Brugada Syndrome

Common Name(s)

Brugada Syndrome

Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm (arrhythmia). Signs and symptoms usually develop in adulthood and include ventricular arrhythmia that can cause fainting, seizures, difficulty breathing, or sudden death. These complications often occur when an affected person is resting or asleep. Brugada syndrome is inherited in an autosomal dominant manner and may be caused by a mutation in any of several genes (most commonly the SCN5A gene). In many cases, the genetic cause is not identified. There have also been reports of acquired Brugada syndrome which have been associated with adverse reactions to certain drugs or other substances. Treatment may include use of an implantable cardioverter defibrillator (ICD) in people with a history of fainting or heart attack.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

Last Updated: 23 Apr 2015

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Brugada Syndrome" for support, advocacy or research.

SADS (Sudden Arrhythmia Death Syndromes) Foundation

Our mission is to save the lives of young people who are genetically predisposed to sudden death due to cardiac arrhythmia and to provide education and support to families and the medical community.

http://www.StopSADS.org

Last Updated: 23 Apr 2015

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General Support Organizations

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General Resources

SADS Foundation Website

Information on living with SADS, diagnosis, treatment, prevention, and advocacy/education.

Updated 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Brugada Syndrome" returned 354 free, full-text research articles on human participants. First 3 results:

[Acute chest pain revealing a Brugada syndrome].
 

Author(s): Rakotoniaina Masinarivo Daniella, Rasolonjatovo Anjaramalala, Ramiandrisoa, Raveloson Freddie, Rakotoarimanana Solofonirina, Rabearivony Nirina

Journal:

 

The aim of this case study was to evaluate electrocardiographic diagnosis of Brugada syndrome. Our study involved a 43-year old man of Indian origin coming for consultation due to acute chest pain. The patient suffered from untreated stage 2 hypertension and had a family history of ...

Last Updated: 15 Mar 2017

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Outcomes of Brugada Syndrome Patients with Coronary Artery Vasospasm.
 

Author(s): Shingo Kujime, Harumizu Sakurada, Naoki Saito, Yoshinari Enomoto, Naoshi Ito, Keijiro Nakamura, Seiji Fukamizu, Tamotsu Tejima, Yuzuru Yambe, Mitsuhiro Nishizaki, Mahito Noro, Masayasu Hiraoka, Kaoru Sugi

Journal: Intern. Med.. 2017 ;56(2):129-135.

 

Objective To evaluate the outcomes of patients with concomitant Brugada syndrome and coronary artery vasospasm. Methods Patients diagnosed with Brugada syndrome with an implantable cardiac defibrillator were retrospectively investigated, and the coexistence of vasospasm was evaluated. ...

Last Updated: 16 Jan 2017

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Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.
 

Author(s): Ping Liang, Karim Sallam, Haodi Wu, Yingxin Li, Ilanit Itzhaki, Priyanka Garg, Ying Zhang, Vittavat Vermglinchan, Feng Lan, Mingxia Gu, Tingyu Gong, Yan Zhuge, Chunjiang He, Antje D Ebert, Veronica Sanchez-Freire, Jared Churko, Shijun Hu, Arun Sharma, Chi Keung Lam, Melvin M Scheinman, Donald M Bers, Joseph C Wu

Journal: J. Am. Coll. Cardiol.. 2016 Nov;68(19):2086-2096.

 

Brugada syndrome (BrS), a disorder associated with characteristic electrocardiogram precordial ST-segment elevation, predisposes afflicted patients to ventricular fibrillation and sudden cardiac death. Despite marked achievements in outlining the organ level pathophysiology of the ...

Last Updated: 4 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Brugada Syndrome" returned 52 free, full-text review articles on human participants. First 3 results:

The Brugada Syndrome - From Gene to Therapy.
 

Author(s): Antonio Curcio, Giuseppe Santarpia, Ciro Indolfi

Journal: Circ. J.. 2017 Feb;81(3):290-297.

 

It is almost a quarter of century that a pioneering work of 2 researchers named Brugada brought the entire scientific community to understanding the molecular, clinical, and electrophysiological aspects of a distinctive syndrome. It affects mainly young adults with syncope and/or ...

Last Updated: 10 Jan 2017

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Risk factors for cardiac events in patients with Brugada syndrome: A PRISMA-compliant meta-analysis and systematic review.
 

Author(s): Wenqing Wu, Li Tian, Jinshan Ke, Yi Sun, Ruixia Wu, Jianfang Zhu, Qinmei Ke

Journal: Medicine (Baltimore). 2016 Jul;95(30):e4214.

 

Inconsistent results have been reported about the risk stratification of patients with Brugada syndrome. We have summarized the evidence regarding the strength of association between 6 risk factors (family history of sudden cardiac death [SCD] or syncope, inducible ventricular arrhythmias ...

Last Updated: 30 Jul 2016

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Relationship Between Arrhythmogenic Right Ventricular Cardiomyopathy and Brugada Syndrome: New Insights From Molecular Biology and Clinical Implications.
 

Author(s): Domenico Corrado, Alessandro Zorzi, Marina Cerrone, Ilaria Rigato, Marco Mongillo, Barbara Bauce, Mario Delmar

Journal: Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003631.

 

Last Updated: 18 Mar 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ablation in Brugada Syndrome for the Prevention of VF
 

Status: Not yet recruiting

Condition Summary: Brugada Syndrome

 

Last Updated: 26 Sep 2016

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Diagnostic Value and Safety of Flecainide Infusion Test in Brugada Syndrome
 

Status: Recruiting

Condition Summary: Brugada Syndrome; Arrhythmogenic Right Ventricular Cardiomyopathy

 

Last Updated: 20 Mar 2017

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Empiric Quinidine for Asymptomatic Brugada Syndrome
 

Status: Recruiting

Condition Summary: Arrhythmia

 

Last Updated: 8 Jan 2017

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