Cavernous angioma

Common Name(s)

Cavernous angioma, Cavernous hemangioma, Cerebral cavernous malformation (CCM), Cavernoma

A cavernous angioma is an abnormal collection of blood vessels in the brain, spinal cord, or other parts of the body. The abnormal vessels are usually clustered together and have bubble-like dilations filled with blood, called caverns. They can be present at birth (congenital) or can develop later. Individuals may have multiple cavernous angiomas of different sizes and at different locations.

Symptoms of cavernous angiomas vary depending on the location and size of the angioma. If the angioma is located away from vital organs and has strong vessel walls, the individual is not likely to show any symptoms. In other cases, such as for ones located in the brain, seizures may occur. Other potential symptoms include headaches, weakness in the arms or legs, memory or attention problems, balance problems, and vision problems. Bleeding is a possible complication that may occur when the angioma wall is ruptured. This is known as an overt hemorrhage, and can be life threatening.

Symptoms are usually first experienced between the ages of 20-30, although symptoms may start during childhood in more severe cases. Because cavernous angiomas can develop or grow as a person ages, adults are more likely to experience symptoms. The likelihood of developing cavernous angiomas is believed to be influenced by genetic factors. Hispanic Americans are at a higher risk of developing cavernous angiomas than other ethnic groups.

Cavernous angiomas are diagnosed by the symptoms and confirmed using imaging techniques. After detection, affected individuals have regular check-ups to look for changes in appearance or bleeding. Medication is often used to treat symptoms, such as headaches or seizures, or to help prevent complications, such as bleeding. When a cavernous angioma expands in size, bleeds, or causes seizures, surgery may be required. If you or your child has been diagnosed with a cavernous angioma, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cavernous angioma" for support, advocacy or research.

Angioma Alliance

It is our mission to inform, support, and empower individuals affected by cavernous angioma and drive research for a cure.

Last Updated: 13 Oct 2012

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Cavernoma Alliance UK

Cavernoma Alliance UK was established in 2005 by and for people affected by a cavernoma.

Last Updated: 15 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cavernous angioma" for support, advocacy or research.

Angioma Alliance

It is our mission to inform, support, and empower individuals affected by cavernous angioma and drive research for a cure.

http://www.angioma.org

Last Updated: 13 Oct 2012

View Details
Cavernoma Alliance UK

Cavernoma Alliance UK was established in 2005 by and for people affected by a cavernoma.

http://www.cavernoma.org.uk

Last Updated: 15 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cavernous angioma" returned 68 free, full-text research articles on human participants. First 3 results:

Solitary bone and brain metastasis in a patient with papillary thyroid carcinoma mimicking cavernous angioma.
 

Author(s): Eugene Han, Ye Yeon Lee, El Kim, Sun Young Kwon, Sang Pyo Kim, Hye Soon Kim, Mi Kyung Kim

Journal: Korean J. Intern. Med.. 2016 Sep;31(5):991-4.

 

Last Updated: 8 Sep 2016

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[Therapeutic effect of gamma knife on intracranial cavernous angioma].
 

Author(s): Ge Jia, Junmei Zhang, Zhiming Ma, Bin Qiu, Yonghong Hou

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Dec;39(12):1320-5.

 

To evaluate the therapeutic effect of gamma knife on patients with intracranial cavernous angioma (CA).

Last Updated: 29 Dec 2014

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Radiation-induced cavernous angioma in an adult.
 

Author(s): Damodar Rout, K M Geetha Sharmi, R Rajeswaran

Journal: Neurol India. ;62(5):572-3.

 

Last Updated: 12 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cavernous angioma" returned 15 free, full-text review articles on human participants. First 3 results:

Spinal intradural extramedullary cavernous angioma presenting with superficial siderosis and hydrocephalus: a case report and review of the literature.
 

Author(s): Nagaaki Katoh, Takuhiro Yoshida, Takeshi Uehara, Kiyoshi Ito, Kazuhiro Hongo, Shu-ichi Ikeda

Journal: Intern. Med.. 2014 ;53(16):1863-7.

 

A 36-year-old man with progressive hearing impairment visited our hospital complaining of a severe headache. A neurological examination revealed bilateral sensorineural hearing impairment, mild ataxia, hyperreflexia and mild cognitive dysfunction. Brain MRI demonstrated hydrocephalus ...

Last Updated: 18 Aug 2014

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Thoracic spinal cord cavernous angioma: a case report and review of the literature.
 

Author(s): Giovanni Grasso, Concetta Alafaci, Francesca Granata, Mariano Cutugno, Francesco Maria Salpietro, Francesco Tomasello

Journal:

 

Cavernous angiomas of the spinal cord are rare vascular malformations, which account for approximately 5 to 12 percent of spinal cord vascular lesions. They usually originate in the vertebrae, with occasional extension into the extradural space, and intramedullary cavernomas, even ...

Last Updated: 23 Aug 2014

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Solitary spinal epidural cavernous angioma: report of nine surgically treated cases and review of the literature.
 

Author(s): Mahmoud Reza Khalatbari, Kazem Abbassioun, Abbas Amirjmshidi

Journal: Eur Spine J. 2013 Mar;22(3):542-7.

 

We intend to report the largest series of spinal epidural cavernomas (SEC), discuss their clinical features, imaging characteristics, surgical findings, outcome analysis and compare them with similar reports in the literature.

Last Updated: 4 Mar 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Modifiers of Disease Severity in Cerebral Cavernous Malformations
 

Status: Recruiting

Condition Summary: Cavernous Angioma, Familial; Cerebral Cavernous Malformations; Cerebral Cavernous Hemangioma

 

Last Updated: 7 Sep 2017

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A Prospective Study on the Incidence and Related Risk Factors of Infantile Hemangioma in China
 

Status: Recruiting

Condition Summary: Infantile Hemangioma; Capillary Hemangioma; Capillary Hemangiomas; Hemangioma, Capillary Infantile; Strawberry Hemangioma

 

Last Updated: 1 Jun 2017

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Atorvastatin Therapy in Cerebral Cavernous Malformation, Exploratory Proof of Concept Trial
 

Status: Not yet recruiting

Condition Summary: Cerebral Cavernous Malformation

 

Last Updated: 31 May 2017

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