Celiac disease

Common Name(s)

Celiac disease, Celiac sprue

Celiac disease is an autoimmune response to gluten that causes damage to the lining of the gastrointestinal tract (stomach and intestines). Gluten is a protein found in wheat, rye and barley. When an individual with celiac disease eats gluten-containing foods, their immune system overreacts and causes swelling, inflammation and damage of the small intestines. This damage leads to poor absorption of nutrients from food, weight loss, bloating, and diarrhea. Other symptoms include iron deficiency that results in a low number of red blood cells (anemia), vitamin deficiencies, low bone mineral density (osteoporosis), itchy skin rashes, defects in the enamel of the teeth, chronic fatigue, joint pain, poor growth, delayed puberty, infertility, or repeated miscarriages. Neurological problems have also been associated with celiac disease and include migraine headaches, depression, attention deficit hyperactivity disorder (ADHD), and recurrent seizures (epilepsy). The exact cause of celiac disease is unknown. However, certain variants within the HLA-DQA1 and HLA-DQB1 genes, which play a role in the immune system, can increase a person’s risk for celiac disease. Infections, surgery, childbirth, and severe emotional stress can all trigger this condition.

In order to diagnose celiac disease, a doctor may need to conduct a biopsy (removal of tissue) of the small intestine. A detailed medical history, a physical examination, and blood tests may also be needed to diagnose this condition. Treatment involves the removal of gluten-containing foods from the diet. Your doctor may also recommend specific vitamin and mineral supplements to ensure you are receiving proper nutrients. Medication is also available to treat damage that may have occurred in the small intestines. Talk with your doctor to decide which treatment option is best for you. Support groups are also good resources for additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis, treatment, and a cure for celiac disease through advocacy, education, and research to improve the quality of life for all people affected by gluten-related disorders.

Last Updated: 26 May 2016

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Celiac disease" for support, advocacy or research.

Coeliac Society of Ireland

The mission of the Coeliac Society of Ireland is to improve the quality of life for Coeliacs and others who benefit from a gluten-free diet for medical reasons.

http://www.coeliac.ie

Last Updated: 1 May 2015

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Gluten Intolerance Group

The mission of the Gluten Intolerance Group of North America® is to support persons with gluten intolerances, celiac disease, dermatitis herpetiformis, and other gluten sensitivities, through consumer and industry services and programs that positively promote healthy lives.

http://www.gluten.net

Last Updated: 10 Mar 2015

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Celiac Disease Foundation

Celiac Disease Foundation drives diagnosis, treatment, and a cure for celiac disease through advocacy, education, and research to improve the quality of life for all people affected by gluten-related disorders.

http://celiac.org

Last Updated: 26 May 2016

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National Foundation for Celiac Awareness

The National Foundation for Celiac Awareness advances widespread understanding of celiac disease as a serious genetic autoimmune condition and works to secure early diagnosis and effective management. We empower our community to live life to the fullest, and serve as a leading and trusted resource that inspires hope, accelerates innovation and forges pathways to a cure.

http://www.CeliacCentral.org

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Celiac disease" returned 1140 free, full-text research articles on human participants. First 3 results:

Celiac disease in type 1 diabetes mellitus: What are the implications of early diagnosis?
 

Author(s): Ankur Gupta

Journal: Indian J. Med. Res.. 2018 02;147(2):207-208.

 

Last Updated: 31 Dec 1969

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PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN.
 

Author(s): Nicole Selleski, Lucas Malta Almeida, Fernanda Coutinho de Almeida, Claudia Beatriz Pratesi, Yanna Karla de Medeiros Nóbrega, Lenora Gandolfi

Journal: Arq Gastroenterol. ;55(1):82-85.

 

Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Almost all celiac patients carry immune recognition genes coding for HLA-DQ2.5 and DQ8 heterodimers. Over the last few years, great importance has been given to ...

Last Updated: 31 Dec 1969

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ASSOCIATION OF POTENTIAL CELIAC DISEASE AND REFRACTORY IRON DEFICIENCY ANEMIA IN CHILDREN AND ADOLESCENTS.
 

Author(s): Mahdi Shahriari, Naser Honar, Ali Yousefi, Hazhir Javaherizadeh

Journal: Arq Gastroenterol. ;55(1):78-81.

 

Celiac disease is an enteropathy caused by dietary gluten. The combination of serologic, genetic and histologic data has led to description of other categories of this disease.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Celiac disease" returned 176 free, full-text review articles on human participants. First 3 results:

Diagnostic challenges of celiac disease in a young child: A case report and a review of the literature.
 

Author(s): Cristina Oana Mărginean, Lorena Elena Meliţ, Vlăduţ Stefănuţ Săsăran, Cristian Dan Mărginean, Maria Oana Mărginean

Journal: Medicine (Baltimore). 2018 Jun;97(22):e10893.

 

Celiac disease is a chronic, immune-mediated, multiorgan disorder that affects susceptible individuals, and it is triggered by gluten and other prolamins.

Last Updated: 31 Dec 1969

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REVIEW OF CELIAC DISEASE PRESENTATION IN A PEDIATRIC TERTIARY CENTRE.
 

Author(s): Gracinda Nogueira Oliveira, Rajiv Mohan, Andrew Fagbemi

Journal: Arq Gastroenterol. ;55(1):86-93.

 

Celiac disease is an immune-mediated disorder with a multiform presentation and therefore a challenging diagnosis.

Last Updated: 31 Dec 1969

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Indications and Use of the Gluten Contamination Elimination Diet for Patients with Non-Responsive Celiac Disease.
 

Author(s): Maureen M Leonard, Pamela Cureton, Alessio Fasano

Journal:

 

For the majority of patients diagnosed with celiac disease, once a gluten-free diet is initiated, symptoms improve within weeks and may completely resolve in months. However, up to 30% of patients may show signs, symptoms or persistent small intestinal damage after one year on a gluten-free ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evidence-based Screening Strategies for Celiac Disease
 

Status: Recruiting

Condition Summary: Celiac Disease

 

Last Updated: 29 Nov 2017

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Prevention of Celiac Disease in Skåne
 

Status: Not yet recruiting

Condition Summary: Celiac Disease in Children

 

Last Updated: 7 Jun 2018

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Latiglutenase as a Treatment for Celiac Disease
 

Status: Not yet recruiting

Condition Summary: Celiac Disease

 

Last Updated: 13 Jul 2018

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