Cerebral Poliodystrophy

Common Name(s)

Cerebral Poliodystrophy

Cerebral Poliodystrophy, also known as Alpers’ Disease and Christensen-Krabbe disease, is a genetic condition and affects infants and young children. Spastic limbs, seizures, blindness, and deafness characterize this condition during the first year of life, along with degeneration of the cerebral cortex (the part of the brain that controls memory, attention, language, and consciousness). This condition is autosomal recessive which means an individual must have two copies of the changed gene that causes the condition. A person with one changed gene would be a carrier of the condition but will not have any symptoms. If both parents are carriers, their children have a one in four chance of having the disease. Treatment varies on a case-by-case basis, and depends on the specific defects present. For example, doctors can seek help from various therapists and community services to provide support and care for families affected by intellectual disability due to degeneration of the cerebral cortex.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebral Poliodystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebral Poliodystrophy" returned 1 free, full-text research articles on human participants. First 3 results:

Progressive cerebral poliodystrophy--Alpers' disease. Disorganized giant neuronal mitochondria on electron microscopy.
 

Author(s): U Sandbank, P Lerman

Journal: J. Neurol. Neurosurg. Psychiatr.. 1972 Dec;35(6):749-55.

 

Three siblings who suffered from progressive mental retardation, seizures, and rigidity showed degeneration of the cerebral cortex. This was manifested by severe to complete neuronal loss with astrogliosis and microgliosis. In one child a brain biopsy was performed at the age of 3 ...

Last Updated: 15 Mar 1973

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebral Poliodystrophy" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpers Huttenlocher Natural History Study
 

Status: Recruiting

Condition Summary: Alpers Huttenlocher Syndrome

 

Last Updated: 25 Jan 2017

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