Cataplexy

Common Name(s)

Cataplexy

Cataplexy is a symptom shown only in people with narcolepsy. Cataplexy is a sudden loss of muscle tone while awake that makes you unable to move. Strong emotions, such as laughter or anger, can trigger this. Most attacks last for less than 30 seconds and can be missed. Your head will suddenly fall forward, your jaw will become slack, and your knees will buckle. In severe cases, a person may fall and stay paralyzed for as long as several minutes.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cataplexy" returned 124 free, full-text research articles on human participants. First 3 results:

Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice.
 

Author(s): Panagis Drakatos, Dimosthenis Lykouras, Grainne D'Ancona, Sean Higgins, Nadia Gildeh, Raluca Macavei, Ivana Rosenzweig, Joerg Steier, Adrian J Williams, Rexford Muza, Brian D Kent, Guy Leschziner

Journal: Sleep Med.. 2017 Jul;35():80-84.

 

Sodium oxybate is licensed in Europe for the treatment of narcolepsy with cataplexy in adults. The aim of this study was to assess the efficacy and safety of sodium oxybate in clinical practice in patients with narcolepsy and cataplexy refractory to other treatments.

Last Updated: 31 Dec 1969

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Wide implications of a trial on pitolisant for cataplexy.
 

Author(s): Christian R Baumann

Journal: Lancet Neurol. 2017 03;16(3):173-174.

 

Last Updated: 31 Dec 1969

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Impact of sodium oxybate, modafinil, and combination treatment on excessive daytime sleepiness in patients who have narcolepsy with or without cataplexy.
 

Author(s): Jed Black, Todd Swick, Richard Bogan, Chinglin Lai, Lawrence P Carter

Journal: Sleep Med.. 2016 08;24():57-62.

 

Effects of sodium oxybate (SXB) on patients with narcolepsy with cataplexy (NC) or without cataplexy (NWOC) have not been separately evaluated in clinical trials.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cataplexy" returned 11 free, full-text review articles on human participants. First 3 results:

Rewiring brain circuits to block cataplexy in murine models of narcolepsy.
 

Author(s): Meng Liu, Carlos Blanco-Centurion, Priyattam J Shiromani

Journal: Curr. Opin. Neurobiol.. 2017 06;44():110-115.

 

Narcolepsy was first identified almost 130 years ago, but it was only 15 years ago that it was identified as a neurodegenerative disease linked to a loss of orexin neurons in the brain. It is unclear what causes the orexin neurons to die, but our strategy has been to place the gene ...

Last Updated: 31 Dec 1969

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Assessing sleepiness and cataplexy in children and adolescents with narcolepsy: a review of current patient-reported measures.
 

Author(s): Khadra Benmedjahed, Y Grace Wang, Jérémy Lambert, Christopher Evans, Steve Hwang, Jed Black, Murray W Johns

Journal: Sleep Med.. 2017 Apr;32():143-149.

 

The objective of this study was to review patient-reported outcome measures assessing excessive daytime sleepiness (EDS) or cataplexy in children or adolescents to determine their usefulness and limitations in pediatric narcolepsy assessment.

Last Updated: 31 Dec 1969

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[Narcolepsy with cataplexy: an autoimmune disease?].
 

Author(s): Louis Jacob, Yves Dauvilliers

Journal: Med Sci (Paris). 2014 Dec;30(12):1136-43.

 

Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Nov 2018

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Last Updated: 7 Nov 2018

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Last Updated: 8 Feb 2018

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