CANOMAD Syndrome

Common Name(s)

CANOMAD Syndrome

CANOMAD syndrome is a rare chronic immune-mediated demyelinating polyneuropathy. CANOMAD stands for Chronic Ataxic Neuropathy Ophtalmoplegia IgM paraprotein Cold Agglutinins Disialosyl antibodies. Signs and symptoms of CANOMAD may include loss of muscle, tendon, and joint sensation, abnormal gait (walk), ataxia, tingling sensation on the skin around the mouth or extremities, paralysis of eye muscles, difficulty swallowing and speaking, and rarely respiratory muscle weakness. This condition is caused by the presence of anti-diasialosyl antibodies in the body.  Oral or intravenous corticosteroids, §-interferons, plasma exchange, intravenous immunoglobulin, and cytotoxic drugs have all been used in treating CANOMAD with limited success.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "CANOMAD Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "CANOMAD Syndrome" returned 1 free, full-text research articles on human participants. First 3 results:

[Identification and characterization of a monoclonal IgM reacting with disialylated gangliosides recognizing the CANOMAD syndrome].
 

Author(s): Ismael Boussaïd, Françoise Bouhour, Christophe Vial, Christiane Caudie

Journal: Ann. Biol. Clin. (Paris). ;69(4):476-80.

 

We reported the laboratory phenotype of a monoclonal IgM-lambda against disialylated gangliosides, in a 81-year-old man admitted to a neurological department because of the progressive development of distal paresthesias, gait unsteadiness, difficulty to walk and having falls. Serological ...

Last Updated: 7 Sep 2011

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Reviews from the PubMed Database

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The terms "CANOMAD Syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.