Central precocious puberty

Common Name(s)

Central precocious puberty

Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by {1:Abreu et al., 2013}). Genetic Heterogeneity of Central Precocious Puberty Central precocious puberty-2 (CPPB2; {615346}) is caused by mutation in the MKRN3 gene ({603856}) on chromosome 15q11.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Central precocious puberty" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central precocious puberty" returned 86 free, full-text research articles on human participants. First 3 results:

The prevalence of brain abnormalities in boys with central precocious puberty may be overestimated.
 

Author(s): Jong Seo Yoon, Cheol Hwan So, Hae Sang Lee, Jung Sub Lim, Jin Soon Hwang

Journal:

 

Brain magnetic resonance imaging (MRI) is routinely performed to identify brain lesions in boys with central precocious puberty (CPP). We investigated the prevalence of CPP in Korean boys and the necessity for routine brain MRI examinations. This retrospective cross-sectional study ...

Last Updated: 31 Dec 1969

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Herbal medicine for idiopathic central precocious puberty: A protocol for a systematic review of controlled trials.
 

Author(s): Hye Lim Lee, Yoo Been Lee, Jun-Yong Choi, Ju Ah Lee

Journal: Medicine (Baltimore). 2018 Mar;97(13):e0267.

 

Herbal medicine is widely used in East Asia to treat idiopathic central precocious puberty (ICPP). Most of the available clinical trials that investigated herbal medicine for ICPP have been included in this review. This systematic review will assess the efficacy and safety of herbal ...

Last Updated: 31 Dec 1969

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[An analysis of cardiac autonomic nerve function in girls with idiopathic central precocious puberty].
 

Author(s): Lan-Fen Yi, Hong-Xia Wen, Mei Qiu, Xiao-Xiao Cao

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2017 Dec;19(12):1239-1242.

 

To investigate the cardiac autonomic nerve function in girls with idiopathic central precocious puberty (ICPP).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central precocious puberty" returned 6 free, full-text review articles on human participants. First 3 results:

A Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty.
 

Author(s): Abdullah Bereket

Journal: J Clin Res Pediatr Endocrinol. 2017 Dec;9(Suppl 2):33-48.

 

Central precocious puberty (CPP) is a diagnosis that pediatric endocrinologists worldwide increasingly make in girls of age 6-8 years and is mostly idiopathic. Part of the reason for increasing referral and diagnosis is the perception among the doctors as well as the patients that ...

Last Updated: 31 Dec 1969

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Central precocious puberty: revisiting the diagnosis and therapeutic management.
 

Author(s): Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior

Journal: Arch Endocrinol Metab. 2016 Apr;60(2):163-72.

 

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability ...

Last Updated: 31 Dec 1969

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MANAGEMENT OF ENDOCRINE DISEASE: Long-term outcomes of the treatment of central precocious puberty.
 

Author(s): Federica Guaraldi, Guglielmo Beccuti, Davide Gori, Lucia Ghizzoni

Journal: Eur. J. Endocrinol.. 2016 Mar;174(3):R79-87.

 

GnRH analogues (GnRHa) are the treatment of choice for central precocious puberty (CPP), with the main objective to recover the height potential compromised by the premature fusion of growth cartilages. The aim of this review was to analyze long-term effects of GnRHa on height, body ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 17 Oct 2017

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Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate
 

Status: Recruiting

Condition Summary: Precocious Puberty, Central

 

Last Updated: 22 Nov 2016

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Last Updated: 26 Feb 2018

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