Creutzfeldt-Jakob disease

Common Name(s)

Creutzfeldt-Jakob disease, CJD

Creutzfeldt-Jakob disease (CJD) is a type of rapidly progressive brain disorder known as prion disease. Prion disease is very rare and affects about one in every one million people per year. Symptoms of CJD typically develop around age 60 and can include trouble with memory along with changes in behavior, vision, and coordination. As the disease progresses, the severity of the symptoms increase.

The three variations of CJD are labeled as sporadic, hereditary, and acquired. Researchers believe the sporadic variation, which is most common, could be due to an incorrectly folded protein in the body, called an infectious prion. The prions clump together and cause damage to the brain, leading to the symptoms of CJD. The hereditary variation, which occurs much less often, is also caused by clumped prions. However, in the hereditary version, the abnormally folded prions are caused by a change (mutation) in the PRNP gene. The acquired variation of CJD is the least common and can occur when an individual comes in contact with the brain tissue or spinal fluid of an affective organism, such as eating the brain tissue of an affected cow (also known as mad cow disease). This variation accounts for about 1% of CJD cases.

Because CJD has symptoms similar to other forms of dementia, a doctor may attempt to rule out other conditions before suggesting a diagnosis of CJD. A medical professional may also perform a brain scan, such as an MRI, to look for changes in the brain tissue that are characteristic of CJD. The current treatments available for CJD focus on minimizing the symptoms associated with the disease. Researchers are trying to better understand what causes CJD in order to develop more effective treatments. If you or a family member has been diagnosed with CJD, talk with your doctor and specialists about the most current treatment options. Support groups are a good resource for additional information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Creutzfeldt-Jakob disease" for support, advocacy or research.

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The CJD Foundation

The Creutzfeldt-Jakob Disease Foundation consists of members who are concerned about the complexity of issues surrounding this fatal brain disease. Our mission is to support families and loved ones touched by CJD.

Last Updated: 11 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Creutzfeldt-Jakob disease" for support, advocacy or research.

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The CJD Foundation

The Creutzfeldt-Jakob Disease Foundation consists of members who are concerned about the complexity of issues surrounding this fatal brain disease. Our mission is to support families and loved ones touched by CJD.

http://www.cjdfoundation.org

Last Updated: 11 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Creutzfeldt-Jakob disease" returned 621 free, full-text research articles on human participants. First 3 results:

Low mood, visual hallucinations, and falls - heralding the onset of rapidly progressive probable sporadic Creutzfeldt-Jakob disease in a 73-year old: a case report.
 

Author(s): Daniel Martin Klotz, Rose Sarah Penfold

Journal:

 

Creutzfeldt-Jakob disease is a rare and rapidly fatal neurodegenerative disease. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, to perform appropriate investigations, and ...

Last Updated: 31 Dec 1969

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Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito.
 

Author(s): Germaine Eleanor Torres Herrán, Andrés Damián Ortega Herrera, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos, Edgar Patricio Correa Díaz

Journal:

 

Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. So far in Ecuador, we do not know what the prevalence or incidence is, and only one case ...

Last Updated: 31 Dec 1969

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Update: Dura Mater Graft-Associated Creutzfeldt-Jakob Disease - Japan, 1975-2017.
 

Author(s): Ryusuke Ae, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Masahito Yamada, Tadashi Tsukamoto, Hidehiro Mizusawa, Ermias D Belay, Lawrence B Schonberger

Journal:

 

Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder that, according to the most well accepted hypothesis (1), is caused by replicating, transmissible, abnormal forms of a host-encoded prion protein (prions). Most CJD cases occur spontaneously (sporadic CJD) or are ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Creutzfeldt-Jakob disease" returned 56 free, full-text review articles on human participants. First 3 results:

Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: a case report and literature review.
 

Author(s): Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada, Norihito Yamada

Journal:

 

Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding.

Last Updated: 31 Dec 1969

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Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence.
 

Author(s): Fernando J García López, María Ruiz-Tovar, Javier Almazán-Isla, Enrique Alcalde-Cabero, Miguel Calero, Jesús de Pedro-Cuesta

Journal: Euro Surveill.. 2017 10;22(43):.

 

Sporadic Creutzfeldt-Jakob disease (sCJD) is potentially transmissible to humans.

Last Updated: 31 Dec 1969

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Can Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer?
 

Author(s): Gabor G Kovacs

Journal: Prion. 2016 09;10(5):369-376.

 

Recent studies on iatrogenic Creutzfeldt-Jakob disease (CJD) raised concerns that one of the hallmark lesions of Alzheimer disease (AD), amyloid-β (Aβ), may be transmitted from human-to-human. The neuropathology of AD-related lesions is complex. Therefore, many aspects need to be ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Role of the Coagulation Pathway at the Synapse in Prion Diseases
 

Status: Not yet recruiting

Condition Summary: Creutzfeldt-Jakob Syndrome

 

Last Updated: 23 Jun 2015

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Genetic Characterization of Movement Disorders and Dementias
 

Status: Recruiting

Condition Summary: Ataxia; Dystonia; Parkinson's Disease; Amyotrophic Lateral Sclerosis; Corticobasal Degeneration; Multiple System Atrophy; Alzheimer's Disease; Lewy Body Dementia; Parkinson Disease-Dementia; Dentatorubral-pallidoluysian Atrophy; Creutzfeldt-Jakob Disease and Fatal Familial Insomnia; Fragile X-associated Tremor/Ataxia Syndrome; Krabbe's Disease; Niemann-Pick Disease, Type C; Neuronal Ceroid Lipofuscinosis

 

Last Updated: 17 Oct 2018

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