Coronary microvascular disease

Common Name(s)

Coronary microvascular disease, Cardiac syndrome X

Coronary microvascular disease, also known as cardiac syndrome X, is a type of heart disease. The heart is a muscle that requires nutrients and oxygen, which is supplied by blood that travels through tubes or vessels called the “coronary arteries.” When these tubes become damaged or clogged, a patient can develop coronary artery disease. Coronary artery disease (CAD) can ultimately cause a blockage of blood flow in the heart and a heart attack. Coronary microvascular disease is a type of CAD characterized by damage to the smaller coronary blood vessels, which may potentially spasm and decrease blood flow to the heart. Coronary microvascular disease commonly develops in women, especially young women. The most common symptom of coronary microvascular disease is angina, or chest pain, that lasts longer than 10 minutes and even longer than 30 minutes. Fatigue, problems sleeping and shortness of breath are also symptoms. Symptoms are usually noticed during routine activities and times of mental stress. There is no specific test for coronary microvascular disease, but stress tests and imaging are often used. Mediations such as aspirin and beta blockers are the main treatment for coronary microvascular disease.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coronary microvascular disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Coronary microvascular disease" returned 36 free, full-text research articles on human participants. First 3 results:

Body Mass Index Is Associated With Microvascular Endothelial Dysfunction in Patients With Treated Metabolic Risk Factors and Suspected Coronary Artery Disease.
 

Author(s): Dirk J van der Heijden, Maarten A H van Leeuwen, Gladys N Janssens, Mattie J Lenzen, Peter M van de Ven, Etto C Eringa, Niels van Royen

Journal:

 

Obesity is key feature of the metabolic syndrome and is associated with high cardiovascular morbidity and mortality. Obesity is associated with macrovascular endothelial dysfunction, a determinant of outcome in patients with coronary artery disease. Here, we compared the influence ...

Last Updated: 31 Dec 1969

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Blood metabolomic fingerprint is distinct in healthy coronary and in stenosing or microvascular ischemic heart disease.
 

Author(s): Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Damiana Congia, Emanuela Locci, Federica Ascedu, Gianfranco De Candia, Mauro Cadeddu, Giorgio Lai, Raimondo Pirisi, Luigi Atzori, Giuseppe Mercuro

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The endothelium is a key variable in the pathogenesis of atherosclerosis and its complications, particularly coronary artery disease (CAD). Current evidence suggests that the endothelial status can be regarded as an integrated index of individual atherogenic and anti-atherogenic properties, ...

Last Updated: 31 Dec 1969

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Ranolazine in Symptomatic Diabetic Patients Without Obstructive Coronary Artery Disease: Impact on Microvascular and Diastolic Function.
 

Author(s): Nishant R Shah, Michael K Cheezum, Vikas Veeranna, Stephen J Horgan, Viviany R Taqueti, Venkatesh L Murthy, Courtney Foster, Jon Hainer, Karla M Daniels, Jose Rivero, Amil M Shah, Peter H Stone, David A Morrow, Michael L Steigner, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli

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Treatments for patients with myocardial ischemia in the absence of angiographic obstructive coronary artery disease are limited. In these patients, particularly those with diabetes mellitus, diffuse coronary atherosclerosis and microvascular dysfunction is a common phenotype and may ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Coronary microvascular disease" returned 7 free, full-text review articles on human participants. First 3 results:

Microvascular coronary dysfunction and ischemic heart disease: where are we in 2014?
 

Author(s): John W Petersen, Carl J Pepine

Journal: Trends Cardiovasc. Med.. 2015 Feb;25(2):98-103.

 

Many patients with angina and signs of myocardial ischemia on stress testing have no significant obstructive epicardial coronary disease. There are many potential coronary and non-coronary mechanisms for ischemia without obstructive epicardial coronary disease, and prominent among ...

Last Updated: 31 Dec 1969

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Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response.
 

Author(s): Zsolt Bagi, Zuzana Broskova, Attila Feher

Journal: Curr Vasc Pharmacol. 2014 May;12(3):453-61.

 

It is believed that obesity has detrimental effects on the coronary circulation. These include immediate changes in coronary arterial vasomotor responsiveness and the development of occlusive large coronary artery disease. Despite its critical role in regulating myocardial perfusion, ...

Last Updated: 31 Dec 1969

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Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms.
 

Author(s): Marcos A Rossi, Herbert B Tanowitz, Lygia M Malvestio, Mara R Celes, Erica C Campos, Valdecir Blefari, Cibele M Prado

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This review focuses on the short and bewildered history of Brazilian scientist Carlos Chagas's discovery and subsequent developments, the anatomopathological features of chronic Chagas cardiomyopathy (CCC), an overview on the controversies surrounding theories concerning its pathogenesis, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry
 

Status: Recruiting

Condition Summary: Hypertrophic; Ischemic; Restrictive Cardiomyopathy; Dilated Cardiomyopathies

 

Last Updated: 9 Apr 2018

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Whole-Heart Myocardial Blood Flow Quantification Using MRI
 

Status: Recruiting

Condition Summary: Coronary Artery Disease; Coronary Microvascular Disease

 

Last Updated: 9 Mar 2018

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Comprehensive Treatment of Angina in Women With Microvascular Dysfunction
 

Status: Recruiting

Condition Summary: Angina Pectoris; Coronary Microvascular Disease

 

Last Updated: 13 Feb 2017

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