Central precocious puberty

Common Name(s)

Central precocious puberty

Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by {1:Abreu et al., 2013}). Genetic Heterogeneity of Central Precocious Puberty Central precocious puberty-2 (CPPB2; {615346}) is caused by mutation in the MKRN3 gene ({603856}) on chromosome 15q11.
 

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Condition Specific Organizations

Following organizations serve the condition "Central precocious puberty" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central precocious puberty" returned 84 free, full-text research articles on human participants. First 3 results:

Serum Osteocalcin Levels in Girls with Central Precocious Puberty: Relation to the Onset of Puberty.
 

Author(s): Won Young Lee, Geehae Jung, Hye Ryun Kim, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee

Journal: Tohoku J. Exp. Med.. 2018 08;245(4):239-243.

 

Osteocalcin is the non-collagenous protein produced by osteoblasts in bone. When it is released into systemic circulation in its uncarboxylated form, it regulates fat and glucose metabolism. Recent studies have shown that osteocalcin is also involved in male fertility. Because the ...

Last Updated: 31 Dec 1969

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Applicability of a novel mathematical model for the prediction of adult height and age at menarche in girls with idiopathic central precocious puberty.
 

Author(s): Mateus Cavarzan Lopes, Carolina Oliveira Ramos, Ana Claudia Latronico, Berenice B Mendonça, Vinicius N Brito

Journal:

 

Unfavorable predicted adult height and psychosocial inadequacy represent parameters used to guide therapeutic intervention in girls with central precocious puberty. Gonadotropin-releasing hormone analog is the first-line treatment. The aim of this study was to compare two methods ...

Last Updated: 31 Dec 1969

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Subnormal Growth Velocity and Related Factors During GnRH Analog Therapy for Idiopathic Central Precocious Puberty
 

Author(s): Nursel Muratoğlu Şahin, Asiye Uğraş Dikmen, Semra Çetinkaya, Zehra Aycan

Journal: J Clin Res Pediatr Endocrinol. 2018 07;10(3):239-246.

 

Data concerning subnormal growth velocity (GV) and factors that influence this during gonadotropin-releasing hormone analog (GnRHa) therapy for idiopathic central precocious puberty (ICPP) are scarce. We investigated the incidence of subnormal GV and associated factors in patients ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central precocious puberty" returned 5 free, full-text review articles on human participants. First 3 results:

A Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty.
 

Author(s): Abdullah Bereket

Journal: J Clin Res Pediatr Endocrinol. 2017 Dec;9(Suppl 2):33-48.

 

Central precocious puberty (CPP) is a diagnosis that pediatric endocrinologists worldwide increasingly make in girls of age 6-8 years and is mostly idiopathic. Part of the reason for increasing referral and diagnosis is the perception among the doctors as well as the patients that ...

Last Updated: 31 Dec 1969

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Central precocious puberty: revisiting the diagnosis and therapeutic management.
 

Author(s): Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior

Journal: Arch Endocrinol Metab. 2016 Apr;60(2):163-72.

 

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability ...

Last Updated: 31 Dec 1969

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New causes of central precocious puberty: the role of genetic factors.
 

Author(s): Delanie Bulcao Macedo, Vinicius Nahime Brito, Ana Claudia Latronico

Journal: Neuroendocrinology. 2014 ;100(1):1-8.

 

A pivotal event in the onset of puberty in humans is the reemergence of the pulsatile release of the gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Pathways governing GnRH ontogeny and physiology have been discovered by studying animal models and humans with reproductive ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 17 Oct 2017

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Last Updated: 26 Feb 2018

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