Invasive candidiasis

Common Name(s)

Invasive candidiasis, Candidemia

Invasive candidiasis is an infection that occurs when a type of fungus or yeast, called Candida, enters the bloodstream. The condition is called systemic candidiasis when only one organ system is involved. It is called disseminated candidiasis if the disease has spread to multiple organ systems. Candida are found naturally in many parts of the human body. When the fungus overgrows or enters other parts of the body, it can be dangerous.

Symptoms tend to vary between cases of invasive candidiasis depending on which organs are infected, but a fever is very common. Red bumps, which look like pimples without the pus, may be present as well. Depending on which organs are affected, blood clots and trouble passing urine are possible symptoms. Invasive candidiasis may also cause sepsis, which can cause damage to or failure of organ systems. In severe cases, invasive candidiasis can lead to blindness or even death. However, once diagnosed, invasive candidiasis can be treated.

Most people who suffer from invasive candidiasis contract it in a hospital, especially if they have a weakened immune system or they are recovering from surgery. Doctors will diagnose invasive candidiasis by testing to see if the yeast is present in places of the body where it is not found in healthy people, often the blood. In individuals with invasive candidiasis, levels of a carbohydrate called beta-glucan are often very high. Doctors may also test how much beta-glucan is present in your system in order to form a diagnosis.

There are multiple antifungal medications that can be prescribed to treat invasive candidiasis. Your doctor should suggest which treatment is right for you because certain types of the fungus respond differently to each medication. If you believe that you have invasive candidiasis, contact your doctor immediately. Support groups are also a good source of information and can help connect you with others affected by invasive candidiasis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Invasive candidiasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Invasive candidiasis" returned 114 free, full-text research articles on human participants. First 3 results:

Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China-SCAN study.
 

Author(s): Na Cui, Hao Wang, Longxiang Su, Haibo Qiu, Ruoyu Li, Dawei Liu,

Journal:

 

To investigate the impact of initial antifungal therapeutic strategies on the prognosis of invasive Candida infections (ICIs) in intensive care units (ICUs) in China.

Last Updated: 24 Jan 2017

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ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients.
 

Author(s): Frederic Tissot, Samir Agrawal, Livio Pagano, Georgios Petrikkos, Andreas H Groll, Anna Skiada, Cornelia Lass-Flörl, Thierry Calandra, Claudio Viscoli, Raoul Herbrecht

Journal: Haematologica. 2017 Mar;102(3):433-444.

 

The European Conference on Infections in Leukemia (ECIL) provides recommendations for diagnostic strategies and prophylactic, pre-emptive or targeted therapy strategies for various types of infection in patients with hematologic malignancies or hematopoietic stem cell transplantation ...

Last Updated: 24 Dec 2016

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Safety, Efficacy, and Exposure-Response of Voriconazole in Pediatric Patients With Invasive Aspergillosis, Invasive Candidiasis or Esophageal Candidiasis.
 

Author(s): Judith M Martin, Mercedes Macias-Parra, Peter Mudry, Umberto Conte, Jean L Yan, Ping Liu, M Rita Capparella, Jalal A Aram

Journal: Pediatr. Infect. Dis. J.. 2017 Jan;36(1):e1-e13.

 

Data on safety and efficacy of voriconazole for invasive aspergillosis (IA) and invasive candidiasis/esophageal candidiasis (IC/EC) in pediatric patients are limited.

Last Updated: 16 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Invasive candidiasis" returned 44 free, full-text review articles on human participants. First 3 results:

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy.
 

Author(s): Thierry Calandra, Jason A Roberts, Massimo Antonelli, Matteo Bassetti, Jean-Louis Vincent

Journal:

 

Invasive fungal infections, particularly those caused by Candida species, are not uncommon in critically ill patients and are associated with considerable morbidity and mortality. Diagnosis and management of these infections can be challenging. In this review, we will briefly discuss ...

Last Updated: 27 May 2016

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Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia.
 

Author(s): Yvonne Schmiedel, Stephan Zimmerli

Journal:

 

Every year, Candida, Aspergillus, Cryptococcus and Pneumocystis infect an estimated two million individuals worldwide. Most are immunocompromised or critically ill. Candida is the most common fungal pathogen of the critically ill and of recipients of transplanted abdominal organs. ...

Last Updated: 23 Feb 2016

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T2MR and T2Candida: novel technology for the rapid diagnosis of candidemia and invasive candidiasis.
 

Author(s): Michael A Pfaller, Donna M Wolk, Thomas J Lowery

Journal: Future Microbiol. 2016 ;11(1):103-17.

 

Candidemia and other forms of invasive candidiasis pose a significant diagnostic challenge. In order to provide the best treatment, it is important to accurately detect the fungal infection and identify the species. Historically, diagnosis of Candida infections depended upon three ...

Last Updated: 24 Dec 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
 

Status: Recruiting

Condition Summary: Invasive Candidiases; Abdominal Infection

 

Last Updated: 30 Mar 2017

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BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia
 

Status: Recruiting

Condition Summary: Invasive Candidiasis

 

Last Updated: 11 Jul 2017

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Pharmacokinetics of Micafungin in Children on Extracorporeal Membrane Oxygenation
 

Status: Recruiting

Condition Summary: Invasive Candidiasis

 

Last Updated: 31 May 2017

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