Invasive candidiasis

Common Name(s)

Invasive candidiasis, Candidemia

Invasive candidiasis is an infection that occurs when a type of fungus or yeast, called Candida, enters the bloodstream. The condition is called systemic candidiasis when only one organ system is involved. It is called disseminated candidiasis if the disease has spread to multiple organ systems. Candida are found naturally in many parts of the human body. When the fungus overgrows or enters other parts of the body, it can be dangerous.

Symptoms tend to vary between cases of invasive candidiasis depending on which organs are infected, but a fever is very common. Red bumps, which look like pimples without the pus, may be present as well. Depending on which organs are affected, blood clots and trouble passing urine are possible symptoms. Invasive candidiasis may also cause sepsis, which can cause damage to or failure of organ systems. In severe cases, invasive candidiasis can lead to blindness or even death. However, once diagnosed, invasive candidiasis can be treated.

Most people who suffer from invasive candidiasis contract it in a hospital, especially if they have a weakened immune system or they are recovering from surgery. Doctors will diagnose invasive candidiasis by testing to see if the yeast is present in places of the body where it is not found in healthy people, often the blood. In individuals with invasive candidiasis, levels of a carbohydrate called beta-glucan are often very high. Doctors may also test how much beta-glucan is present in your system in order to form a diagnosis.

There are multiple antifungal medications that can be prescribed to treat invasive candidiasis. Your doctor should suggest which treatment is right for you because certain types of the fungus respond differently to each medication. If you believe that you have invasive candidiasis, contact your doctor immediately. Support groups are also a good source of information and can help connect you with others affected by invasive candidiasis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Invasive candidiasis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Invasive candidiasis" returned 129 free, full-text research articles on human participants. First 3 results:

Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication.
 

Author(s): Francis Vekeman, Lisa Weiss, Jalal Aram, Raluca Ionescu-Ittu, Shahrzad Moosavi, Yongling Xiao, Wendy Y Cheng, Rachel H Bhak, Margaret Tawadrous, M Rita Capparella, Philippe Montravers, Mei Sheng Duh

Journal:

 

To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults.

Last Updated: 31 Dec 1969

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A Retrospective Assessment of Four Antigen Assays for the Detection of Invasive Candidiasis Among High-Risk Hospitalized Patients.
 

Author(s): Barbara Hartl, Iris Zeller, Angelika Manhart, Brigitte Selitsch, Cornelia Lass-Flörl, Birgit Willinger

Journal: Mycopathologia. 2018 Jun;183(3):513-519.

 

Because of their high mortality rates and non-specific symptoms, invasive Candida infections pose a huge diagnostic and therapeutic challenge. In this study, we evaluated the three mannan antigen assays Platelia, Platelia Plus and Serion, and the (1-3)-β-D-glucan assay Fungitell ...

Last Updated: 31 Dec 1969

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Invasive Candidiasis in pediatric patients at King Fahad Medical City in Central Saudi Arabia. A 5-year retrospective study.
 

Author(s): Zainab Almooosa, Gasmelseed Y Ahmed, Abeer Omran, Ayah AlSarheed, Afnan Alturki, Abdulaziz Alaqeel, Mohammed Alshehri, Tariq Alfawaz, Dayel AlShahrani

Journal: Saudi Med J. 2017 Nov;38(11):1118-1124.

 

To identify predisposing factors, species distribution, antifungal susceptibility, and outcome. Methods: This study is a retrospective chart review that was conducted at a children's hospital at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. One hundred twenty-nine children ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Invasive candidiasis" returned 46 free, full-text review articles on human participants. First 3 results:

Update on management of invasive candidiasis.
 

Author(s): F J Candel, C Pazos Pacheco, I Ruiz-Camps, E Maseda, M R Sánchez-Benito, A Montero, M Puig, F Gilsanz, J Aguilar, M Matesanz

Journal: Rev Esp Quimioter. 2017 Dec;30(6):397-406.

 

Given the growing incidence of invasive candidiasis in critically ill and haemato-oncological patients and its poor outcomes, an early diagnosis and treatment are need for get a better prognosis. This document reviews the current ap-proaches that help in diagnosis of invasive candidiasis ...

Last Updated: 31 Dec 1969

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Invasive candidiasis in the neutropenic patient.
 

Author(s): J Fortún, F Gioia

Journal: Rev Esp Quimioter. 2017 Sep;30 Suppl 1():22-25.

 

There are major differences in the epidemiology and prognosis of invasive candidiasis and candidemia in the neutropenic patient; however, a recent study performed in Spanish hospitals (Candipop) confirmed that mortality at 1 month is 30%, which is similar to that observed in the general ...

Last Updated: 31 Dec 1969

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Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy.
 

Author(s): Thierry Calandra, Jason A Roberts, Massimo Antonelli, Matteo Bassetti, Jean-Louis Vincent

Journal:

 

Invasive fungal infections, particularly those caused by Candida species, are not uncommon in critically ill patients and are associated with considerable morbidity and mortality. Diagnosis and management of these infections can be challenging. In this review, we will briefly discuss ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

NOBICS - NOvel BIomarker In Invasive CandidiasiS/Candida Sepsis
 

Status: Recruiting

Condition Summary: Invasive Candidiasis

 

Last Updated: 5 Dec 2017

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A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
 

Status: Recruiting

Condition Summary: Invasive Candidiases; Abdominal Infection

 

Last Updated: 30 Mar 2017

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Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis
 

Status: Recruiting

Condition Summary: Candidemia; Mycoses; Fungal Infection; Invasive Candidiases

 

Last Updated: 1 Oct 2018

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