Central Pontine Myelinolysis

Common Name(s)

Central Pontine Myelinolysis

Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs when sodium deficiency is treated too rapidly.  The part of the brain called the pons is especially sensitive and too much sodium can damage nerve fibers.  Initial signs and symptoms appear within two to three days and include a depressed level of awareness, difficulty speaking, and difficulty swallowing.  Additional symptoms often occur in the next one to two weeks, including impaired thinking, weakness or paralysis in the arms and legs, stiffness, impaired sensation, and difficulty with coordination.  Severe CPM can lead to coma, Òlocked-inÓ syndrome, and death.  Treatment is focused on safely restoring sodium levels and relieving symptoms. Many affected people improve over weeks to months; however, some have permanent disability or develop new symptoms later on including behavioral or intellectual impairment or movement disorders like parkinsonism or tremor.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Central Pontine Myelinolysis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central Pontine Myelinolysis" returned 88 free, full-text research articles on human participants. First 3 results:

IMAGES IN CLINICAL MEDICINE. Central Pontine Myelinolysis.
 

Author(s): Aniket N Tavare, Diane Murray

Journal: N. Engl. J. Med.. 2016 Feb;374(7):e8.

 

Last Updated: 18 Feb 2016

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Diffuse large B-cell lymphoma presenting with central pontine myelinolysis: a case report.
 

Author(s): Eri Kawata, Reiko Isa, Junko Yamaguchi, Kazuna Tanba, Yasuhiko Tsutsumi, Yoshinari Nagakane, Hitoji Uchiyama, Teruaki Akaogi, Yutaka Kobayashi, Nobuhiko Uoshima

Journal:

 

The most common cause of central pontine myelinolysis is an overly rapid correction of hyponatremia, although it can also occur in patients with any condition leading to nutritional or electrolyte stress. We report a case of diffuse large B-cell lymphoma with central pontine myelinolysis ...

Last Updated: 17 Jun 2015

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Central pontine myelinolysis: a rare presentation secondary to hyperglycaemia.
 

Author(s): Monica Saini, Marlie Jane Mamauag, Rajinder Singh

Journal: Singapore Med J. 2015 Apr;56(4):e71-3.

 

Central pontine myelinolysis (CPM) is classically described as a demyelinating condition that results from the rapid correction of hyponatraemia. CPM has also been reported to arise from hyperglycaemia in association with concomitant acidosis, hypernatraemia and hyperosmolar syndrome. ...

Last Updated: 28 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central Pontine Myelinolysis" returned 3 free, full-text review articles on human participants. First 3 results:

Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes.
 

Author(s): R J Martin

Journal: J. Neurol. Neurosurg. Psychiatr.. 2004 Sep;75 Suppl 3():iii22-8.

 

Last Updated: 18 Aug 2004

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Idiopathic central pontine myelinolysis in childhood.
 

Author(s): J O Menakaya, E Wassmer, K Bradshaw, S Seri, W P Whitehouse

Journal: Dev Med Child Neurol. 2001 Oct;43(10):697-700.

 

Central pontine myelinolysis (CPM) is rare in childhood with only a few cases reported in world literature. We report a 7-year-old male who presented with acute ataxia, swallowing difficulties, dysarthria, and radiological features consistent with the disorder. He improved remarkably ...

Last Updated: 22 Oct 2001

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Parkinsonism and dystonia in central pontine and extrapontine myelinolysis.
 

Author(s): A Seiser, S Schwarz, M M Aichinger-Steiner, G Funk, P Schnider, M Brainin

Journal: J. Neurol. Neurosurg. Psychiatr.. 1998 Jul;65(1):119-21.

 

Parkinsonism as well as dystonic signs are rarely seen in central pontine myelinolysis and extrapontine myelinolysis. A 51 year old woman developed central pontine myelinolysis and extrapontine myelinolysis with parkinsonism after severe vomiting which followed alcohol and drug intake, ...

Last Updated: 23 Jul 1998

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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