Avian influenza

Common Name(s)

Avian influenza, Avian flu, Bird flu

Bird flu or avian influenza is an infection caused by different strains of avian influenza A virus. This virus infects wild water birds, but sometimes is passed to farm birds such as chicken, turkeys or ducks. The virus makes the farm birds very sick and many die. Sometimes the virus changes or mutates and spreads to people. The most common strains seen in humans include H5N1 and H7N9. H5N1 can cause serious illness and has a high death rate among humans. The virus strains are present worldwide but are more common in Asia, Europe, the Pacific, Near East and Africa. Only about 700 people have had the bird flu caused by H5N1. There have been no reported cases of the virus causing illness in people in the United States. The first reported case of a human infected by H5N1 was reported in 2014 in Canada.

Infections are caused by contact with sick or dead poultry infected with the virus. Infections do not normally spread between people, but there are a few cases where it has happened. Medical scientists worry that during an outbreak of bird flu, the virus may change or mutate so that it can be passed from human to human. This will cause the bird flu to spread much more rapidly over much larger areas.

Symptoms of bird flu in humans depends on which strain caused the infection. Some only cause mild illness while other strains like H5N1 can be very serious. In general symptoms may include fever, cough, sore throat, muscle aches, abdominal pain, diarrhea, pneumonia, and difficulty breathing. Diagnosis requires special lab tests. The best prevention is to avoid contact with sick or dead birds especially in areas with a known outbreak. Poultry and eggs should be properly cooked before eating. Treatment may include antiviral medications and supportive therapy. If you work with farm birds or come into contact with dead birds and develop flu symptoms, talk with your doctor about the most current testing and treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Avian influenza" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Avian influenza" returned 980 free, full-text research articles on human participants. First 3 results:

Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.
 

Author(s): Suli Liu, Wenfei Zhu, Zhaomin Feng, Rongbao Gao, Junfeng Guo, Xiyan Li, Jia Liu, Dayan Wang, Yuelong Shu

Journal:

 

Eurasian avian-like H1N1 (EA H1N1) swine influenza viruses (SIVs) have become predominant in pig populations in China and have recently been reported to have the most potential to raise the next pandemic in humans. The mutation D701N in the PB2 protein, which accounts for 31% of H1N1 ...

Last Updated: 31 Dec 1969

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A Combined NMR-Computational Study of the Interaction between Influenza Virus Hemagglutinin and Sialic Derivatives from Human and Avian Receptors on the Surface of Transfected Cells.
 

Author(s): Francesca Vasile, Maddalena Panigada, Antonio Siccardi, Donatella Potenza, Guido Tiana

Journal:

 

The development of small-molecule inhibitors of influenza virus Hemagglutinin could be relevant to the opposition of the diffusion of new pandemic viruses. In this work, we made use of Nuclear Magnetic Resonance (NMR) spectroscopy to study the interaction between two derivatives of ...

Last Updated: 31 Dec 1969

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Critical Role of HAX-1 in Promoting Avian Influenza Virus Replication in Lung Epithelial Cells.
 

Author(s): Xue Li, Bingqian Qu, Ganlin He, Carol J Cardona, Yongchun Song, Zheng Xing

Journal:

 

The PB1-F2 protein of influenza A virus has been considered a virulence factor, but its function in inducing apoptosis may be of disadvantage to viral replication. Host mechanisms to regulate PB1-F2-induced apoptosis remain unknown. We generated a PB1-F2-deficient avian influenza ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Avian influenza" returned 87 free, full-text review articles on human participants. First 3 results:

Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts.
 

Author(s): Khristine Kaith S Lloren, Taehyung Lee, Jin Jung Kwon, Min-Suk Song

Journal:

 

In the last decade, a wide range of avian influenza viruses (AIVs) have infected various mammalian hosts and continuously threaten both human and animal health. It is a result of overcoming the inter-species barrier which is mostly associated with gene reassortment and accumulation ...

Last Updated: 31 Dec 1969

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Current situation of H9N2 subtype avian influenza in China.
 

Author(s): Min Gu, Lijun Xu, Xiaoquan Wang, Xiufan Liu

Journal:

 

In China, H9N2 subtype avian influenza outbreak is firstly reported in Guangdong province in 1992. Subsequently, the disease spreads into vast majority regions nationwide and has currently become endemic there. Over vicennial genetic evolution, the viral pathogenicity and transmissibility ...

Last Updated: 31 Dec 1969

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A Systematic Review and Meta-Analysis of Practices Exposing Humans to Avian Influenza Viruses, Their Prevalence, and Rationale.
 

Author(s): Guillaume Fournié, Erling Høg, Tony Barnett, Dirk U Pfeiffer, Punam Mangtani

Journal: Am. J. Trop. Med. Hyg.. 2017 Aug;97(2):376-388.

 

Almost all human infections by avian influenza viruses (AIVs) are transmitted from poultry. A systematic review was conducted to identify practices associated with human infections, their prevalence, and rationale. Observational studies were identified through database searches. Meta-analysis ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical Trail Of An Adjuvanted Inactivated H7N9 Influenza Vaccine
 

Status: Recruiting

Condition Summary: H7N9 Influenza

 

Last Updated: 18 Apr 2018

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Sanofi 2017 H7N9 With/Without AS03 in Adults/Elderly
 

Status: Recruiting

Condition Summary: Avian Influenza; Influenza Immunisation

 

Last Updated: 13 Jul 2018

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Safety and Immunogenicity of Inactivated Influenza A/H5N1 Vaccine Administered With or Without Topical Aldara
 

Status: Recruiting

Condition Summary: Avian Influenza; Influenza Immunisation

 

Last Updated: 16 Aug 2018

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