Coronary microvascular disease

Common Name(s)

Coronary microvascular disease, Cardiac syndrome X

Coronary microvascular disease, also known as cardiac syndrome X, is a type of heart disease. The heart is a muscle that requires nutrients and oxygen, which is supplied by blood that travels through tubes or vessels called the “coronary arteries.” When these tubes become damaged or clogged, a patient can develop coronary artery disease. Coronary artery disease (CAD) can ultimately cause a blockage of blood flow in the heart and a heart attack. Coronary microvascular disease is a type of CAD characterized by damage to the smaller coronary blood vessels, which may potentially spasm and decrease blood flow to the heart. Coronary microvascular disease commonly develops in women, especially young women. The most common symptom of coronary microvascular disease is angina, or chest pain, that lasts longer than 10 minutes and even longer than 30 minutes. Fatigue, problems sleeping and shortness of breath are also symptoms. Symptoms are usually noticed during routine activities and times of mental stress. There is no specific test for coronary microvascular disease, but stress tests and imaging are often used. Mediations such as aspirin and beta blockers are the main treatment for coronary microvascular disease.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coronary microvascular disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Coronary microvascular disease" returned 30 free, full-text research articles on human participants. First 3 results:

Coronary microvascular dysfunction equivalent to left main coronary artery disease.
 

Author(s): Cafer Panç, Mehmet Kocaağa, Onur Erdoğan, Remzi Sarıkaya, Sabahattin Umman

Journal: Turk Kardiyol Dern Ars. 2017 Apr;45(3):278-280.

 

Coronary microvascular dysfunction, also known as cardiac syndrome X, is a clinical syndrome presenting with typical angina and evidence of myocardial ischemia in the absence of flow-limiting stenosis on coronary angiography. Of patients undergoing coronary angiography due to suspected ...

Last Updated: 21 Apr 2017

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A novel effective method for the assessment of microvascular function in male patients with coronary artery disease: a pilot study using laser speckle contrast imaging.
 

Author(s): J P Borges, G O Lopes, V Verri, M P Coelho, P M C Nascimento, D A Kopiler, E Tibirica

Journal:

 

Evaluation of microvascular endothelial function is essential for investigating the pathophysiology and treatment of cardiovascular and metabolic diseases. Although laser speckle contrast imaging technology is well accepted as a noninvasive methodology for assessing microvascular ...

Last Updated: 7 Sep 2016

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Coronary Microvascular Function and Cardiovascular Risk Factors in Women With Angina Pectoris and No Obstructive Coronary Artery Disease: The iPOWER Study.
 

Author(s): Naja Dam Mygind, Marie Mide Michelsen, Adam Pena, Daria Frestad, Nynne Dose, Ahmed Aziz, Rebekka Faber, Nis Høst, Ida Gustafsson, Peter Riis Hansen, Henrik Steen Hansen, C Noel Bairey Merz, Jens Kastrup, Eva Prescott

Journal:

 

The majority of women with angina-like chest pain have no obstructive coronary artery disease when evaluated with coronary angiography. Coronary microvascular dysfunction is a possible explanation and associated with a poor prognosis. This study evaluated the prevalence of coronary ...

Last Updated: 12 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Coronary microvascular disease" returned 7 free, full-text review articles on human participants. First 3 results:

Microvascular coronary dysfunction and ischemic heart disease: where are we in 2014?
 

Author(s): John W Petersen, Carl J Pepine

Journal: Trends Cardiovasc. Med.. 2015 Feb;25(2):98-103.

 

Many patients with angina and signs of myocardial ischemia on stress testing have no significant obstructive epicardial coronary disease. There are many potential coronary and non-coronary mechanisms for ischemia without obstructive epicardial coronary disease, and prominent among ...

Last Updated: 21 Feb 2015

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Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response.
 

Author(s): Zsolt Bagi, Zuzana Broskova, Attila Feher

Journal: Curr Vasc Pharmacol. 2014 May;12(3):453-61.

 

It is believed that obesity has detrimental effects on the coronary circulation. These include immediate changes in coronary arterial vasomotor responsiveness and the development of occlusive large coronary artery disease. Despite its critical role in regulating myocardial perfusion, ...

Last Updated: 21 May 2014

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Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms.
 

Author(s): Marcos A Rossi, Herbert B Tanowitz, Lygia M Malvestio, Mara R Celes, Erica C Campos, Valdecir Blefari, Cibele M Prado

Journal:

 

This review focuses on the short and bewildered history of Brazilian scientist Carlos Chagas's discovery and subsequent developments, the anatomopathological features of chronic Chagas cardiomyopathy (CCC), an overview on the controversies surrounding theories concerning its pathogenesis, ...

Last Updated: 8 Sep 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Microvascular Disease Exercise Trial
 

Status: Recruiting

Condition Summary: Coronary Microvascular Disease

 

Last Updated: 24 May 2016

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Whole-Heart Myocardial Blood Flow Quantification Using MRI
 

Status: Recruiting

Condition Summary: Coronary Artery Disease; Coronary Microvascular Disease

 

Last Updated: 1 Mar 2017

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Comprehensive Treatment of Angina in Women With Microvascular Dysfunction
 

Status: Recruiting

Condition Summary: Angina Pectoris; Coronary Microvascular Disease

 

Last Updated: 13 Feb 2017

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