Chandler's Syndrome

Common Name(s)

Chandler's Syndrome

Chandler's syndrome is a rare eye disorder in which the single layer of cells lining the interior of the cornea proliferates, causing changes within the iris, corneal swelling, and unusually high pressure in the eye (glaucoma). This condition is one of three syndromes, along with progressive iris atrophy and Cogan-Reese syndrome, that make up the iridocorneal endothelial (ICE) syndrome. In most cases, only one eye is affected.  Symptoms may include reduced vision and pain.  Chandler's syndrome more often affects females and usually presents sometime during middle age. The cause of this disease is unknown.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chandler's Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chandler's Syndrome" returned 2 free, full-text research articles on human participants. First 3 results:

A case of Chandler's syndrome revealed by ultrastructural studies of the trabecular meshwork.
 

Author(s): Maiko Awai, Ryusuke Futa, Teruhiko Hamanaka, Akira Hirata, Takahisa Koga, Akira Kimura, Tomoko Miyagawa, Hidenobu Tanihara

Journal: Acta Ophthalmol Scand. 2005 Feb;83(1):113-4.

 

To investigate ultrastructural changes in the aqueous outflow route and discuss the mechanisms associated with intraocular pressure (IOP) elevation in a patient with presumably early stage Chandler's syndrome.

Last Updated: 31 Dec 1969

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Radiation-induced Chandler's syndrome.
 

Author(s): O Geyer, M Neufelder, A Michaeli-Cohen, M Lazar, S Sadetzki, B Modan

Journal: Isr. Med. Assoc. J.. 2000 Mar;2(3):241-2.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chandler's Syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

Clinicopathologic features of Chandler's syndrome.
 

Author(s): A Patel, K R Kenyon, L W Hirst, H A Quigley, W J Stark, R F Meyer, W R Green

Journal: Surv Ophthalmol. ;27(5):327-44.

 

The clinicopathologic features of Chandler's syndrome are elucidated based on a study of nine patients. Keratoplasty, trabeculectomy and/or iris specimens were studied by light, electron and, in six cases, specular microscopy. The prominent pathologic features were abnormalities of ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 28 Dec 2017

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Study of Endothelial Keratoplasty Outcomes
 

Status: Recruiting

Condition Summary: Fuchs' Endothelial Corneal Dystrophy; Bullous Keratopathy; Iridocorneal Endothelial Syndrome; Posterior Polymorphous Dystrophy

 

Last Updated: 24 Jan 2018

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