Hereditary cancer

Common Name(s)

Hereditary cancer, Cancer predisposition, Cancer, Hereditary

Hereditary cancer, or inherited cancer, is cancer that occurs as a result of a genetic change (mutation) that a person is born with. All cancer is a result of genetic changes that cause a cell to divide faster than it should. These changes can occur in a gene that slows down cell division, in a gene that speeds up cell division, or in a gene that is in charge of repairing genetic changes. These are collectively known as cancer susceptibility genes. People have two copies of these genes in all of their cells.

As a person ages and gets exposed to different things in the environment, such as smoking or the sun, their genes are changed (acquired mutations). Most cancer occurs because both copies of a person’s cancer susceptibility gene get changed over time (sporadic cancer). In hereditary cancer, a person is born with a change in one copy of a cancer susceptibility gene. This significantly increases their lifetime risk of cancer because it is more likely, and takes less time, to get a change in the one remaining unchanged gene copy.

About 10% of all cancer is hereditary and there are many types, depending on the gene that is affected. The most common forms of hereditary cancer are breast cancer, ovarian cancer, and colorectal cancer. Factors that increase the risk of cancer being hereditary include multiple family members affected with similar types of cancer, cancer at a young age (less than 50 years) in the family, rare forms of cancer in the family (such as kidney cancer or breast cancer in a man), and more than one type of primary cancer in a person (a woman with both breast and ovarian cancer). If you have signs of hereditary cancer in your family, talk with a genetic counselor about the likelihood of it being hereditary as well as genetic testing options. Diagnosing hereditary cancer in a family can help to determine a person’s cancer risk as well as determine cancer surveillance recommendations.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary cancer" returned 640 free, full-text research articles on human participants. First 3 results:

Frequency of breast cancer with hereditary risk features in Spain: Analysis from GEICAM "El Álamo III" retrospective study.
 

Author(s): Iván Márquez-Rodas, Marina Pollán, María José Escudero, Amparo Ruiz, Miguel Martín, Ana Santaballa, Purificación Martínez Del Prado, Norberto Batista, Raquel Andrés, Antonio Antón, Antonio Llombart, Antonio Fernandez Aramburu, Encarnación Adrover, Sonia González, Miguel Angel Seguí, Lourdes Calvo, José Lizón, Álvaro Rodríguez Lescure, Teresa Ramón Y Cajal, Gemma Llort, Carlos Jara, Eva Carrasco, Sara López-Tarruella

Journal:

 

To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain.

Last Updated: 6 Oct 2017

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The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels.
 

Author(s): Pi-Lin Sung, Kuo-Chang Wen, Yi-Jen Chen, Ta-Chung Chao, Yi-Fang Tsai, Ling-Ming Tseng, Jian-Tai Timothy Qiu, Kuan-Chong Chao, Hua-Hsi Wu, Chi-Mu Chuang, Peng-Hui Wang, Chi-Ying F Huang

Journal:

 

An important role of genetic factors in the development of breast cancer (BC) or ovarian cancer (OC) in Taiwanese (ethnic Chinese) patients has been suggested. However, other than germline BRCA1 or BRCA2 mutations, which are related to hereditary breast-ovarian cancer (HBOC), cancer-predisposition ...

Last Updated: 29 Sep 2017

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DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer.
 

Author(s): Charité N Ricker, Diana L Hanna, Cheng Peng, Nathalie T Nguyen, Mariana C Stern, Stephanie L Schmit, Greg E Idos, Ravi Patel, Steven Tsai, Veronica Ramirez, Sonia Lin, Vinay Shamasunadara, Afsaneh Barzi, Heinz-Josef Lenz, Jane C Figueiredo

Journal: Cancer. 2017 Oct;123(19):3732-3743.

 

The landscape of hereditary syndromes and clinicopathologic characteristics among US Latino/Hispanic individuals with colorectal cancer (CRC) remains poorly understood.

Last Updated: 22 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary cancer" returned 114 free, full-text review articles on human participants. First 3 results:

Hereditary melanoma: Update on syndromes and management: Emerging melanoma cancer complexes and genetic counseling.
 

Author(s): Efthymia Soura, Philip J Eliades, Kristen Shannon, Alexander J Stratigos, Hensin Tsao

Journal: J. Am. Acad. Dermatol.. 2016 Mar;74(3):411-20; quiz 421-2.

 

Recent advances in cancer genomics have enabled the discovery of many cancer-predisposing genes that are being used to classify new familial melanoma/cancer syndromes. In addition to CDKN2A and CDK4, germline variants in TERT, MITF, and BAP1 have been added to the list of genes harboring ...

Last Updated: 19 Feb 2016

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Hereditary cancer syndromes: utilizing DNA repair deficiency as therapeutic target.
 

Author(s): Gaurav Goyal, Tiffany Fan, Peter Todd Silberstein

Journal: Fam. Cancer. 2016 Jul;15(3):359-66.

 

Human cells have numerous repair mechanisms to counteract various insults incurred on the DNA. Any mutation in these repair mechanisms can lead to accumulation of DNA errors and carcinogenesis. This review aims to discuss the therapeutic options in the two most common DNA repair deficient ...

Last Updated: 9 Jun 2016

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Genetic testing for hereditary cancer predisposition: BRCA1/2, Lynch syndrome, and beyond.
 

Author(s): M J Hall, E I Obeid, S C Schwartz, G Mantia-Smaldone, A D Forman, M B Daly

Journal: Gynecol. Oncol.. 2016 Mar;140(3):565-74.

 

Obstetrician/gynecologists and gynecologic oncologists serve an integral role in the care of women at increased hereditary risk of cancer. Their contribution includes initial identification of high risk patients, screening procedures like bimanual exam, trans-vaginal ultrasound and ...

Last Updated: 24 Feb 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Combined Breast Cancer Risk Study
 

Status: Recruiting

Condition Summary: Hereditary Cancer

 

Last Updated: 31 Aug 2017

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Familial Cancer Registry and DNA Bank
 

Status: Recruiting

Condition Summary: Cancer

 

Last Updated: 6 Mar 2014

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Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix; Goiter; Sarcoma; Pineoblastoma; Pituitary Tumors; Wilms Tumor

 

Last Updated: 16 Jul 2017

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