Corticobasal degeneration

Common Name(s)

Corticobasal degeneration, CBD

Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal degeneration" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

Last Updated: 5 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal degeneration" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

http://www.pspassociation.org.uk/

Last Updated: 5 Jun 2015

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General Support Organizations

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General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

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Newsletter

Quarterly publication (past and present)

Updated 30 Apr 2014

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CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

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Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corticobasal degeneration" returned 65 free, full-text research articles on human participants. First 3 results:

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
 

Author(s): Jennifer S Yokoyama, Celeste M Karch, Chun C Fan, Luke W Bonham, Naomi Kouri, Owen A Ross, Rosa Rademakers, Jungsu Kim, Yunpeng Wang, Günter U Höglinger, Ulrich Müller, Raffaele Ferrari, John Hardy, , Parastoo Momeni, Leo P Sugrue, Christopher P Hess, A James Barkovich, Adam L Boxer, William W Seeley, Gil D Rabinovici, Howard J Rosen, Bruce L Miller, Nicholas J Schmansky, Bruce Fischl, Bradley T Hyman, Dennis W Dickson, Gerard D Schellenberg, Ole A Andreassen, Anders M Dale, Rahul S Desikan

Journal: Acta Neuropathol.. 2017 May;133(5):825-837.

 

Corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) and a subset of frontotemporal dementia (FTD) are neurodegenerative disorders characterized by tau inclusions in neurons and glia (tauopathies). Although clinical, pathological and genetic evidence suggests overlapping ...

Last Updated: 31 Dec 1969

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Multimodal evaluation demonstrates in vivoF-AV-1451 uptake in autopsy-confirmed corticobasal degeneration.
 

Author(s): Corey T McMillan, David J Irwin, Ilya Nasrallah, Jeffrey S Phillips, Meredith Spindler, Katya Rascovsky, Kylie Ternes, Charles Jester, David A Wolk, Linda K Kwong, Virginia M-Y Lee, Edward B Lee, John Q Trojanowski, Murray Grossman

Journal: Acta Neuropathol.. 2016 12;132(6):935-937.

 

Last Updated: 31 Dec 1969

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Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
 

Author(s): Monica Sanchez-Contreras, Michael G Heckman, Pawel Tacik, Nancy Diehl, Patricia H Brown, Alexandra I Soto-Ortolaza, Elizabeth A Christopher, Ronald L Walton, Owen A Ross, Lawrence I Golbe, Neill Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson, Rosa Rademakers

Journal: Mov. Disord.. 2017 Jan;32(1):115-123.

 

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common genetic cause of Parkinson's disease (PD). Unexpectedly, tau pathology has been reported in a subset of LRRK2 mutation carriers.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corticobasal degeneration" returned 5 free, full-text review articles on human participants. First 3 results:

Cognitive dysfunction in corticobasal degeneration.
 

Author(s): Laís Machado de Oliveira, Igor Barcellos, Hélio A G Teive, Renato Puppi Munhoz

Journal: Arq Neuropsiquiatr. 2017 Aug;75(8):570-579.

 

Corticobasal degeneration (CBD) was originally described as a distinct clinicopathological entity in 1967. Since then, different phenotypic presentations have emerged as possible manifestations of CBD histopathological findings. In addition, pathophysiological findings and the molecular ...

Last Updated: 31 Dec 1969

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Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.
 

Author(s): Keith A Josephs

Journal: J. Neurol.. 2015 Mar;262(3):783-8.

 

It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative ...

Last Updated: 31 Dec 1969

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Dystonia in corticobasal degeneration: a review of the literature on 404 pathologically proven cases.
 

Author(s): Maria Stamelou, Araceli Alonso-Canovas, Kailash P Bhatia

Journal: Mov. Disord.. 2012 May;27(6):696-702.

 

Dystonia is considered one of the classical features of corticobasal degeneration and is reported in up to 83% in clinical, not pathologically confirmed, series. Here, we aimed to establish the frequency and the clinical characteristics of dystonia in CBD by reviewing the literature ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy (PSP); Corticobasal Degeneration; Multiple System Atrophy (MSA)

 

Last Updated: 17 May 2016

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Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.
 

Status: Recruiting

Condition Summary: Essential Tremor; Multiple System Atrophy; Corticobasal Degeneration; Supranuclear Palsy, Progressive; Parkinson Disease

 

Last Updated: 8 Feb 2017

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4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
 

Status: Recruiting

Condition Summary: Corticobasal Degeneration (CBD); Corticobasal Syndrome (CBS); Cortical-basal Ganglionic Degeneration (CBGD); Progressive Supranuclear Palsy (PSP); Nonfluent Variant Primary Progressive Aphasia (nfvPPA); Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)

 

Last Updated: 15 Nov 2016

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