tract cancer.
 

Author(s): Pasquale Lombardi, Donatella Marino, Elisabetta Fenocchio, Giovanna ChilĂ , Massimo Aglietta, Francesco Leone

Journal: Expert Opin Emerg Drugs. 2018 03;23(1):63-75.

 

Biliary tract cancers (BTCs) are a heterogeneous group of cancers, characterized by low incidence but poor prognosis. Even after complete surgical resection for early stage, relapse is frequent and the lack of effective treatments contributes to the dismal prognosis. To date, the ...

Last Updated: 31 Dec 1969

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Biliary tract cancer stem cells - translational options and challenges.
 

Author(s): Christian Mayr, Matthias Ocker, Markus Ritter, Martin Pichler, Daniel Neureiter, Tobias Kiesslich

Journal: World J. Gastroenterol.. 2017 Apr;23(14):2470-2482.

 

Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers
 

Status: Recruiting

Condition Summary: Biliary Tract Cancer

 

Last Updated: 8 May 2017

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Molecular Profiling of Advanced Biliary Tract Cancers
 

Status: Not yet recruiting

Condition Summary: Biliary Tract Cancer

 

Last Updated: 25 Jan 2018

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Last Updated: 12 Sep 2018

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