Bowen's disease

Common Name(s)

Bowen's disease, Squamous cell carcinoma in situ

Bowen’s disease is a curable abnormal tumor growth of the skin and is considered to be an early stage of squamous cell carcinoma (cancer affecting epithelial cells, the top layer of your skin). Symptoms include a growing red, scaly patch with an irregular border. The red patches may be itchy and occasionally may be sore and bleed. Sometimes the red area may be raised. While the patches can occur anywhere on the body, they most commonly show up on the lower leg and rarely arise on your palms or soles. Bowen’s disease may be caused by sun damage, arsenic exposure, chronic skin injuries, suppressed immune systems (such as AIDS or due to medications after an organ transplant), viral infections (HPV), and other skin disorders. Bowen's disease is more common in women than men, and usually affects older people in their 70s-80s. It tends to be seen on people who have had lots of sun exposure (one of the main causes), especially those with fair skin.

Diagnosis is usually made by a skin sample (biopsy) taken by a doctor. Treatment includes local chemotherapy, photodynamic treatment (using non-toxic light), and freezing the growth. Since these growths have not yet reached the deeper skin layers, Bowen's disease has a better prognosis and is more easily cured than more invasive forms of skin cancer. Please see your doctor or a dermatologist, if you are experiencing any of these symptoms for early diagnosis. If you or a family member has been diagnosed with Bowen’s disease, talk with your doctor or dermatologist about current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Bowen's disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bowen's disease" returned 73 free, full-text research articles on human participants. First 3 results:

Collision tumor: pigmented Bowen's disease and seborrheic keratosis.
 

Author(s): Karen de Almeida Pinto Fernandes, Diana Carolina Salamanca Martinez, Aretha Brito Nobre, Gabriella Campos-do-Carmo

Journal: An Bras Dermatol. ;93(5):737-739.

 

Bowen's disease is a type of squamous cell carcinoma in situ of the skin. The pigmented form is rare and represents less than 2% of cases. We report a case of a 74-year-old black man with a blackened and asymptomatic leg injury for about 6 months. Clinically, and under dermatoscopy, ...

Last Updated: 31 Dec 1969

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Bowen's Disease Associated With Two Human Papilloma Virus Types.
 

Author(s): Hojat Eftekhari, Kaveh Gharaei Nejad, Seyyede Zeinab Azimi, Rana Rafiei, Alireza Mesbah

Journal: Acta Med Iran. 2017 Sep;55(9):594-596.

 

Bowen's disease (BD) is an epidermal in-situ squamous cell carcinoma (SCC). Most Human Papilloma Viruses (HPV)-positive lesions in Bowen's disease are localized to the genital region or distal extremities (periungual sites) in which HPV type-16 is frequently detected. Patient was ...

Last Updated: 31 Dec 1969

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Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand.
 

Author(s): Rute Facchini Lellis, John Verrinder Veasey, Renata Diniz Jacques Gonçalves

Journal: An Bras Dermatol. ;92(5):686-688.

 

Bowen's disease is an in situ squamous cell carcinoma of the skin with only 2% of pigmented cases reported. It is clinically characterized by papules and plaques of blackened surface that may be caused either by sun damage - usually in photoexposed areas in elderly individuals - or ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bowen's disease" returned 2 free, full-text review articles on human participants. First 3 results:

Clinical, histological and therapeutic features of Bowen's disease.
 

Author(s): Tiberiu Paul Neagu, Mirela Ţigliş, Delia Botezatu, Valentin Enache, Claudia Oana Cobilinschi, Mureş Sebastian Vâlcea-Precup, Ioana Marina GrinŢescu

Journal: Rom J Morphol Embryol. 2017 ;58(1):33-40.

 

Squamous cell carcinoma (SCC) in situ or Bowen's disease (BD) is a slowly progressive malignancy. However, cases of regression have been reported. Recent reviews cover only certain aspects of this disease; therefore, this paper's aim is to cover all the relevant aspects for medical ...

Last Updated: 31 Dec 1969

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Bowen's disease.
 

Author(s): M M Lee, M M Wick

Journal: CA Cancer J Clin. ;40(4):237-42.

 

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Aug 2018

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