Calciphylaxis

Common Name(s)

Calciphylaxis

Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs.  The lack of blood flow (ischemia) damages healthy tissue and causes it to die (necrosis).  The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can develop and become infected easily.  Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.  These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more than a few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure.   The exact cause of calciphylaxis is unknown.   Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Calciphylaxis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Calciphylaxis" returned 112 free, full-text research articles on human participants. First 3 results:

Calciphylaxis.
 

Author(s): Sagar U Nigwekar, Ravi Thadhani, Vincent M Brandenburg

Journal: N. Engl. J. Med.. 2018 07;379(4):399-400.

 

Last Updated: 31 Dec 1969

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A case report of pediatric calciphylaxis-a rare and potentially fatal under diagnosed condition.
 

Author(s): Magdalena Stârcea, Cristina Gavrilovici, Andra Elsayed, Mihaela Munteanu, Vasile Valeriu Lupu, Elena Cojocaru, Ingrith Miron, Lucian Miron

Journal: Medicine (Baltimore). 2018 Jul;97(27):e11300.

 

Though to be rare, calcific uremic arteriolophathy (CUA) is an ectopic calcification entity causing pain and disabilities in patients with chronic renal insufficiency, thus increasing the morbidity and mortality.

Last Updated: 31 Dec 1969

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Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis.
 

Author(s): Sagar U Nigwekar, Pawina Jiramongkolchai, Florian Wunderer, Emily Bloch, Rika Ichinose, Rosalynn M Nazarian, Ravi I Thadhani, Rajeev Malhotra, Donald B Bloch

Journal: Am. J. Nephrol.. 2017 ;46(5):429-438.

 

The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Calciphylaxis" returned 21 free, full-text review articles on human participants. First 3 results:

Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease.
 

Author(s): Swati Prabhakar, Ahmad M Tuffaha

Journal:

 

BACKGROUND Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with ...

Last Updated: 31 Dec 1969

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Calciphylaxis.
 

Author(s): Sagar U Nigwekar

Journal: Curr. Opin. Nephrol. Hypertens.. 2017 07;26(4):276-281.

 

Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in ...

Last Updated: 31 Dec 1969

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Warfarin-Associated Nonuremic Calciphylaxis.
 

Author(s): Wesley Yung-Hsu Yu, Tina Bhutani, Rachel Kornik, Laura B Pincus, Theodora Mauro, Michael D Rosenblum, Lindy P Fox

Journal: JAMA Dermatol. 2017 Mar;153(3):309-314.

 

Classic calciphylaxis associated with renal failure is a life-threatening disease. Warfarin-associated calciphylaxis without renal injury has been described, but whether it is a subset of classic calciphylaxis or a different entity remains unknown. We describe 1 case of warfarin-associated ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 24 Jun 2018

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A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients
 

Status: Recruiting

Condition Summary: Calciphylaxis

 

Last Updated: 24 Jun 2018

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European Calciphylaxis Registry Network
 

Status: Recruiting

Condition Summary: Calcific Uremic Arteriolopathy (CUA); Calciphylaxis

 

Last Updated: 13 Oct 2016

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