Brain Stem Cancer

Common Name(s)

Brain Stem Cancer

Brain Stem Cancer is a rare form of cancer characterized by abnormal cell growth in the brain stem. Individuals with this disorder may grow harmful tumors in the brain that can impair brain function and spread to the rest of the body if not diagnosed and treated early. The brain stem is important for maintaining eye movements, muscle movements, and motor coordination. Brain stem cancer can thus cause individuals to be less capable of performing important movements, like walking and running. Some individuals may loss their ability to move certain parts of their body (paralysis). Without early diagnosis and treatment, prognosis for this condition can be severe. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. If an individual's cancer has progressed, doctors may suggest chemotherapy or surgery to combat cancer symptoms.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brain Stem Cancer" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brain Stem Cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brain Stem Cancer" returned 25 free, full-text research articles on human participants. First 3 results:

Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation.
 

Author(s): Lei Zhao, Yan Shen, Jin-Dong Guo, Heng-Le Gu, Wen Yu, Jia-Ming Wang, Chang-Xing Lv, Jun Liu, Xu-Wei Cai, Xiao-Long Fu

Journal:

 

This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC).

Last Updated: 31 Dec 1969

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Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.
 

Author(s): Paul A Clark, Abraham J Al-Ahmad, Tongcheng Qian, Ray R Zhang, Hannah K Wilson, Jamey P Weichert, Sean P Palecek, John S Kuo, Eric V Shusta

Journal: Mol. Pharm.. 2016 09;13(9):3341-9.

 

Cancer-targeting alkylphosphocholine (APC) analogues are being clinically developed for diagnostic imaging, intraoperative visualization, and therapeutic applications. These APC analogues derived from chemically synthesized phospholipid ethers were identified and optimized for cancer-targeting ...

Last Updated: 31 Dec 1969

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Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases.
 

Author(s): Deepak Kanojia, Irina V Balyasnikova, Ramin A Morshed, Richard T Frank, Dou Yu, Lingjiao Zhang, Drew A Spencer, Julius W Kim, Yu Han, Dihua Yu, Atique U Ahmed, Karen S Aboody, Maciej S Lesniak

Journal: Stem Cells. 2015 Oct;33(10):2985-94.

 

The treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer has been revolutionized by trastuzumab. However, longer survival of these patients now predisposes them to forming HER2 positive brain metastases, as the therapeutic antibodies cannot cross ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brain Stem Cancer" returned 12 free, full-text review articles on human participants. First 3 results:

Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications.
 

Author(s): Tamara J Abou-Antoun, James S Hale, Justin D Lathia, Stephen M Dombrowski

Journal: Neurotherapeutics. 2017 04;14(2):372-384.

 

Brain tumors represent some of the most malignant cancers in both children and adults. Current treatment options target the majority of tumor cells but do not adequately target self-renewing cancer stem cells (CSCs). CSCs have been reported to resist the most aggressive radiation ...

Last Updated: 31 Dec 1969

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Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine.
 

Author(s): Sang-Soo Kim, Joe B Harford, Kathleen F Pirollo, Esther H Chang

Journal: Biochem. Biophys. Res. Commun.. 2015 Dec;468(3):485-9.

 

Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the blood-brain barrier (BBB) play a major role in the poor prognosis of GBM patients. Accumulated evidence suggests that in many ...

Last Updated: 31 Dec 1969

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It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain.
 

Author(s): Derek H Janssens, Cheng-Yu Lee

Journal: Semin. Cell Dev. Biol.. 2014 Apr;28():63-9.

 

During malignant transformation the cells of origin give rise to cancer stem cells which possess the capacity to undergo limitless rounds of self-renewing division, regenerating themselves while producing more tumor cells. Within normal tissues, a limitless self-renewal capacity is ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Nimotuzumab in Combination With Radio-chemotherapy for the Treatment of Brainstem Tumor in Children
 

Status: Recruiting

Condition Summary: Childhood Brain Stem Neoplasm

 

Last Updated: 14 Oct 2018

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Vegetative Monitoring During Brainstem-associated Surgery
 

Status: Recruiting

Condition Summary: Brain Tumor, Recurrent; Vestibular Schwannoma; Brainstem Neoplasm; Brainstem Glioma

 

Last Updated: 7 Sep 2018

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