Childhood systemic lupus erythematosus

Common Name(s)

Childhood systemic lupus erythematosus, Childhood SLE

Childhood systemic lupus erythematosus (Childhood SLE) is an autoimmune condition that results in the swelling of skin, lungs, kidneys, nervous system, or other organs. An autoimmune disease is a condition in which the body’s immune system attacks its own tissues, mistaking it for unwanted invaders. Common symptoms of this condition include fever, fatigue, weight loss, hair loss, rashes on the face or upper body, sores on the mouth or nose, bruising, painful joints, seizures, and symptoms of anxiety or depression. There are periods when childhood SLE is very active (lots of symptoms), called flare, and periods when it is not (few if any symptoms), called remission.

Lupus is more common in females from African-American, Hispanic, South/Southeast Asian, or Native American ethnicities. At the younger ages however, it is more common than later ages for boys to be diagnosed with SLE. About 20% of cases of SLE are diagnosed in individuals under 20 years old. Few however are diagnosed under 5.

The exact cause of this condition is unknown. Genetic errors or environmental factors such as drug reactions, sun exposure, hormones during puberty may trigger childhood SLE. This condition is diagnosed if at least four physical symptoms are present. A detailed medical history, a physical examination, and blood tests may also be used to diagnose this condition. Although there is no cure for SLE, there are treatment options available to help manage the condition. There are medications available to help control swelling of the organs. Counseling may also be recommended. Talk with your child’s pediatrician and pediatric rheumatologist about the most current treatment options. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Childhood systemic lupus erythematosus" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Childhood systemic lupus erythematosus" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Childhood systemic lupus erythematosus" returned 77 free, full-text research articles on human participants. First 3 results:

Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis.
 

Author(s): Merav Heshin-Bekenstein, Liat Perl, Aimee O Hersh, Emily von Scheven, Ed Yelin, Laura Trupin, Jinoos Yazdany, Erica F Lawson

Journal:

 

To compare final height to mid-parental target height among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and to evaluate the impact of age at SLE onset on final height.

Last Updated: 31 Dec 1969

Go To URL
Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
 

Author(s): Roberta Garcia Salomão, Luciana Martins de Carvalho, Clarice Izumi, Érika Silva Czernisz, José César Rosa, Sonir Roberto Rauber Antonini, Ana Carolina Bueno, Maria Olímpia Ribeiro do Vale Almada, Carolina de Almeida Coelho-Landell, Alceu Afonso Jordão, Virgínia Paes Leme Ferriani, Jacqueline Pontes Monteiro

Journal:

 

Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein.

Last Updated: 31 Dec 1969

Go To URL
Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX: Clinical Features and Survival of Childhood-Onset Systemic Lupus Erythematosus in China.
 

Author(s): Chan-Yuan Wu, Cai-Feng Li, Qing-Jun Wu, Jian-Hua Xu, Lin-Di Jiang, Lu Gong, Feng-Qi Wu, Jie-Ruo Gu, Jiu-Liang Zhao, Meng-Tao Li, Yan Zhao, Xiao-Feng Zeng,

Journal: Chin. Med. J.. 2017 Jun;130(11):1276-1282.

 

Approximately 15-20% cases of systemic lupus erythematosus (SLE) are diagnosed in children. There have been a few studies reporting the epidemiological data of pediatric-onset SLE (cSLE) in China, neither comparing the differences between cSLE and adult-onset SLE (aSLE). The aim of ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Childhood systemic lupus erythematosus" returned 8 free, full-text review articles on human participants. First 3 results:

[Research advances in the role of neutrophil extracellular traps in childhood-onset systemic lupus erythematosus].
 

Author(s): Lu Li, Hai-Dong Fu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2018 Mar;20(3):251-254.

 

Neutrophil extracellular traps (NETs) represent a form of cell death distinct from apoptosis or necrosis. The imbalance between the formation and degradation of NETs has long been considered to be closely associated with the activity of autoimmune diseases such as systemic lupus erythematous ...

Last Updated: 31 Dec 1969

Go To URL
Differences in clinical features observed between childhood-onset versus adult-onset systemic lupus erythematosus: A systematic review and meta-analysis.
 

Author(s): Pravesh Kumar Bundhun, Alka Kumari, Feng Huang

Journal: Medicine (Baltimore). 2017 Sep;96(37):e8086.

 

Systemic lupus erythematosus (SLE) affects people in childhood (childhood onset) or in adulthood (adult onset). Observational studies that have previously compared childhood-onset versus adult-onset SLE were often restricted to 1 ethnic group, or to a particular area, with a small ...

Last Updated: 31 Dec 1969

Go To URL
Biomarkers for childhood-onset systemic lupus erythematosus.
 

Author(s): Khalid M Abulaban, Hermine I Brunner

Journal: Curr Rheumatol Rep. 2015 Jan;17(1):471.

 

Childhood-onset systemic lupus erythematosus (cSLE) is a systemic autoimmune disease characterized by the presence of autoantibodies. cSLE often affects multiple organs in the body and is known to have a poorer prognosis than adult-onset disease (Azevedo et al. 2014). Current laboratory ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.