Childhood systemic lupus erythematosus

Common Name(s)

Childhood systemic lupus erythematosus, Childhood SLE

Childhood systemic lupus erythematosus (Childhood SLE) is an autoimmune condition that results in the swelling of skin, lungs, kidneys, nervous system, or other organs. An autoimmune disease is a condition in which the body’s immune system attacks its own tissues, mistaking it for unwanted invaders. Common symptoms of this condition include fever, fatigue, weight loss, hair loss, rashes on the face or upper body, sores on the mouth or nose, bruising, painful joints, seizures, and symptoms of anxiety or depression. There are periods when childhood SLE is very active (lots of symptoms), called flare, and periods when it is not (few if any symptoms), called remission.

Lupus is more common in females from African-American, Hispanic, South/Southeast Asian, or Native American ethnicities. At the younger ages however, it is more common than later ages for boys to be diagnosed with SLE. About 20% of cases of SLE are diagnosed in individuals under 20 years old. Few however are diagnosed under 5.

The exact cause of this condition is unknown. Genetic errors or environmental factors such as drug reactions, sun exposure, hormones during puberty may trigger childhood SLE. This condition is diagnosed if at least four physical symptoms are present. A detailed medical history, a physical examination, and blood tests may also be used to diagnose this condition. Although there is no cure for SLE, there are treatment options available to help manage the condition. There are medications available to help control swelling of the organs. Counseling may also be recommended. Talk with your child’s pediatrician and pediatric rheumatologist about the most current treatment options. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Childhood systemic lupus erythematosus" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Childhood systemic lupus erythematosus" returned 73 free, full-text research articles on human participants. First 3 results:

Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study.
 

Author(s): A Cavalcanti, R Santos, Z Mesquita, A L B P Duarte, N Lucena-Silva

Journal:

 

Childhood-onset systemic lupus erythematosus (cSLE) exhibits an aggressive clinical phenotype and severe complications. This could be due to a pro-inflammatory cytokine milieu. Therefore, we determined plasma levels of Th1 (IL-2, IFN-γ, TNF), Th2 (IL-4), Th17 (IL-17A, IL-6), and ...

Last Updated: 31 Dec 1969

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What are the benefits of two-dimensional speckle tracking echocardiography for diagnosis and treatment follow-up of childhood-onset systemic lupus erythematosus myocarditis?
 

Author(s): Gabriela Nunes Leal, Maria de Fátima Diniz, Juliana Brunelli, Alessandro C Lianza, Adriana M E Sallum, Clovis A Silva

Journal: Rev Assoc Med Bras (1992). 2016 Sep;62(6):490-493.

 

Last Updated: 31 Dec 1969

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Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study.
 

Author(s): Roberta C Gomes, Marco F Silva, Katia Kozu, Eloisa Bonfá, Rosa M Pereira, Maria T Terreri, Claudia S Magalhães, Silvana B Sacchetti, Roberto Marini, Melissa Fraga, Luciana M Carvalho, Cássia M Barbosa, Magda Carneiro-Sampaio, Clovis A Silva

Journal: Arthritis Care Res (Hoboken). 2016 Nov;68(11):1736-1741.

 

To evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (≥6 to <12 years); and group C, adolescent (≥12 to <18 years).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Childhood systemic lupus erythematosus" returned 7 free, full-text review articles on human participants. First 3 results:

Differences in clinical features observed between childhood-onset versus adult-onset systemic lupus erythematosus: A systematic review and meta-analysis.
 

Author(s): Pravesh Kumar Bundhun, Alka Kumari, Feng Huang

Journal: Medicine (Baltimore). 2017 Sep;96(37):e8086.

 

Systemic lupus erythematosus (SLE) affects people in childhood (childhood onset) or in adulthood (adult onset). Observational studies that have previously compared childhood-onset versus adult-onset SLE were often restricted to 1 ethnic group, or to a particular area, with a small ...

Last Updated: 31 Dec 1969

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Biomarkers for childhood-onset systemic lupus erythematosus.
 

Author(s): Khalid M Abulaban, Hermine I Brunner

Journal: Curr Rheumatol Rep. 2015 Jan;17(1):471.

 

Childhood-onset systemic lupus erythematosus (cSLE) is a systemic autoimmune disease characterized by the presence of autoantibodies. cSLE often affects multiple organs in the body and is known to have a poorer prognosis than adult-onset disease (Azevedo et al. 2014). Current laboratory ...

Last Updated: 31 Dec 1969

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Update on differences between childhood-onset and adult-onset systemic lupus erythematosus.
 

Author(s): Rina Mina, Hermine I Brunner

Journal:

 

Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.