Hereditary cancer

Common Name(s)

Hereditary cancer, Cancer predisposition, Cancer, Hereditary

Hereditary cancer, or inherited cancer, is cancer that occurs as a result of a genetic change (mutation) that a person is born with. All cancer is a result of genetic changes that cause a cell to divide faster than it should. These changes can occur in a gene that slows down cell division, in a gene that speeds up cell division, or in a gene that is in charge of repairing genetic changes. These are collectively known as cancer susceptibility genes. People have two copies of these genes in all of their cells.

As a person ages and gets exposed to different things in the environment, such as smoking or the sun, their genes are changed (acquired mutations). Most cancer occurs because both copies of a person’s cancer susceptibility gene get changed over time (sporadic cancer). In hereditary cancer, a person is born with a change in one copy of a cancer susceptibility gene. This significantly increases their lifetime risk of cancer because it is more likely, and takes less time, to get a change in the one remaining unchanged gene copy.

About 10% of all cancer is hereditary and there are many types, depending on the gene that is affected. The most common forms of hereditary cancer are breast cancer, ovarian cancer, and colorectal cancer. Factors that increase the risk of cancer being hereditary include multiple family members affected with similar types of cancer, cancer at a young age (less than 50 years) in the family, rare forms of cancer in the family (such as kidney cancer or breast cancer in a man), and more than one type of primary cancer in a person (a woman with both breast and ovarian cancer). If you have signs of hereditary cancer in your family, talk with a genetic counselor about the likelihood of it being hereditary as well as genetic testing options. Diagnosing hereditary cancer in a family can help to determine a person’s cancer risk as well as determine cancer surveillance recommendations.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary cancer" for support, advocacy or research.

Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

View Details
FORCE: Facing Our Risk of Cancer Empowered

FORCE is a national nonprofit dedicated to fighting hereditary breast and ovarian cancer. With 50 outreach groups throughout the U.S., and international affiliates, FORCE programs provide support, education, advocacy, awareness and research specific to hereditary cancers. Our programs serve anyone with a BRCA mutation or a family history of cancer. FORCE was founded on the principle that no one should have to face hereditary breast and ovarian cancer alone.

http://www.facingourrisk.org

Last Updated: 5 May 2014

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary cancer" returned 658 free, full-text research articles on human participants. First 3 results:

Hereditary melanoma: a five-year study of Brazilian patients in a cancer referral center - phenotypic characteristics of probands and pathological features of primary tumors.
 

Author(s): Bianca Costa Soares de Sá, Luciana Facure Moredo, Elimar Elias Gomes, Erica Sara Souza de Araújo, João Pedreira Duprat

Journal: An Bras Dermatol. 2018 Jun;93(3):337-340.

 

Approximately five to 10% of all melanomas occur in families with hereditary predisposition and the main high-risk melanoma susceptibility gene is the CDKN2A.

Last Updated: 31 Dec 1969

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Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction.
 

Author(s): Michael J Kerins, John Milligan, James A Wohlschlegel, Aikseng Ooi

Journal: Cancer Sci.. 2018 Sep;109(9):2757-2766.

 

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary cancer syndrome characterized by inactivation of the Krebs cycle enzyme fumarate hydratase (FH). HLRCC patients are at high risk of developing kidney cancer of type 2 papillary morphology that is refractory to ...

Last Updated: 31 Dec 1969

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Validation of CZECANCA (CZEch CAncer paNel for Clinical Application) for targeted NGS-based analysis of hereditary cancer syndromes.
 

Author(s): Jana Soukupova, Petra Zemankova, Klara Lhotova, Marketa Janatova, Marianna Borecka, Lenka Stolarova, Filip Lhota, Lenka Foretova, Eva Machackova, Viktor Stranecky, Spiros Tavandzis, Petra Kleiblova, Michal Vocka, Hana Hartmannova, Katerina Hodanova, Stanislav Kmoch, Zdenek Kleibl

Journal:

 

Carriers of mutations in hereditary cancer predisposition genes represent a small but clinically important subgroup of oncology patients. The identification of causal germline mutations determines follow-up management, treatment options and genetic counselling in patients' families. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary cancer" returned 123 free, full-text review articles on human participants. First 3 results:

Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation.
 

Author(s): Hisashi Hasumi, Masahiro Yao

Journal: Cancer Sci.. 2018 Mar;109(3):581-586.

 

Although hereditary kidney cancer syndrome accounts for approximately five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting agents currently used for sporadic ...

Last Updated: 31 Dec 1969

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Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.
 

Author(s): Soraia Melo, Joana Figueiredo, Maria Sofia Fernandes, Margarida Gonçalves, Eurico Morais-de-Sá, João Miguel Sanches, Raquel Seruca

Journal:

 

The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene () are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases alterations result in the complete loss of E-cadherin associated ...

Last Updated: 31 Dec 1969

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Major hereditary gastrointestinal cancer syndromes: a narrative review.
 

Author(s): Lakshmi Manogna Chintalacheruvu, Trudy Shaw, Avanija Buddam, Osama Diab, Thamer Kassim, Sandeep Mukherjee, Henry T Lynch

Journal: J Gastrointestin Liver Dis. 2017 Jun;26(2):157-163.

 

Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cancer Health Assessments Reaching Many
 

Status: Recruiting

Condition Summary: Hereditary Cancer Syndrome

 

Last Updated: 7 Sep 2018

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Pancreatic Cancer Registry: For Any Person With a Personal or Family History
 

Status: Recruiting

Condition Summary: Pancreatic Cancer, ATM, BRCA, Hereditary Cancer

 

Last Updated: 8 Feb 2018

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Familial Cancer Registry and DNA Bank
 

Status: Recruiting

Condition Summary: Cancer

 

Last Updated: 6 Mar 2014

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